[Can medical treatment be the first-line treatment for most ectopic pregnancies? A series of 202 patients]
Fiche publication
Date publication
février 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MEYER Nicolas
Tous les auteurs :
Garbin O, Helmlinger C, Meyer N, David-Montefiore E, Vayssiere C
Lien Pubmed
Résumé
OBJECTIVES: To assess the efficacy and safety of a liberal policy of medical treatment for ectopic pregnancies (EUP). MATERIAL AND METHODS: Retrospective study of EUP that received active management between January 1999 and December 2003. Patients with rupture or near-rupture and those who refused medical treatment received surgical treatment. Other patients were treated by methotrexate. RESULTS: Two hundred and two EUP were managed; 26 % were treated surgically, 74 % medically. The success rate of medical treatment was 83 %. A ss-hCG threshold of 2526 IU/l was selected. Under this level, the success rate was 90.7 % compared with 68 % when it was higher (p=0.001). Cardiac activity tripled the failure rate. Morbidity with medical treatment consisted of an augmentation in transaminases in 18.8 % and one case of severe dermatosis (0.7 %). Almost half of the patients treated medically required hospitalizations. CONCLUSION: The extension of medical treatment in our population to 74 % of all EUP yielded a high success rate, 83 %.
Référence
J Gynecol Obstet Biol Reprod (Paris). 2010 Feb;39(1):30-6