Dr ZOLL Joffrey

Fiche personne

Coordonnées

Centre de recherche en biomédecine de Strasbourg CRBS
1 rue Eugène Boeckel - CS 60026
67084 STRASBOURG Cedex

03 68 85 38 67

Territoire

Alsace

Statut

Hospitalo-Universitaire

Affiliation

Université de Strasbourg (Unistra)

Centre de recherche en biomédecine de Strasbourg (CRBS)

Équipes/plateformes

Mitochondrie, stress oxydant et protection musculaire - UR 3072

Recherche

Mots clés : Physiologie, Performance, Santé, Exercice – Muscle squelettique, Athletes, Patients, fonction mitochondriale, exercice, entraînement – Entraînement, hypoxie, nutrition

Publications

Androgen receptor imprints satellite cell stemness and preserves their reservoir for lifelong regeneration and optimal repair.

Rizk JG, Ghaibour KC, Souali-Crespo S, Calvano E, Bilger A, Jacobs H, Messaddeq N, Cai Q, Grangirard E, Sahu R, Ferry A, Fourcade V, Zoll J, Zanardelli G, Molina N, Fontaine C, Arnal JF, Metzger D, Duteil D

Sci Adv. 2026 09 11;12(37):eaec8073

High-fat, low-carb diet reduces tumor growth and induces liver metabolism remodeling in a breast cancer mouse model.

Charlot A, Bringolf A, Mallard J, Jaulin A, Crouchet E, Duteil D, Alpy F, Tomasetto CL, Baumert T, Zoll J

Am J Physiol Cell Physiol. 2026 06 16;:

Targeting peroxiredoxin 2 prevents hepatocarcinogenesis in metabolic liver disease.

Crouchet E, Schaeffer E, Oudot MA, Moehlin J, Gadenne C, Jühling F, El Saghire H, Fujiwara N, Zhu S, Akter Rasha F, Durand SC, Charlot A, Ponsolles C, Martin R, Brignon N, Del Zompo F, Meiss Heydmann L, Parnot M, Hamdane N, Heide D, Hetzer J, Heikenwälder M, Felli E, Pessaux P, Pochet N, Zoll J, Cunniff B, Hoshida Y, Mailly L, Baumert TF, Schuster C

J Clin Invest. 2025 09 11;:

Mammary tumor development induces perturbation of liver glucose metabolism with inflammation and fibrosis.

Charlot A, Bringolf A, Mallard J, Jaulin A, Crouchet E, Charles AL, Duteil D, Alpy F, Tomasetto CL, Baumert TF, Zoll J

Am J Physiol Endocrinol Metab. 2025 03 19;:

Hypercaloric low-carbohydrate high-fat diet protects against the development of nonalcoholic fatty liver disease in obese mice in contrast to isocaloric Western diet.

Charlot A, Bringolf A, Mallard J, Charles AL, Niederhoffer N, Duteil D, Pagano AF, Geny B, Zoll J

Front Nutr. 2024 03 20;11:1366883

Changes in Macronutrients during Dieting Lead to Weight Cycling and Metabolic Complications in Mouse Model.

Charlot A, Bringolf A, Debrut L, Mallard J, Charles AL, Crouchet E, Duteil D, Geny B, Zoll J

Nutrients. 2024 02 25;16(5):

[Beneficial effects of ketogenic diet for Alzheimer's disease management].

Charlot A, Lernould A, Plus I, Zoll J

Biol Aujourdhui. 2023 11 29;217(3-4):253-263

Androgen receptor coordinates muscle metabolic and contractile functions.

Ghaibour K, Schuh M, Souali-Crespo S, Chambon C, Charlot A, Rizk J, Rovito D, Rerra AI, Cai Q, Messaddeq N, Zoll J, Duteil D, Metzger D

J Cachexia Sarcopenia Muscle. 2023 05 20;:

Octanoic Acid-Enrichment Diet Improves Endurance Capacity and Reprograms Mitochondrial Biogenesis in Skeletal Muscle of Mice.

Charlot A, Morel L, Bringolf A, Georg I, Charles AL, Goupilleau F, Geny B, Zoll J

Nutrients. 2022 06 29;14(13):

[Obesity, inflammation and COVID-19: preventive interest of ketogenic diet?].

Charlot A, Boumiza R, Roux M, Zoll J

Biol Aujourdhui. 2021 08 16;215(1-2):63-72

Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock.

Charlot A, Hutt F, Sabatier E, Zoll J

Nutrients. 2021 04 22;13(5):

[Ketogenic diet: a new nutritional strategy for cancer therapy?].

Charlot A, Conrad O, Zoll J

Biol Aujourdhui. 2020 12 24;214(3-4):115-123

La Société de Biologie de Strasbourg : 100 ans au service de la science et de la société

Antony P, Fournel S, Zoll J, Mantz JM, Befort K, Massotte D, Giégé P, Céraline J, Metzger D, Becker H, Drouard L, Florentz C, Martin R, Nébigil C, Potier S, Schaefer A, Schaeffer E, Schuster C, Bresson A, Quéméneur E, Choulier L, Matt N, Monassier L, Lugnier C, Freysz L, Hoffmann J, Dreyfus H, Romier C

Biol Aujourdhui. 2020 ;214(3-4):137-148

PGC-1β modulates statin-associated myotoxicity in mice.

Singh F, Zoll J, Duthaler U, Charles AL, Panajatovic MV, Laverny G, McWilliams TG, Metzger D, Geny B, Krähenbühl S, Bouitbir J

Arch. Toxicol.. 2018 Dec 3;:

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.

Diguet N, Trammell SAJ, Tannous C, Deloux R, Piquereau J, Mougenot N, Gouge A, Gressette M, Manoury B, Blanc J, Breton M, Decaux JF, Lavery GG, Baczkó I, Zoll J, Garnier A, Li Z, Brenner C, Mericskay M

Circulation. 2018 05 22;137(21):2256-2273

IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis.

Meyer A, Laverny G, Allenbach Y, Grelet E, Ueberschlag V, Echaniz-Laguna A, Lannes B, Alsaleh G, Charles AL, Singh F, Zoll J, Lonsdorfer E, Maurier F, Boyer O, Gottenberg JE, Nicot AS, Laporte J, Benveniste O, Metzger D, Sibilia J, Geny B

Acta Neuropathol.. 2017 Jun;:

[Skeletal muscle ischemia-reperfusion and ischemic conditioning pathophysiology-clinical applications for the vascular surgeon].

Delay C, Paradis S, Charles AL, Thaveau F, Chenesseau B, Zoll J, Chakfe N, Geny B, Lejay A

J Med Vasc. 2017 Feb;42(1):29-38

Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia.

Lejay A, Laverny G, Paradis S, Schlagowski AI, Charles AL, Singh F, Zoll J, Thaveau F, Lonsdorfer E, Dufour S, Favret F, Wolff V, Metzger D, Chakfe N, Geny B

Front Physiol. 2017 ;8:523

Muscles Susceptibility to Ischemia-Reperfusion Injuries Depends on Fiber Type Specific Antioxidant Level.

Charles AL, Guilbert AS, Guillot M, Talha S, Lejay A, Meyer A, Kindo M, Wolff V, Bouitbir J, Zoll J, Geny B

Front Physiol. 2017 ;8:52

Mitochondrial function following downhill and/or uphill exercise training in rats.

Schlagowski AI, Isner-Horobeti ME, Dufour SP, Rasseneur L, Enache I, Lonsdorfer-Wolf E, Doutreleau S, Charloux A, Goupilleau F, Bentz I, Charles AL, Kouassi BY, Zoll J, Geny B, Favret F

Muscle Nerve. 2016 11;54(5):925-935

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.

Stefely JA, Licitra F, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJP, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H, Pagliarini DJ

Mol Cell. 2016 08 18;63(4):608-620

Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion.

Paradis S, Charles AL, Meyer A, Lejay A, Scholey JW, Chakfé N, Zoll J, Geny B

Am J Physiol Cell Physiol. 2016 06 1;310(11):C968-82

Skeletal muscle ischemia-reperfusion injury and cyclosporine A in the aging rat.

Pottecher J, Kindo M, Chamaraux-Tran TN, Charles AL, Lejay A, Kemmel V, Vogel T, Chakfe N, Zoll J, Diemunsch P, Geny B

Fundam Clin Pharmacol. 2016 Jun;30(3):216-25

Endothelial function does not improve with high-intensity continuous exercise training in SHR: implications of eNOS uncoupling.

Battault S, Singh F, Gayrard S, Zoll J, Reboul C, Meyer G

Hypertens Res. 2016 02;39(2):70-8

Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle.

Bouitbir J, Singh F, Charles AL, Schlagowski AI, Bonifacio A, Echaniz-Laguna A, Geny B, Krähenbühl S, Zoll J

Antioxid Redox Signal. 2016 Jan 10;24(2):84-98

Left Ventricular Transmural Gradient in Mitochondrial Respiration Is Associated with Increased Sub-Endocardium Nitric Oxide and Reactive Oxygen Species Productions.

Kindo M, Gerelli S, Bouitbir J, Hoang Minh T, Charles AL, Mazzucotelli JP, Zoll J, Piquard F, Geny B

Front Physiol. 2016 ;7:331

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles.

Gali Ramamoorthy T, Laverny G, Schlagowski AI, Zoll J, Messaddeq N, Bornert JM, Panza S, Ferry A, Geny B, Metzger D

Nat Commun. 2015 Dec;6:10210

Angiotensin-converting enzyme inhibition prevents myocardial infarction-induced increase in renal cortical cGMP and cAMP phosphodiesterase activities.

Clauss F, Charloux A, Piquard F, Doutreleau S, Talha S, Zoll J, Lugnier C, Geny B

Fundam Clin Pharmacol. 2015 Aug;29(4):352-61

Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis.

Singh F, Charles AL, Schlagowski AI, Bouitbir J, Bonifacio A, Piquard F, Krähenbühl S, Geny B, Zoll J

Biochim Biophys Acta. 2015 Jul;1853(7):1574-85

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis.

Palamiuc L, Schlagowski A, Ngo ST, Vernay A, Dirrig-Grosch S, Henriques A, Boutillier AL, Zoll J, Echaniz-Laguna A, Loeffler JP, Rene F

EMBO Mol Med. 2015 Mar 27. pii: e201404433

A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathology.

Lejay A, Choquet P, Thaveau F, Singh F, Schlagowski A, Charles AL, Laverny G, Metzger D, Zoll J, Chakfe N, Geny B

Eur J Vasc Endovasc Surg. 2015 Feb;49(2):205-12

Apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection.

Zoll J, Bouitbir J, Sirvent P, Klein A, Charton A, Jimenez L, Péronnet FR, Geny B, Richard R

Drug Des Devel Ther. 2015 ;9:3589-97

Compartmentalization of Inflammatory Response Following Gut Ischemia Reperfusion.

Collange O, Charles AL, Lavaux T, Noll E, Bouitbir J, Zoll J, Chakfé N, Mertes M, Geny B

Eur J Vasc Endovasc Surg. 2015 Jan;49(1):60-5

Tetrahydrocannabinol induces brain mitochondrial respiratory chain dysfunction and increases oxidative stress: a potential mechanism involved in cannabis-related stroke.

Wolff V, Schlagowski AI, Rouyer O, Charles AL, Singh F, Auger C, Schini-Kerth V, Marescaux C, Raul JS, Zoll J, Geny B

Biomed Res Int. 2015 ;2015:323706

Effect of eccentric versus concentric exercise training on mitochondrial function.

Isner-Horobeti ME, Rasseneur L, Lonsdorfer-Wolf E, Dufour SP, Doutreleau S, Bouitbir J, Zoll J, Kapchinsky S, Geny B, Daussin FN, Burelle Y, Richard R

Muscle Nerve. 2014 Nov;50(5):803-11

Oxidative stress precedes skeletal muscle mitochondrial dysfunction during experimental aortic cross-clamping but is not associated with early lung, heart, brain, liver, or kidney mitochondrial impairment.

Guillot M, Charles AL, Chamaraux-Tran TN, Bouitbir J, Meyer A, Zoll J, Schneider F, Geny B

J. Vasc. Surg.. 2014 Oct;60(4):1043-51.e5

Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age.

Eschbach J, Sinniger J, Bouitbir J, Fergani A, Schlagowski AI, Zoll J, Geny B, Rene F, Larmet Y, Marion V, Baloh RH, Harms MB, Shy ME, Messadeq N, Weydt P, Loeffler JP, Ludolph AC, Dupuis L

Neurobiol Dis. 2013 Oct;58:220-30

Methylene blue protects liver oxidative capacity after gut ischaemia-reperfusion in the rat.

Collange O, Charles AL, Bouitbir J, Chenard MP, Zoll J, Diemunsch P, Thaveau F, Chakfe N, Piquard F, Geny B

Eur J Vasc Endovasc Surg. 2013 Feb;45(2):168-75

Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production.

Charles AL, Meyer A, Dal-Ros S, Auger C, Keller N, Ramamoorthy TG, Zoll J, Metzger D, Schini-Kerth V, Geny B

Exp Physiol. 2013 Feb;98(2):536-45

Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension.

Enache I, Charles AL, Bouitbir J, Favret F, Zoll J, Metzger D, Oswald-Mammosser M, Geny B, Charloux A

Mol Cell Biochem. 2013 Jan;373(1-2):161-70

Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase.

Dal-Ros S, Zoll J, Lang AL, Auger C, Keller N, Bronner C, Geny B, Schini-Kerth VB

Biochem Biophys Res Commun. 2011 Jan 14;404(2):743-9

Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues.

Eschbach J, Fergani A, Oudart H, Robin JP, Rene F, Gonzalez de Aguilar JL, Larmet Y, Zoll J, Hafezparast M, Schwalenstocker B, Loeffler JP, Ludolph AC, Dupuis L

Biochim Biophys Acta. 2011 Jan;1812(1):59-69