Dr LEFEBVRE Olivier

Fiche personne

Coordonnées

Tumor Biomechanics - Inserm U1109
Centre de Recherche en Biomédecine de Strasbourg
1 rue Eugène Boeckel
67084 STRASBOURG Cedex

03 88 27 53 68

Territoire

Alsace

Statut

Chercheur

Affiliation

Centre de recherche en biomédecine de Strasbourg (CRBS)

Équipes/plateformes

UMR 1109 - Equipe "Tumor Biomechanics"

Projets

Implication de la chaîne alpha1 de la laminine dans la tumorigenèse colique

2011 - Porteur du projet : Dr LEFEBVRE Olivier

Publications

Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells.

Gensbittel V, Yesilata Z, Bochler L, Follain G, Nemoz-Billet L, Lefebvre O, Uhlmann K, Larnicol A, Ammirati GEM, Harlepp S, Goswami R, Girardo S, Paulen L, Hyenne V, Mittelheisser V, Stemmelen T, Molitor A, Carapito R, Belthier G, Pannequin J, Kräter M, Müller DJ, Balzani D, Guck J, Osmani N, Goetz JG

Nat Mater. 2026 01 19;:

Serum albumin-coated stellate mesoporous silica nanocomposites inhibit metastatic outgrowth in zebrafish embryos.

Asokan N, Mittelheisser V, Jablonski A, Adam A, Bizeau J, Harlepp S, Hyenne V, Lefebvre O, Goetz JG, Tasso M, Mertz D

Nanoscale. 2025 11 27;:

Functionalization of lipid nanoemulsions with humanized antibodies using plug-and-play cholesterol anchor for targeting cancer cells.

Boide-Trujillo VJ, Mittelheisser V, Liu F, Lefebvre O, Andreiuk B, Anton N, Goetz JG, Klymchenko AS

Nanoscale Adv. 2025 09 23;:

Depletion of all platelet integrins impacts hemostasis, thrombosis, and tumor metastasis.

Janus-Bell E, Liboni C, Yakusheva A, Mittelheisser V, Mouriaux C, Bourdon C, Bochler L, Hyenne V, Garcia-Leon M, Lefebvre O, Goetz JG, Mangin PH

iScience. 2025 09 19;28(9):113250

Platelets: tailoring metastasis treatment.

Mittelheisser V, Liboni C, Trivigno SMG, Lefebvre O, Mangin PH, Goetz JG

Trends Cancer. 2025 07 17;:

Nanomaterials Trigger Functional Anti-Tumoral Responses in Primary Human Immune Cells.

Mittelheisser V, Lefebvre O, Banerjee M, Ghosh S, Dupas A, Diringer MC, Blumberger J, Bochler L, Harlepp S, Larnicol A, Pichot A, Stemmelen T, Molitor A, Moritz C, Carapito C, Carapito R, Charbonnière LJ, Lux F, Tillement O, Goetz JG, Detappe A

Adv Sci (Weinh). 2025 07 12;:e05729

Reinforced Polymer-Nanoparticle Hydrogels for Subcutaneous and Sustained Delivery of Trastuzumab.

Bovone G, Bernhard S, Jacquot G, Mittelheisser V, Mirjolet C, Guzzi EA, Paganella LG, Liebi L, Draussin J, Lopez Navarro P, Barbé E, Lefebvre O, Goetz JG, Charbonnière LJ, Pivot X, Harlepp S, Tibbitt MW, Detappe A

Adv Healthc Mater. 2025 06 9;:e2404660

Peripheral positioning of lysosomes supports melanoma aggressiveness.

Jerabkova-Roda K, Peralta M, Huang KJ, Mousson A, Bourgeat Maudru C, Bochler L, Busnelli I, Karali R, Justiniano H, Lisii LM, Carl P, Mittelheisser V, Asokan N, Larnicol A, Lefebvre O, Lachuer H, Pichot A, Stemmelen T, Molitor A, Scheid L, Frenger Q, Gros F, Hirschler A, Delalande F, Sick E, Carapito R, Carapito C, Lipsker D, Schauer K, Rondé P, Hyenne V, Goetz JG

Nat Commun. 2025 04 9;16(1):3375

Endothelial calcium firing mediates the extravasation of metastatic tumor cells.

Peralta M, Dupas A, Larnicol A, Lefebvre O, Goswami R, Stemmelen T, Molitor A, Carapito R, Girardo S, Osmani N, Goetz JG

iScience. 2025 02 21;28(2):111690

Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity.

Li C, Kaur A, Pavlidaki A, Spenlé C, Rajnpreht I, Donnadieu E, Salomé N, Molitor A, Carapito R, Wack F, Erne W, Lefebvre O, Averous G, Mitrentsi I, Loustau T, Orend G

Proc Natl Acad Sci U S A. 2024 10 15;121(42):e2404485121

Platelets favor the outgrowth of established metastases.

Garcia-Leon MJ, Liboni C, Mittelheisser V, Bochler L, Follain G, Mouriaux C, Busnelli I, Larnicol A, Colin F, Peralta M, Osmani N, Gensbittel V, Bourdon C, Samaniego R, Pichot A, Paul N, Molitor A, Carapito R, Jandrot-Perrus M, Lefebvre O, Mangin PH, Goetz JG

Nat Commun. 2024 05 13;15(1):3297

Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis.

Mary B, Asokan N, Jerabkova-Roda K, Larnicol A, Busnelli I, Stemmelen T, Pichot A, Molitor A, Carapito R, Lefebvre O, Goetz JG, Hyenne V

EMBO Rep. 2023 11 16;:e57042

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells.

Follain G, Osmani N, Gensbittel V, Asokan N, Larnicol A, Mercier L, Garcia-Leon MJ, Busnelli I, Pichot A, Paul N, Carapito R, Bahram S, Lefebvre O, Goetz JG

Sci Rep. 2021 Jun 23;11(1):13144

Fluorescent nanocarriers targeting VCAM-1 for early detection of senescent endothelial cells.

Belcastro E, Rehman AU, Remila L, Park SH, Gong DS, Anton N, Auger C, Lefebvre O, Goetz JG, Collot M, Klymchenko AS, Vandamme TF, Schini-Kerth VB

Nanomedicine. 2021 Mar 10;:102379

Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes.

Ghoroghi S, Mary B, Larnicol A, Asokan N, Klein A, Osmani N, Busnelli I, Delalande F, Paul N, Halary S, Gros F, Fouillen L, Haeberle AM, Royer C, Spiegelhalter C, André-Grégoire G, Mittelheisser V, Detappe A, Murphy K, Timpson P, Carapito R, Blot-Chabaud M, Gavard J, Carapito C, Vitale N, Lefebvre O, Goetz JG, Hyenne V

Elife. 2021 Jan 6;10:

[Influence of fluid mechanics on metastasis formation].

Follain G, Gensbittel V, Mary B, Lefebvre O, Harlepp S, Hyenne V, Goetz JG

Med Sci (Paris). 2020 Oct;36(10):872-878

Intrauterine Pressures Adjusted by Reichert's Membrane Are Crucial for Early Mouse Morphogenesis.

Ueda Y, Kimura-Yoshida C, Mochida K, Tsume M, Kameo Y, Adachi T, Lefebvre O, Hiramatsu R, Matsuo I

Cell Rep. 2020 May 19;31(7):107637

Prediction of Drug Efficacy in Colon Cancer Preclinical Models Using a Novel Ranking Method of Gene Expression.

Fritz J, Lefebvre O, Fernandez A, Schmidt J, Bagnard D

Cancers (Basel). 2020 Jan 8;12(1):

Metastatic Tumor Cells Exploit Their Adhesion Repertoire to Counteract Shear Forces during Intravascular Arrest.

Osmani N, Follain G, García León MJ, Lefebvre O, Busnelli I, Larnicol A, Harlepp S, Goetz JG

Cell Rep. 2019 Sep 3;28(10):2491-2500.e5

Tenascin-C increases lung metastasis by impacting blood vessel invasions.

Sun Z, Velázquez-Quesada I, Murdamoothoo D, Ahowesso C, Yilmaz A, Spenlé C, Averous G, Erne W, Oberndorfer F, Oszwald A, Kain R, Bourdon C, Mangin P, Deligne C, Midwood K, Abou-Faycal C, Lefebvre O, Klein A, van der Heyden M, Chenard MP, Christofori G, Mathelin C, Loustau T, Hussenet T, Orend G

Matrix Biol.. 2019 Jul 6;:

Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo.

Hyenne V, Ghoroghi S, Collot M, Bons J, Follain G, Harlepp S, Mary B, Bauer J, Mercier L, Busnelli I, Lefebvre O, Fekonja N, Garcia-Leon MJ, Machado P, Delalande F, López AA, Silva SG, Verweij FJ, van Niel G, Djouad F, Peinado H, Carapito C, Klymchenko AS, Goetz JG

Dev. Cell. 2019 Feb 4;:

Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma.

Mammadova-Bach E, Rupp T, Spenlé C, Jivkov I, Shankaranarayanan P, Klein A, Pisarsky L, Méchine-Neuville A, Cremel G, Kedinger M, De Wever O, Ambartsumian N, Robine S, Pencreach E, Guenot D, Simon-Assmann P, Goetz JG, Orend G, Lefebvre O

Biol. Cell. 2018 Jun 15;:

Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells.

Follain G, Osmani N, Azevedo AS, Allio G, Mercier L, Karreman MA, Solecki G, Garcia Leòn MJ, Lefebvre O, Fekonja N, Hille C, Chabannes V, Dollé G, Metivet T, Hovsepian F, Prudhomme C, Pichot A, Paul N, Carapito R, Bahram S, Ruthensteiner B, Kemmling A, Siemonsen S, Schneider T, Fiehler J, Glatzel M, Winkler F, Schwab Y, Pantel K, Harlepp S, Goetz JG

Dev. Cell. 2018 Apr 9;45(1):33-52.e12

Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal.

Rayagiri SS, Ranaldi D, Raven A, Mohamad Azhar NIF, Lefebvre O, Zammit PS, Borycki AG

Nat Commun. 2018 03 14;9(1):1075

Tenascin-C Promotes Tumor Cell Migration and Metastasis through Integrin α9β1-Mediated YAP Inhibition.

Sun Z, Schwenzer A, Rupp T, Murdamoothoo D, Vegliante R, Lefebvre O, Klein A, Hussenet T, Orend G

Cancer Res.. 2018 Feb 15;78(4):950-961

Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features.

Carapito R, Konantz M, Paillard C, Miao Z, Pichot A, Leduc MS, Yang Y, Bergstrom KL, Mahoney DH, Shardy DL, Alsaleh G, Naegely L, Kolmer A, Paul N, Hanauer A, Rolli V, Müller JS, Alghisi E, Sauteur L, Macquin C, Morlon A, Sancho CS, Amati-Bonneau P, Procaccio V, Mosca-Boidron AL, Marle N, Osmani N, Lefebvre O, Goetz JG, Unal S, Akarsu NA, Radosavljevic M, Chenard MP, Rialland F, Grain A, Béné MC, Eveillard M, Vincent M, Guy J, Faivre L, Thauvin-Robinet C, Thevenon J, Myers K, Fleming MD, Shimamura A, Bottollier-Lemallaz E, Westhof E, Lengerke C, Isidor B, Bahram S

J. Clin. Invest.. 2017 Oct;:

Going live with tumor exosomes and microvesicles.

Hyenne V, Lefebvre O, Goetz JG

Cell Adh Migr. 2017 Mar;11(2):173-186

Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack.

Lee KZ, Lestradet M, Socha C, Schirmeier S, Schmitz A, Spenlé C, Lefebvre O, Keime C, Yamba WM, Bou Aoun R, Liegeois S, Schwab Y, Simon-Assmann P, Dalle F, Ferrandon D

Cell Host Microbe. 2016 Dec;20(6):716-730

Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling.

Rupp T, Langlois B, Koczorowska MM, Radwanska A, Sun Z, Hussenet T, Lefebvre O, Murdamoothoo D, Arnold C, Klein A, Biniossek ML, Hyenne V, Naudin E, Velazquez-Quesada I, Schilling O, Van Obberghen-Schilling E, Orend G

Cell Rep. 2016 Dec;17(10):2607-2619

Hemidesmosome integrity protects the colon against colitis and colorectal cancer.

De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, Méchine-Neuville A, Siebert S, Pfister V, Lepage P, Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse E

Gut. 2016 Jul;:

RAL-1 controls multivesicular body biogenesis and exosome secretion.

Hyenne V, Apaydin A, Rodriguez D, Spiegelhalter C, Hoff-Yoessle S, Diem M, Tak S, Lefebvre O, Schwab Y, Goetz JG, Labouesse M

J. Cell Biol.. 2015 Oct;211(1):27-37

Identification of proteins associated with RNA polymerase III using a modified tandem chromatin affinity purification.

Nguyen NT, Saguez C, Conesa C, Lefebvre O, Acker J

Gene. 2015 Feb;556(1):51-60

The laminin response in inflammatory bowel disease: protection or malignancy?

Spenle C, Lefebvre O, Lacroute J, Mechine-Neuville A, Barreau F, Blottiere HM, Duclos B, Arnold C, Hussenet T, Hemmerle J, Gullberg D, Kedinger M, Sorokin L, Orend G, Simon-Assmann P

PLoS One. 2014 Oct 27;9(10):e111336

Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model.

Saupe F, Schwenzer A, Jia Y, Gasser I, Spenle C, Langlois B, Kammerer M, Lefebvre O, Hlushchuk R, Rupp T, Marko M, van der Heyden M, Cremel G, Arnold C, Klein A, Simon-Assmann P, Djonov V, Neuville-Mechine A, Esposito I, Slotta-Huspenina J, Janssen KP, de Wever O, Christofori G, Hussenet T, Orend G

Cell Rep. 2013 Oct 31;5(2):482-92

Integrin alpha6beta1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis.

Schaff M, Tang C, Maurer E, Bourdon C, Receveur N, Eckly A, Hechler B, Arnold C, de Arcangelis A, Nieswandt B, Denis CV, Lefebvre O, Georges-Labouesse E, Gachet C, Lanza F, Mangin PH

Circulation. 2013 Jul 30;128(5):541-52.

Laminins and retinal vascular development.

Edwards MM, Lefebvre O

Cell Adh Migr. 2013 Jan-Feb;7(1):82-9

Dysregulation of laminins in intestinal inflammation.

Spenle C, Hussenet T, Lacroute J, Lefebvre O, Kedinger M, Orend G, Simon-Assmann P

Pathol Biol (Paris). 2012 Feb;60(1):41-7

Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice.

Ritie L, Spenle C, Lacroute J, Bolcato-Bellemin AL, Lefebvre O, Bole-Feysot C, Jost B, Klein A, Arnold C, Kedinger M, Bagnard D, Orend G, Simon-Assmann P

PLoS One. 2012;7(5):e37710