Factors influencing inclusion in digestive cancer clinical trials: A population-based study.

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Date publication

mai 2015

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BEDENNE Laurent, Pr BINQUET Christine, Dr BOUVIER Anne-Marie, Dr FOURNEL Isabelle, Dr JOOSTE Valérie


Tous les auteurs :
Frerot M, Jooste V, Binquet C, Fournel I, Bedenne L, Bouvier AM

Résumé

BACKGROUND: Inclusion in a randomized therapeutic trial represents an optimal therapeutic strategy. AIMS: To determine the influence of demographic characteristics and deprivation on the enrolment of patients in digestive cancer clinical trials. METHODS: Between 2004 and 2010, 4632 patients were recorded by the Burgundy Digestive Cancer Registry. According to a balancing score, the 136 patients included in a clinical trial were matched with 272 patients who met the eligibility criteria for trials. Deprivation was measured by the ecological European deprivation index. A conditional multivariate logistic regression was performed. RESULTS: Patients aged over 75 years were significantly less likely to be included in clinical trials than younger patients (odds ratio 0.33; [0.13-0.87]). Patients treated in private institutions were also less likely to be enrolled than those treated in public institutions (odds ratio 0.04; [0.01-0.16]; p

Référence

Dig Liver Dis. 2015 May 28. pii: S1590-8658(15)00346-1