Chronic viral hepatitis and risk of lymphoid malignancies: a retrospective twelve-year population-based cohort study in Cote d'Or, France.

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Date publication

février 2012


Membres identifiés du Cancéropôle Est :
Pr BINQUET Christine, Pr HILLON Patrick, Dr JOOSTE Valérie, Pr MAYNADIE Marc, Dr MINELLO Anne, Pr QUANTIN Catherine

Tous les auteurs :
Proby C, Minello A, Quantin C, Jooste V, Binquet C, Hagi M, Mounier M, Benzenine E, Hillon P, Maynadie M


BACKGROUND: The association between hepatitis C infection and lymphoid malignancies is still a matter of debate. The hypothesis of a relationship between hepatitis B and lymphoid neoplasms is more recent and has been far less thoroughly explored. AIM: The aim of this study was to evaluate the association between hepatitis C and B infections and B cell non-Hodgkin and Hodgkin lymphomas. METHODS: We took advantage of the co-existence in the French administrative area of Cote d'Or of two specialized registries - one for viral hepatitis and one for haematological diseases - to conduct a population-based, cohort study covering a 12-year period. The databases were anonymized and then linked using a probabilistic model. RESULTS: There were 8234 person-years at risk in the hepatitis C cohort and 2784 in the hepatitis B cohort. We found 6 cases of non-Hodgkin lymphoma in the hepatitis C cohort, resulting in an overall adjusted standardized incidence ratio of 3.42 (CI: 1.25-7.45). Three of these 6 cases were diffuse-large-B-cell-lymphoma. Cirrhosis was associated with a higher risk of non-Hodgkin lymphoma in the hepatitis C cohort (relative risk=8.4, p


Dig Liver Dis. 2012 Feb;44(2):160-5