Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study.
Fiche publication
Date publication
mars 2023
Journal
British journal of anaesthesia
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLET Pierre, Pr GUEANT Jean-Louis
Tous les auteurs :
Mertes PM, Petitpain N, Tacquard C, Delpuech M, Baumann C, Malinovsky JM, Longrois D, Gouel-Cheron A, Le Quang D, Demoly P, Guéant JL, Gillet P,
Lien Pubmed
Résumé
Neuromuscular blocking agents (NMBAs) are among the leading cause of perioperative anaphylaxis, and most of these reactions are IgE mediated. Allergic sensitisation induced by environmental exposure to other quaternary ammonium-containing compounds, such as pholcodine, has been suggested. The aim of this study was to assess the relationship between pholcodine exposure and NMBA-related anaphylaxis.
Mots clés
anaesthesia, anaphylaxis, neuromuscular blocking agents, pholcodine, quaternary ammonium compounds
Référence
Br J Anaesth. 2023 03 24;: