Vitamin B Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.
Fiche publication
Date publication
juillet 2021
Journal
Molecular nutrition & food research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis, Dr DREUMONT Natacha
Tous les auteurs :
Mosca P, Robert A, Alberto JM, Meyer M, Kundu U, Hergalant S, Umoret R, Coelho D, Guéant JL, Leheup B, Dreumont N
Lien Pubmed
Résumé
Vitamin B deficiency presents various neurological manifestations, such as cognitive dysfunction, mental retardation, or memory impairment. However, the involved molecular mechanisms remain to date unclear. Vitamin B is essential for synthesizing S-adenosyl methionine (SAM), the methyl group donor used for almost all transmethylation reactions. Here, we investigated the m6A methylation of mRNAs and their related gene expression in models of vitamin B deficiency.
Mots clés
epitranscriptomics; m6A; methylation; nutrient; vitamin B12
Référence
Mol Nutr Food Res. 2021 Jul 22;:e2100206