Dr COELHO David

Fiche personne

Coordonnées

UMRS Inserm 1256 NGERE
9 avenue de la Forêt de Haye – BP 20199
54505 VANDOEUVRE-LES-NANCY Cedex

03 72 74 61 50

Territoire

Lorraine

Statut

Chercheur

Affiliation

Inserm U1256 "Nutrition, génétique et exposition aux risques environnementaux" (Inserm U1256 NGERE)

Équipes/plateformes

U1256 - Equipe "Métabolisme des monocarbones et épigénomique dans les origines développementales des maladies héréditaires et complexes"

Publications

Methionine Synthase Interacts With the Methionine Adenosyl-Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus.

Jeandel M, Alberto JM, Baspinar O, Robert A, Dreumont N, Alsahly Z, Meyre D, Guéant JL, Coelho D

J Inherit Metab Dis. 2026 07;49(4):e70211

High-Dose L-Serine Supplementation During Febrile Decompensation in Deficiency: A Case Report and Review of the Literature.

Valle VA, Wiedemnan A, Feigerlova E, Coelho D, Jeannesson E, Rotaru I, Merten M, Raharimanana A, Feillet F, Ravel JM

JIMD Rep. 2026 05;67:e70090

SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism.

Matmat K, Hassan Z, Pourié G, Atlasi Y, Seal SV, Jeandel M, Arnold C, Luharia S, Umoret R, Safar R, Heinken A, Alberto JM, Baspinar O, Paoli J, Hergalant S, Rouyer P, Camadro JM, Lignières L, Coelho D, Guéant JL, Guéant-Rodriguez RM

Cell Rep Med. 2026 02 25;:102643

Multiomic analysis in fibroblasts of patients with inborn errors of cobalmin metabolism reveals concordance with clinical and metabolic variability.

Wiedemann A, Oussalah A, Guéant Rodriguez RM, Jeannesson E, Mertens M, Rotaru I, Alberto JM, Baspinar O, Rashka C, Hassan Z, Siblini Y, Matmat K, Jeandel M, Chery C, Robert A, Chevreux G, Lignières L, Camadro JM, Feillet F, Coelho D, Guéant JL

EBioMedicine. 2024 01 1;99:104911

A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism.

Matmat K, Conart JB, Graindorge PH, El Kouche S, Hassan Z, Siblini Y, Umoret R, Safar R, Baspinar O, Robert A, Alberto JM, Oussalah A, Coelho D, Guéant JL, Guéant-Rodriguez RM

Clin Epigenetics. 2023 10 5;15(1):158

Cognitive Impairment Is Associated with AMPAR Glutamatergic Dysfunction in a Mouse Model of Neuronal Methionine Synthase Deficiency.

Hassan Z, Coelho D, Bossenmeyer-Pourié C, Matmat K, Arnold C, Savladori A, Alberto JM, Umoret R, Guéant JL, Pourié G

Cells. 2023 04 27;12(9):

Epimutation in inherited metabolic disorders: the influence of aberrant transcription in adjacent genes.

Guéant JL, Siblini Y, Chéry C, Schmitt G, Guéant-Rodriguez RM, Coelho D, Watkins D, Rosenblatt DS, Oussalah A

Hum Genet. 2022 Feb 21;:

Ocular manifestations in patients with inborn errors of intracellular cobalamin metabolism: a systematic review.

Matmat K, Guéant-Rodriguez RM, Oussalah A, Wiedemann-Fodé A, Dionisi-Vici C, Coelho D, Guéant JL, Conart JB

Hum Genet. 2021 Oct 15;:

Causes and consequences of impaired methionine synthase activity in acquired and inherited disorders of vitamin B metabolism.

Guéant JL, Guéant-Rodriguez RM, Kosgei VJ, Coelho D

Crit Rev Biochem Mol Biol. 2021 Oct 5;:1-23

A bi-allelic loss-of-function SARS1 variant in children with neurodevelopmental delay, deafness, cardiomyopathy, and decompensation during fever.

Ravel JM, Dreumont N, Mosca P, Smith DEC, Mendes MI, Wiedemann A, Coelho D, Schmitt E, Rivière JB, Mau-Them FT, Thevenon J, Kuentz P, Polivka M, Fuchs SA, Kok G, Thauvin-Robinet C, Guéant JL, Salomons GS, Faivre L, Feillet F

Hum Mutat. 2021 Sep 27;:

Vitamin B Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.

Mosca P, Robert A, Alberto JM, Meyer M, Kundu U, Hergalant S, Umoret R, Coelho D, Guéant JL, Leheup B, Dreumont N

Mol Nutr Food Res. 2021 Jul 22;:e2100206

Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism.

Kosgei VJ, Coelho D, Guéant-Rodriguez RM, Guéant JL

Cells. 2020 Aug 11;9(8):

Analysis of fibroblasts from patients with cblC and cblG genetic defects of cobalamin metabolism reveals global dysregulation of alternative splicing.

Rashka C, Hergalant S, Dreumont N, Oussalah A, Camadro JM, Marchand V, Hassan Z, Baumgartner MR, Rosenblatt DS, Feillet F, Guéant JL, Coelho D

Hum. Mol. Genet.. 2020 Feb 18;:

Brain Susceptibility to Methyl Donor Deficiency: From Fetal Programming to Aging Outcome in Rats.

Hassan Z, Coelho D, Kokten T, Alberto JM, Umoret R, Daval JL, Guéant JL, Bossenmeyer-Pourié C, Pourié G

Int J Mol Sci. 2019 Nov 14;20(22):

SIRT1 activation rescues the mislocalization of RNA-binding proteins and cognitive defects induced by inherited cobalamin disorders.

Ghemrawi R, Arnold C, Battaglia-Hsu SF, Pourié G, Trinh I, Bassila C, Charif R, Wiedemann A, Flayac J, Robert A, Dreumont N, Feillet F, Guéant JL, Coelho D

Metab. Clin. Exp.. 2019 Oct 28;:153992

Mutations in MTHFR and POLG impaired activity of the mitochondrial respiratory chain in 46-year-old twins with spastic paraparesis.

Wiedemann A, Chery C, Coelho D, Flayac J, Gueguen N, Desquiret-Dumas V, Feillet F, Lavigne C, Neau JP, Fowler B, Baumgartner MR, Reynier P, Guéant JL, Oussalah A

J. Hum. Genet.. 2019 Oct 23;:

Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR.

Battaglia-Hsu SF, Ghemrawi R, Coelho D, Dreumont N, Mosca P, Hergalant S, Gauchotte G, Sequeira JM, Ndiongue M, Houlgatte R, Alberto JM, Umoret R, Robert A, Paoli J, Jung M, Quadros EV, Guéant JL

Nucleic Acids Res.. 2018 Jul 17;:

APRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients.

Guéant JL, Chéry C, Oussalah A, Nadaf J, Coelho D, Josse T, Flayac J, Robert A, Koscinski I, Gastin I, Filhine-Tresarrieu P, Pupavac M, Brebner A, Watkins D, Pastinen T, Montpetit A, Hariri F, Tregouët D, Raby BA, Chung WK, Morange PE, Froese DS, Baumgartner MR, Benoist JF, Ficicioglu C, Marchand V, Motorin Y, Bonnemains C, Feillet F, Majewski J, Rosenblatt DS

Nat Commun. 2018 01 4;9(1):67

Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B-trafficking proteins ABCD4 and LMBD1.

Fettelschoss V, Burda P, Sagné C, Coelho D, De Laet C, Lutz S, Suormala T, Fowler B, Pietrancosta N, Gasnier B, Bornhauser B, Froese DS, Baumgartner MR

J Biol Chem. 2017 07 14;292(28):11980-11991

Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart.

Gueant JL, Elakoum R, Ziegler O, Coelho D, Feigerlova E, Daval JL, Gueant-Rodriguez RM

Pflugers Arch. 2014 May;466(5):833-50

Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia.

Fofou-Caillierez MB, Mrabet NT, Chery C, Dreumont N, Flayac J, Pupavac M, Paoli J, Alberto JM, Coelho D, Camadro JM, Feillet F, Watkins D, Fowler B, Rosenblatt DS, Gueant JL

Hum Mol Genet. 2013 Nov 15;22(22):4591-601

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