Implementation and use of whole exome sequencing in daily practice for metastatic solid cancer.
Fiche publication
Date publication
janvier 2020
Journal
EBioMedicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ARNOULD Laurent, Dr BERTAUT Aurélie, Dr BOIDOT Romain, Pr BORG Christophe, Dr FOUCHER Pascal, Pr GHIRINGHELLI François, Dr LADOIRE Sylvain, Pr LEPAGE Côme, Pr FAIVRE Laurence, Mme TRUNTZER Caroline, Dr VINCENT Julie, Dr HERVIEU Alice, Dr FAVIER Laure, Dr BENGRINE-LEFEVRE Leila, Dr NAMBOT Sophie, Dr DESMOULINS Isabelle, Dr FUMET Jean-David, Dr HENNEQUIN Audrey
Tous les auteurs :
Réda M, Richard C, Bertaut A, Niogret J, Collot T, Fumet JD, Blanc J, Truntzer C, Desmoulins I, Ladoire S, Hennequin A, Favier L, Bengrine L, Vincent J, Hervieu A, Dusserre JG, Lepage C, Foucher P, Borg C, Albuisson J, Arnould L, Nambot S, Faivre L, Boidot R, Ghiringhelli F
Lien Pubmed
Résumé
Genomically-guided clinical trials are performed across different tumor types sharing genetic mutations, but trial organization remains complex. Here we address the feasibility and utility of routine somatic and constitutional exome analysis in metastatic cancer patients.
Mots clés
Molecular profiling of cancer, exome sequencing analysis, metastatic cancer precision Medicine, routine care, somatic and constitutional analysis
Référence
EBioMedicine. 2020 Jan 7;51:102624