SIRT1 activation rescues the mislocalization of RNA-binding proteins and cognitive defects induced by inherited cobalamin disorders.
Fiche publication
Date publication
octobre 2019
Journal
Metabolism: clinical and experimental
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis, Dr BATTAGLIA-HSU Shyue-Fang, Dr DREUMONT Natacha
Tous les auteurs :
Ghemrawi R, Arnold C, Battaglia-Hsu SF, Pourié G, Trinh I, Bassila C, Charif R, Wiedemann A, Flayac J, Robert A, Dreumont N, Feillet F, Guéant JL, Coelho D
Lien Pubmed
Résumé
The molecular consequences of inborn errors of vitamin B12 or cobalamin metabolism are far from being understood. Moreover, innovative therapeutic strategies are needed for the treatment of neurological outcomes that are usually resistant to conventional treatments. Our previous findings suggest a link between SIRT1, cellular stress and RNA binding proteins (RBP) mislocalization in the pathological mechanisms triggered by impaired vitamin B12 metabolism.
Mots clés
Cognitive defect, Inherited defect, RNA binding protein, SIRT1, SRT1720, Vitamin B12
Référence
Metab. Clin. Exp.. 2019 Oct 28;:153992