Mao X, Gauche C, Coughtrie MW, Bui C, Gulberti S, Merhi-Soussi F, Ramalanjaona N, Bertin-Jung I, Diot A, Dumas D, De Freitas Caires N, Thompson AM, Bourdon JC, Ouzzine M, Fournel-Gigleux S

Oncogene. 2016 Sep;35(38):5043-55

Targeting of Proteoglycan Synthesis Pathway: A New Strategy to Counteract Excessive Matrix Proteoglycan Deposition and Transforming Growth Factor-β1-Induced Fibrotic Phenotype in Lung Fibroblasts.

Shaukat I, Barré L, Venkatesan N, Li D, Jaquinet JC, Fournel-Gigleux S, Ouzzine M

PLoS ONE. 2016 ;11(1):e0146499

Probing the acceptor active site organization of the human recombinant beta1,4-galactosyltransferase 7 and design of xyloside-based inhibitors.

Saliba M, Ramalanjaona N, Gulberti S, Bertin-Jung I, Thomas A, Dahbi S, Lopin-Bon C, Jacquinet JC, Breton C, Ouzzine M, Fournel-Gigleux S

J Biol Chem. 2015 Mar 20;290(12):7658-70

Glycosyltransferases and glycosaminoglycans in bleomycin and transforming growth factor-beta1-induced pulmonary fibrosis.

Venkatesan N, Tsuchiya K, Kolb M, Farkas L, Bourhim M, Ouzzine M, Ludwig MS

Am J Respir Cell Mol Biol. 2014 Mar;50(3):583-94

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication.

Ouzzine M, Gulberti S, Ramalanjaona N, Magdalou J, Fournel-Gigleux S

Front Cell Neurosci. 2014 Oct 28;8:349

Regulation of xylosyltransferase I gene expression by interleukin 1beta in human primary chondrocyte cells: mechanism and impact on proteoglycan synthesis.

Khair M, Bourhim M, Barre L, Li D, Netter P, Magdalou J, Fournel-Gigleux S, Ouzzine M

J Biol Chem. 2013 Jan 18;288(3):1774-84

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity.

Gulberti S, Jacquinet JC, Chabel M, Ramalanjaona N, Magdalou J, Netter P, Coughtrie MW, Ouzzine M, Fournel-Gigleux S

Glycobiology. 2012 Apr;22(4):561-71

Proteoglycans and cartilage repair.

Ouzzine M, Venkatesan N, Fournel-Gigleux S

Methods Mol Biol. 2012;836:339-55.

Xylosyltransferase-I regulates glycosaminoglycan synthesis during the pathogenic process of human osteoarthritis.

Venkatesan N, Barre L, Bourhim M, Magdalou J, Mainard D, Netter P, Fournel-Gigleux S, Ouzzine M

PLoS One. 2012;7(3):e34020

Increased deposition of chondroitin/dermatan sulfate glycosaminoglycan and upregulation of beta1,3-glucuronosyltransferase I in pulmonary fibrosis.

Venkatesan N, Ouzzine M, Kolb M, Netter P, Ludwig MS

Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L191-203

Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway.

Talhaoui I, Bui C, Oriol R, Mulliert G, Gulberti S, Netter P, Coughtrie MW, Ouzzine M, Fournel-Gigleux S

J Biol Chem. 2010 Nov 26;285(48):37342-58

Molecular characterization of beta1,4-galactosyltransferase 7 genetic mutations linked to the progeroid form of Ehlers-Danlos syndrome (EDS).

Bui C, Talhaoui I, Chabel M, Mulliert G, Coughtrie MW, Ouzzine M, Fournel-Gigleux S

FEBS Lett. 2010 Sep 24;584(18):3962-8

Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells.

Bui C, Ouzzine M, Talhaoui I, Sharp S, Prydz K, Coughtrie MW, Fournel-Gigleux S

FASEB J. 2010 Feb;24(2):436-50

Insights on membrane topology and structure/function of UDP-glucuronosyltransferases.

Magdalou J, Fournel-Gigleux S, Ouzzine M

Drug Metab Rev. 2010;42(1):154-61.

The use of hepatocytes to investigate UDP-glucuronosyltransferases and sulfotransferases.

Fournel-Gigleux S, Coughtrie MW, Ouzzine M, Magdalou J

Methods Mol Biol. 2010;640:309-26.

Modulation of xylosyltransferase I expression provides a mechanism regulating glycosaminoglycan chain synthesis during cartilage destruction and repair.

Venkatesan N, Barre L, Magdalou J, Mainard D, Netter P, Fournel-Gigleux S, Ouzzine M

FASEB J. 2009 Mar;23(3):813-22

[Agrecan and articular cartilage: assessment of glycosyltransferases for the restoration of cartilage matrix in osteoarthritis]

Magdalou J, Netter P, Fournel-Gigleux S, Ouzzine M

J Soc Biol. 2008;202(4):281-8

Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.

Barre L, Fournel-Gigleux S, Finel M, Netter P, Magdalou J, Ouzzine M

FEBS J. 2007 Mar;274(5):1256-64

[Chondrocyte glycosyltransferases: new pharmacological targets for degenerative diseases of articular cartilage?].

Magdalou J, Ouzzine M, Netter P, Fournel-Gigleux S

Bull Acad Natl Med. 2006 Oct;190(7):1385-97; discussion 1397-8, 1475-7.

Phylogenetic and mutational analyses reveal key residues for UDP-glucuronic acid binding and activity of beta1,3-glucuronosyltransferase I (GlcAT-I).

Fondeur-Gelinotte M, Lattard V, Oriol R, Mollicone R, Jacquinet JC, Mulliert G, Gulberti S, Netter P, Magdalou J, Ouzzine M, Fournel-Gigleux S

Protein Sci. 2006 Jul;15(7):1667-78.

Purification and characterization of a soluble form of the recombinant human galactose-beta1,3-glucuronosyltransferase I expressed in the yeast Pichia pastoris.

Lattard V, Fondeur-Gelinotte M, Gulberti S, Jacquinet JC, Boudrant J, Netter P, Magdalou J, Ouzzine M, Fournel-Gigleux S

Protein Expr Purif. 2006 May;47(1):137-43

Role of the carboxyl terminal stop transfer sequence of UGT1A6 membrane protein in ER targeting and translocation of upstream lumenal domain.

Ouzzine M, Barre L, Netter P, Magdalou J, Fournel-Gigleux S

FEBS Lett. 2006 Apr 3;580(8):1953-8

Modifications of the glycosaminoglycan-linkage region of proteoglycans: phosphorylation and sulfation determine the activity of the human beta1,4-galactosyltransferase 7 and beta1,3-glucuronosyltransferase I.

Gulberti S, Lattard V, Fondeur M, Jacquinet JC, Mulliert G, Netter P, Magdalou J, Ouzzine M, Fournel-Gigleux S

ScientificWorldJournal. 2005 Jul 12;5:510-4.

The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues.

Ouzzine M, Gulberti S, Levoin N, Netter P, Magdalou J, Fournel-Gigleux S

J Biol Chem. 2002 Jul 12;277(28):25439-45