Neoadjuvant chemotherapy for obstructive colon cancer derived by a stoma: Study protocol of the FRENCH-01 randomized phase III trial (COnCERTO Trial).

Fiche publication

Date publication

avril 2026

Journal

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Auteurs

Membres identifiés du Cancéropôle Est :
Dr ROMAIN Benoit , Pr GERMAIN Adeline , Dr LAKKIS Zaher

Tous les auteurs :
Bridoux V, Fernandez B, Sabbagh C, Hitier M, Kepenekian V, Amroun KL, Bouquot M, Lakkis Z, Ouaissi M, Darrius R, Dubreuil O, Duchalais E, Moreno-Lopez N, Trilling B, Zemour J, Beyer L, Alves A, Mauvais F, Noullet S, Romero R, Tresallet C, Badic B, Benoist S, Eveno C, Jeune F, Germain A, Duffas JP, Lefevre JH, Maggiori L, Manceau G, Marchese U, Mege D, Flesch H, Romain B, Tourreau Y, Zerbib P, Vychnevskaia K, Karoui M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41945039

Résumé

Obstructive colon cancer (OCC) is at poor prognosis, and the high morbidity of emergency resection frequently delays or precludes adjuvant chemotherapy. A strategy with first step diverting stoma - neoadjuvant chemotherapy (NAC) - colectomy in non-metastatic OCC may represent an alternative to the conventional strategy of stoma followed by colectomy.