Deciphering human endogenous retrovirus expression in colorectal cancers: exploratory analysis regarding prognostic value in liver metastases.

Date publication

mai 2025

Journal

EBioMedicine

Auteurs

Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier , Dr ARNOULD Laurent , Pr BORG Christophe , Mr MONNIEN Franck , Dr VERNEREY Dewi , Dr VIENOT Angélique , Dr LOYON Romain , Dr SELMANI Zohair

Tous les auteurs :
Viot J, Loyon R, Adib N, Laurent-Puig P, de Reyniès A, André F, Monnien F, André T, Svrcek M, Turpin A, Selmani Z, Arnould L, Guyard L, Gilbert N, Boureux A, Adotevi O, Vienot A, Abdeljaoued S, Vernerey D, Borg C, Gautheret D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40381378

Résumé

Human Endogenous RetroVirus (HERV) expression in tumours reflects epigenetic dysregulation of cancer and an oncogenic factor through promoter/enhancer action on genes. While more than 50% of colorectal cancers develop liver metastases, HERV has not been studied in this context.

Mots clés

Colorectal cancer, Endogenous retrovirus, Immunology, Liver metastases, Transposable elements

Référence

EBioMedicine. 2025 05 16;116:105727