Mr MONNIEN Franck

Fiche personne

Coordonnées

Service d'anatomie pathologique
Hôpital Jean Minjoz
2 bd Fleming
25030 BESANCON Cedex

03 81 66 89 66

Territoire

Franche-Comté

Statut

Ingénieur/Technicien

Affiliation

Centre hospitalier régional universitaire de Besançon (CHRU Besançon)

Équipes/plateformes

CRB - Tumorothèque régionale de Franche-Comté

Recherche

Expertises :
- Plateforme:Tumorothèque

Publications

Pivekimab sunirine in blastic plasmacytoid dendritic cell neoplasm: assessing spatial response and unraveling resistance mechanisms.

Poussard M, Boichut M, Belakri I, Biichle S, Fredon M, Cael B, Roussel X, Renosi F, Van Moer K, Janji B, Monnien F, Boichut C, Boidot R, Ndao B, Adotevi O, Garnache-Ottou F, Watkins K, Lakshmikanthan S, Angelot-Delettre F

Haematologica. 2026 02 5;:

Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery.

Abdeljaoued S, Doussot A, Kroemer M, Laloy E, Pallandre JR, El Kaddissi A, Spehner L, Ben Khelil M, Bouard A, Mougey V, Chartral U, Vienot A, Viot J, Lakkis Z, Monnien F, Loyon R, Borg C

Oncoimmunology. 2025 12;14(1):2455176

Dynamic DNA methylation changes during colorectal oncogenesis with insights from adenoma stages.

Overs A, Molimard C, Durand J, Bibeau F, Arnould L, Monnien F, Clavier C, Borg C, Guittaut M, Feugeas JP, Hervouet E, Peixoto P, Selmani Z

Sci Rep. 2025 11 25;:

Human papillomavirus infection is a favorable prognostic factor for patients with stage I-IVA esophageal squamous cell carcinoma but not adenocarcinoma.

Reynders C, Bruyere D, Roncarati P, Geuzaine R, Koopmansch B, Gofflot S, Monnien F, Craciun L, Piazzon N, Hendrick E, Poulain F, Lerho T, Miceli S, Pilard C, Ancion M, Luyckx M, Renard M, Lambert F, Gheit T, Molimard C, Bibeau F, Larsimont D, Fasquelle F, de Leval L, Delvenne P, Kervarrec T, Hubert P, Peulen O, Herfs M

Mod Pathol. 2025 07 28;:100853

Deciphering human endogenous retrovirus expression in colorectal cancers: exploratory analysis regarding prognostic value in liver metastases.

Viot J, Loyon R, Adib N, Laurent-Puig P, de Reyniès A, André F, Monnien F, André T, Svrcek M, Turpin A, Selmani Z, Arnould L, Guyard L, Gilbert N, Boureux A, Adotevi O, Vienot A, Abdeljaoued S, Vernerey D, Borg C, Gautheret D

EBioMedicine. 2025 05 16;116:105727

Analysis of gut homing receptors in circulating MAIT cells and their presence in synovial tissue from patients with axial spondyloarthritis.

Toussirot É, Ramon A, Laheurte C, Gravelin E, Vauchy C, Monnien F, Puyraveau M, Samson M, Saas P

J Rheumatol. 2025 05 15;:

Characterization and clinical outcomes of rare biliary adenosquamous carcinoma.

Ruffat A, Monnien F, Molimard C, Henriques J, Fein F, Doussot A, Vuitton L, Borg C, Vienot A

Eur J Surg Oncol. 2025 04 5;51(8):110015

Deep Multiple Instance Learning Model to Predict Outcome of Pancreatic Cancer Following Surgery.

Truntzer C, Ouahbi D, Huppé T, Rageot D, Ilie A, Molimard C, Beltjens F, Bergeron A, Vienot A, Borg C, Monnien F, Bibeau F, Derangère V, Ghiringhelli F

Biomedicines. 2024 12 2;12(12):

Reappraisal of Oncocytic Adenocarcinoma: Unveiling Its Connection to Oncocytic Variants of Salivary Duct Carcinoma and Mucoepidermoid Carcinoma Through ImmunoHisto-Molecular Perspectives.

Vial L, Descotes F, Lopez J, Alsugair Z, Céruse P, Philouze P, Fieux M, Wassef M, Baglin AC, Onea M, Castain C, Delvenne P, Fromont-Hankard G, Gilles H, Monnien F, Mauvais O, Lépine C, Le Gall F, Rousselet MC, Sudaka A, Uro-Coste E, Casiraghi O, Costes-Martineau V, Benzerdjeb N,

Am J Surg Pathol. 2024 11 8;:

COL25A1 and METAP1D DNA methylation are promising liquid biopsy epigenetic biomarkers of colorectal cancer using digital PCR.

Overs A, Peixoto P, Hervouet E, Molimard C, Monnien F, Durand J, Guittaut M, Vienot A, Viot J, Herfs M, Borg C, Feugeas JP, Selmani Z

Clin Epigenetics. 2024 10 18;16(1):146

The level of expression of HPV16 early transcripts is not associated with the natural history of cervical lesions.

Jacquin E, Saunier M, Lepiller Q, Monnien F, Mauny F, Ramanah R, Carcopino X, Riethmuller D, Mougin C, Prétet JL

J Med Virol. 2024 09;96(9):e29875

Concomitant decrease of E- and A-FABP expression predicts worse survival in urothelial bladder cancer patients.

Saizonou I, Lascombe I, Monnien F, Bedgedjian I, Kleinclauss F, Algros MP, Fauconnet S

Sci Rep. 2024 07 4;14(1):15390

Temporal and spatial heterogeneity of HER2 status in metastatic colorectal cancer.

D'Angelo F, Monnien F, Overs A, Pem I, Dor F, Abad M, Felix S, Selmani Z, Lakkis Z, Borg C, Doussot A, Bibeau F, Molimard C

Diagn Pathol. 2024 06 22;19(1):88

Prognostic Factors for Long-Term Eribulin Response in a Cohort of Patients With HER2-Negative Metastatic Breast Cancer.

El Kaddissi A, Vernerey D, Falcoz A, Mansi L, Bazan F, Chaigneau L, Dobi E, Goujon M, Meneveau N, Paillard MJ, Selmani Z, Viot J, Molimard C, Monnien F, Woronoff AS, Curtit E, Borg C, Meynard G

Clin Breast Cancer. 2024 06 19;:

CD3-CD8 immune score associated with a clinical score stratifies PDAC prognosis regardless of adjuvant or neoadjuvant chemotherapy.

Schoumacher C, Derangère V, Gaudillière-Le Dain G, Huppe T, Rageot D, Ilie A, Vienot A, Borg C, Monnien F, Bibeau F, Truntzer C, Ghiringhelli F,

Oncoimmunology. 2023 12 21;13(1):2294563

Evaluation of immune infiltrate according to the HER2 status in colorectal cancer.

Molimard C, Dor F, Overs A, Monnien F, Gessain G, Kedochim L, D'Angelo F, Abad M, Heberle M, Derangère V, Ghiringhelli F, Vuitton L, Valmary-Degano S, Borg C, Lakkis Z, Bibeau F

Dig Liver Dis. 2023 10 14;:

Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells.

El Baba R, Haidar Ahmad S, Monnien F, Mansar R, Bibeau F, Herbein G

Oncogene. 2023 08 26;:

Should the artery be trimmed before anastomosis in every finger replantation/revascularization case? Prospective, single-center, multidisciplinary study over 46 months.

Pichonnat M, Buffet A, Monnien F, Aubry S, Pluvy I, Loisel F, Obert L, Degano SV, Guerzider IR

Orthop Traumatol Surg Res. 2023 06 23;:103646

Real-time multiplex PCR for human echinococcosis and differential diagnosis.

Knapp J, Lallemand S, Monnien F, Felix S, Courquet S, Umhang G, Millon L

Parasite. 2023 01 25;30:3

Molecular diagnosis of alveolar echinococcosis in patients based on frozen and formalin-fixed paraffin-embedded tissue samples.

Knapp J, Lallemand S, Monnien F, Felix S, Valmary-Degano S, Courquet S, Demonmerot F, Heyd B, Turco C, Doussot A, Bourgeois L, Bresson-Hadni S, Richou C, Millon L

Parasite. 2022 ;29:4

Polyploid giant cancer cells, stemness and epithelial-mesenchymal plasticity elicited by human cytomegalovirus.

Nehme Z, Pasquereau S, Haidar Ahmad S, Coaquette A, Molimard C, Monnien F, Algros MP, Adotevi O, Diab Assaf M, Feugeas JP, Herbein G

Oncogene. 2021 Mar 25;:

Identification of UL69 Gene and Protein in Cytomegalovirus-Transformed Human Mammary Epithelial Cells.

Haidar Ahmad S, Al Moussawi F, El Baba R, Nehme Z, Pasquereau S, Kumar A, Molimard C, Monnien F, Algros MP, Karaky R, Stamminger T, Diab Assaf M, Herbein G

Front Oncol. 2021 ;11:627866

Autophagy is associated with a robust specific transcriptional signature in breast cancer subtypes.

Grandvallet C, Feugeas JP, Monnien F, Despouy G, Valérie P, Michaël G, Hervouet E, Peixoto P

Genes Cancer. 2020 Dec 31;11(3-4):154-168

Immunohistochemistry with anti-MAL antibody and RNAscope with MAL probes are complementary techniques for diagnosis of primary mediastinal large B-cell lymphoma.

Jacquier A, Syrykh C, Bedgedjian I, Monnien F, Laurent C, Valmary-Degano S, Brousset P

J. Clin. Pathol.. 2020 Aug 24;:

Treatment algorithm and prognostic factors for patients with stage I-III carcinoma of the anal canal: a 20-year multicenter study.

Bruyere D, Monnien F, Colpart P, Roncarati P, Vuitton L, Hendrick E, Lepinoy A, Luquain A, Pilard C, Lerho T, Molimard C, Maingon P, Arnould L, Bone-Lepinoy MC, Dusserre L, Martin L, Reynders C, Ancion M, Peiffert D, Leroux A, Hubert P, Delhorme JB, Ghnassia JP, Woronoff AS, Delvenne P, Prétet JL, Bosset JF, Peulen O, Mougin C, Valmary-Degano S, Herfs M

Mod. Pathol.. 2020 Jul 29;:

Comparison of Molecular and Histologic Ultrastaging Methods in Sentinel Lymph Node Analysis from Clinical Stage II Colon Cancers.

Deroo O, Lakkis Z, Paquette B, Grand D, Monnien F, Felix S, Borg C, Heyd B, Kim S, Valmary-Degano S

Appl. Immunohistochem. Mol. Morphol.. 2019 Aug;27(7):e65-e70

["Discovering Pathology", a serious game dedicated to the discovery of pathology for medical students].

Jacquier A, Briot M, Barillot G, Deroo O, Monnien F, Hurlot Q, Frenois FX, Aubin F, Degano B, Reffay C, Valmary-Degano S

Ann Pathol. 2019 Jan 28;:

Down-regulation of A-FABP predicts non-muscle invasive bladder cancer progression: investigation with a long term clinical follow-up.

Mathis C, Lascombe I, Monnien F, Bittard H, Kleinclauss F, Bedgedjian I, Fauconnet S, Valmary-Degano S

BMC Cancer. 2018 Dec 10;18(1):1239

Is Overexpressed in Triple Negative Breast Cancer and Its In Vitro Extinction Leads to the Inhibition of Pro-Cancer Phenotypes.

Claude-Taupin A, Fonderflick L, Gauthier T, Mansi L, Pallandre JR, Borg C, Perez V, Monnien F, Algros MP, Vigneron M, Adami P, Delage-Mourroux R, Peixoto P, Herfs M, Boyer-Guittaut M, Hervouet E

Cells. 2018 Dec 6;7(12):

A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

Herfs M, Roncarati P, Koopmansch B, Peulen O, Bruyere D, Lebeau A, Hendrick E, Hubert P, Poncin A, Penny W, Piazzon N, Monnien F, Guenat D, Mougin C, Prétet JL, Vuitton L, Segers K, Lambert F, Bours V, de Leval L, Valmary-Degano S, Quick CM, Crum CP, Delvenne P

Br. J. Cancer. 2018 Apr 27;:

Pediatric Chordomas: Results of a Multicentric Study of 40 Children and Proposal for a Histopathological Prognostic Grading System and New Therapeutic Strategies.

Beccaria K, Tauziède-Espariat A, Monnien F, Adle-Biassette H, Masliah-Planchon J, Pierron G, Maillot L, Polivka M, Laquerrière A, Bouillot-Eimer S, Gimbert E, Gauchotte G, Coffinet L, Sevestre H, Alapetite C, Bolle S, Thompson D, Zérah M, Sainte-Rose C, Puget S, Varlet P

J. Neuropathol. Exp. Neurol.. 2018 Mar 1;77(3):207-215

Immunohistochemical evaluation of two antibodies against PD-L1 and prognostic significance of PD-L1 expression in epithelioid peritoneal malignant mesothelioma: A RENAPE study.

Valmary-Degano S, Colpart P, Villeneuve L, Monnien F, M'Hamdi L, Lang Averous G, Capovilla M, Bibeau F, Laverriere MH, Verriele-Beurrier V, Ben Rejeb H, Dartigues P, Hommell-Fontaine J, Gilly FN, Isaac S, Mery E,

Eur J Surg Oncol. 2017 May;:

Loss of smarce1 expression is a specific diagnostic marker of clear cell meningioma: A comprehensive immunophenotypical and molecular analysis.

Tauziede-Espariat A, Parfait B, Besnard A, Lacombe J, Pallud J, Tazi S, Puget S, Lot G, Terris B, Cohen J, Vidaud M, Figarella-Branger D, Monnien F, Polivka M, Adle-Biassette H, Varlet P

Brain Pathol.. 2017 May;:

Human papillomaviruses in colorectal cancers: A case-control study in western patients.

Vuitton L, Jaillet C, Jacquin E, Monnien F, Heberle M, Mihai MI, Lassabe C, Raffoul J, Puyraveau M, Lakkis Z, Lamfichekh N, Picard A, Prétet JL, Mougin C, Valmary-Degano S

Dig Liver Dis. 2017 Apr;49(4):446-450

Somatic mutational spectrum analysis in a prospective series of 104 gastrointestinal stromal tumors.

Guenat D, Deroo O, Magnin S, Chaigneau L, Monnien F, Borg C, Mougin C, Emile JF, Prétet JL

Oncol. Rep.. 2017 Mar;37(3):1671-1681

[Authorization of pathologists for the estimation of the tumor cell percentage on tissue sample for molecular analysis purpose].

Luquain A, Arbez-Gindre F, Bedgedjian I, Felix S, Harimenshi JM, Mihai IM, Monnien F, Singeorzan C, Valmary-Degano S

Ann Pathol. 2016 Aug;36(4):268-74

Prognostic and Therapeutic Markers in Chordomas: A Study of 287 Tumors.

Tauziéde-Espariat A, Bresson D, Polivka M, Bouazza S, Labrousse F, Aronica E, Pretet JL, Projetti F, Herman P, Salle H, Monnien F, Valmary-Degano S, Laquerrière A, Pocard M, Chaigneau L, Isambert N, Aubriot-Lorton MH, Feuvret L, George B, Froelich S, Adle-Biassette H

J. Neuropathol. Exp. Neurol.. 2016 Feb;75(2):111-20

Prognostic Value of Angiopoietin-2 for death risk stratification in Patients with Metastatic Colorectal Carcinoma.

Jary M, Vernerey D, Lecomte T, Dobi E, Ghiringhelli F, Monnien F, Godet Y, Kim S, Bouche O, Fratte S, Goncalves A, Leger J, Queiroz L, Adotevi O, Bonnetain F, Borg C

Cancer Epidemiol Biomarkers Prev. 2015 Jan 12. pii: cebp.1059.2014.

The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models.

Hervouet E, Claude-Taupin A, Gauthier T, Perez V, Fraichard A, Adami P, Despouy G, Monnien F, Algros MP, Jouvenot M, Delage-Mourroux R, Boyer-Guittaut M

BMC Cancer. 2015 Oct 17;15:729

Advanced biliary tract carcinomas: a retrospective multicenter analysis of first and second-line chemotherapy.

Fiteni F, Jary M, Monnien F, Nguyen T, Beohou E, Demarchi M, Dobi E, Fein F, Cleau D, Fratte S, Nerich V, Bonnetain F, Pivot X, Borg C, Kim S

BMC Gastroenterol. 2014 Aug 13;14:143

Signature patterns of human papillomavirus type 16 in invasive anal carcinoma.

Valmary-Degano S, Jacquin E, Pretet JL, Monnien F, Girardo B, Arbez-Gindre F, Joly M, Bosset JF, Kantelip B, Mougin C

Hum Pathol. 2013 Jun;44(6):992-1002

Impact of STAT3 phosphorylation on the clinical effectiveness of anti-EGFR-based therapy in patients with metastatic colorectal cancer.

Dobi E, Monnien F, Kim S, Ivanaj A, N'Guyen T, Demarchi M, Adotevi O, Thierry-Vuillemin A, Jary M, Kantelip B, Pivot X, Godet Y, Degano SV, Borg C

Clin Colorectal Cancer. 2013 Mar;12(1):28-36

Bifractionated CPT-11 with LV5FU2 infusion (FOLFIRI-3) in combination with bevacizumab: clinical outcomes in first-line metastatic colorectal cancers according to plasma angiopoietin-2 levels.

Kim S, Dobi E, Jary M, Monnien F, Curtit E, Nguyen T, Lakkis Z, Heyd B, Fratte S, Cleau D, Lamfichekh N, Nerich V, Guiu B, Demarchi M, Borg C

BMC Cancer. 2013 Dec 27;13:611

Specific skin lesions in chronic myelomonocytic leukemia: a spectrum of myelomonocytic and dendritic cell proliferations: a study of 42 cases.

Vitte F, Fabiani B, Benet C, Dalac S, Balme B, Delattre C, Vergier B, Beylot-Barry M, Vignon-Pennamen D, Ortonne N, Algros MP, Carlotti A, Samaleire D, Frouin E, Levy A, Laroche L, Theate I, Monnien F, Mugneret F, Petrella T

Am J Surg Pathol. 2012 Sep;36(9):1302-16.