Yoshisada R, Zhang Y, Janssen E, Bouchard C, Poole DA, Wan T, Soares LR, Houtkamp IM, Abeln S, Mouhib H, van Haren MJ, Marechal N, Troffer-Charlier N, Cura V, Cavarelli J, van Ingen H, Bauer UM, Martin NI, Jongkees SAK

Chem Sci. 2026 02 25;:

Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.

Iannelli G, Milite C, Marechal N, Cura V, Bonnefond L, Troffer-Charlier N, Feoli A, Rescigno D, Wang Y, Cipriano A, Viviano M, Bedford MT, Cavarelli J, Castellano S, Sbardella G

J Med Chem. 2022 Apr 28;:

Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase.

Cura V, Cavarelli J

Life (Basel). 2021 Nov 19;11(11):

Structural studies provide new insights into the role of lysine acetylation on substrate recognition by CARM1 and inform the design of potent peptidomimetic inhibitors.

Zhang Y, Marechal N, van Haren M, Troffer-Charlier N, Cura V, Cavarelli J, Martin NI

Chembiochem. 2021 Sep 27;:

FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.

Di Mattia T, Martinet A, Ikhlef S, McEwen AG, Nominé Y, Wendling C, Poussin-Courmontagne P, Voilquin L, Eberling P, Ruffenach F, Cavarelli J, Slee J, Levine TP, Drin G, Tomasetto C, Alpy F

EMBO J. 2020 Oct 30;:e104369

Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation.

Salomon E, Schmitt M, Mouray E, McEwen AG, Bounaadja L, Torchy M, Poussin-Courmontagne P, Alavi S, Tarnus C, Cavarelli J, Florent I, Albrecht S

Bioorg. Chem.. 2020 Mar 11;98:103750

Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.

Halby L, Marechal N, Pechalrieu D, Cura V, Franchini DM, Faux C, Alby F, Troffer-Charlier N, Kudithipudi S, Jeltsch A, Aouadi W, Decroly E, Guillemot JC, Page P, Ferroud C, Bonnefond L, Guianvarc'h D, Cavarelli J, Arimondo PB

Philos. Trans. R. Soc. Lond., B, Biol. Sci.. 2018 Jun 5;373(1748):

Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis.

Peng G, McEwen AG, Olieric V, Schmitt C, Albrecht S, Cavarelli J, Tarnus C

Proteins. 2017 Apr;:

Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.

van Haren MJ, Marechal N, Troffer-Charlier N, Cianciulli A, Sbardella G, Cavarelli J, Martin NI

Proc. Natl. Acad. Sci. U.S.A.. 2017 Mar;:

SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.

Gribling-Burrer AS, Leichter M, Wurth L, Huttin A, Schlotter F, Troffer-Charlier N, Cura V, Barkats M, Cavarelli J, Massenet S, Allmang C

Nucleic Acids Res.. 2017 Jan;:

Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.

Cura V, Marechal N, Troffer-Charlier N, Strub JM, van Haren MJ, Martin NI, Cianférani S, Bonnefond L, Cavarelli J

FEBS J.. 2017 Jan;284(1):77-96

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.

Thébault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honoré J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianférani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J

Sci Rep. 2016 Jan;6:19725

Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.

Bonnefond L, Stojko J, Mailliot J, Troffer-Charlier N, Cura V, Wurtz JM, Cianferani S, Cavarelli J

J Struct Biol. 2015 Jun 18. pii: S1047-8477(15)30021-6

Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification.

Kolaj-Robin O, McEwen AG, Cavarelli J, Séraphin B

FEBS J.. 2015 Mar;282(5):819-33

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M

J Mol Biol. 2014 Oct 9;426(20):3442-53

Structural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active site.

Cura V, Troffer-Charlier N, Wurtz JM, Bonnefond L, Cavarelli J

Acta Crystallogr D Biol Crystallogr. 2014 Sep 1;70(Pt 9):2401-12

Cloning, expression, purification and preliminary X-ray crystallographic analysis of mouse protein arginine methyltransferase 7.

Cura V, Troffer-Charlier N, Lambert MA, Bonnefond L, Cavarelli J

Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):80-6

Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.

Zanier K, Charbonnier S, Sidi AO, McEwen AG, Ferrario MG, Poussin-Courmontagne P, Cura V, Brimer N, Babah KO, Ansari T, Muller I, Stote RH, Cavarelli J, Vande Pol S, Trave G

Science. 2013 Feb 8;339(6120):694-8

Identification of Small-Molecule Enhancers of Arginine Methylation Catalyzed by Coactivator-Associated Arginine Methyltransferase 1.

Castellano S, Spannhoff A, Milite C, Dal Piaz F, Cheng DH, Tosco A, Viviano M, Yamani A, Cianciulli A, Sala M, Cura V, Cavarelli J, Novellino E, Mai A, Bedford MT, Sbardella G

J Med Chem. 2012 Nov 26;55(22):9875-90