Dr LUTZ Pierre-Eric

Fiche personne

Coordonnées

INCI
8 allée du général Rouvillois
67000 STRASBOURG

Territoire

Alsace

Statut

Chercheur

Affiliation

Institut des neurosciences cellulaires et intégratives (INCI) - CNRS UPR 3212 (INCI)

Équipes/plateformes

CNRS UPR 3212 - Equipe "Douleur et psychopathologie"

Recherche

Thématique de recherche :

Signatures transcriptionnelles et épigénétique des opiacés

Biomarqueurs périphériques des troubles psychiatriqu

Projets

Décomposer les mécanismes épigénétiques cérébraux des polyconsommations

2022 - Porteur du projet : Dr LUTZ Pierre-Eric

Publications

A pathway from the anterior cingulate cortex to the lateral habenula controls chronic pain-induced depression in male mice.

Journée SH, Mathis VP, Waegaert R, Ozkan S, Langlois E, Ortiz-Teba P, Ayazgok B, Becker LJ, Gaikwad M, Barrot M, Hugel S, Harsan L, Lutz PE, Yalcin I

Neuropsychopharmacology. 2026 01 21;:

The DNA methylation enzymatic machinery in substance use disorders: A systematic review.

Diringer M, Bruggeman M, Lutz PE

Neurobiol Dis. 2025 12 22;:107241

Integrative exploration of bio-psycho-social determinants of DSM-5 severity levels of opioid use disorder: the BEBOP cohort study protocol.

Lalanne L, Lutz PE, Caparros-Roissard A, Ruppert E, Waeckerle G, Scherer C, Oster F, Brand C, Henck S, Soavelo H, Ramousset C, Lebreton M, Audran M, Lazic J, Detrez V, Avril E, Merah I, Chappuy M, Meyer N, Jauffret-Roustide M, Rolland B

BMJ Open. 2025 10 13;15(10):e093358

Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control study.

Mokhtari A, Ibrahim EC, Gloaguen A, Barrot CC, Cohen D, Derouin M, Vachon H, Charbonnier G, Loriod B, Decraene C, Yalcin I, Marie-Claire C, Etain B, Belzeaux R, Delahaye-Duriez A, Lutz PE

EBioMedicine. 2025 02 5;113:105569

Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies.

Falconnier C, Caparros-Roissard A, Decraene C, Lutz PE

Mol Psychiatry. 2023 09 15;:

Accelerated aging in bipolar disorders: An exploratory study of six epigenetic clocks.

Bourdon C, Etain B, Spano L, Belzeaux R, Leboyer M, Delahaye-Duriez A, Ibrahim EC, Lutz PE, Gard S, Schwan R, Polosan M, Courtet P, Passerieux C, Bellivier F, Marie-Claire C

Psychiatry Res. 2023 07 26;327:115373

Mu opioid receptor-positive neurons in the dorsal raphe nucleus are impaired by morphine abstinence.

Welsch L, Colantonio E, Falconnier C, Champagnol-DiLiberti C, Allain F, Ben Hamida S, Darcq E, Lutz PE, Kieffer BL

Biol Psychiatry. 2023 06 29;:

Can you remember silence? Epigenetic memory and reversibility as a site of intervention.

Lloyd S, Lutz PE, Bonventre C

Bioessays. 2023 05 11;:e2300019

The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice.

Becker LJ, Fillinger C, Waegaert R, Journée SH, Hener P, Ayazgok B, Humo M, Karatas M, Thouaye M, Gaikwad M, Degiorgis L, Santin MDN, Mondino M, Barrot M, Ibrahim EC, Turecki G, Belzeaux R, Veinante P, Harsan LA, Hugel S, Lutz PE, Yalcin I

Nat Commun. 2023 04 17;14(1):2198

Homeorhesis: envisaging the logic of life trajectories in molecular research on trauma and its effects.

Lloyd S, Larivée A, Lutz PE

Hist Philos Life Sci. 2022 11 22;44(4):65

The molecular pathophysiology of mood disorders: From the analysis of single molecular layers to multi-omic integration.

Mokhtari A, Porte B, Belzeaux R, Etain B, Ibrahim EC, Marie-Claire C, Lutz PE, Delahaye-Duriez A

Prog Neuropsychopharmacol Biol Psychiatry. 2022 06 8;116:110520

Oxytocin receptor expression and epigenetic regulation in the anterior cingulate cortex of individuals with a history of severe childhood abuse.

Almeida D, Fiori LM, Chen GG, Aouabed Z, Lutz PE, Zhang TY, Mechawar N, Meaney MJ, Turecki G

Psychoneuroendocrinology. 2022 02;136:105600

Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals.

Lutz PE, Almeida D, Filliol D, Jollant F, Kieffer BL, Turecki G

Neuropsychopharmacology. 2021 04;46(5):920-927

Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation.

Lutz PE, Chay MA, Pacis A, Chen GG, Aouabed Z, Maffioletti E, Théroux JF, Grenier JC, Yang J, Aguirre M, Ernst C, Redensek A, van Kempen LC, Yalcin I, Kwan T, Mechawar N, Pastinen T, Turecki G

Nat Commun. 2021 02 18;12(1):1132

Comorbidity of chronic pain and anxiodepressive disorders: Deciphering underlying brain circuits.

Becker LJ, Journée SH, Lutz PE, Yalcin I

Neurosci Biobehav Rev. 2020 08;115:131-133

Neural and molecular correlates of psychological pain during major depression, and its link with suicidal ideas.

Jollant F, Perreira F, Fiori LM, Richard-Devantoy S, Lutz PE, Belzeaux R, Turecki G

Prog Neuropsychopharmacol Biol Psychiatry. 2020 06 8;100:109909

Suicide and suicide behaviors: A review of transcriptomics and multiomics studies in psychiatric disorders.

Zhou Y, Lutz PE, Ibrahim EC, Courtet P, Tzavara E, Turecki G, Belzeaux R

J Neurosci Res. 2020 04;98(4):601-615

The opioid system and the social brain: implications for depression and suicide.

Lutz PE, Courtet P, Calati R

J Neurosci Res. 2020 04;98(4):588-600

The Role of Opiates in Social Pain and Suicidal Behavior.

Nobile B, Lutz PE, Olie E, Courtet P

Curr Top Behav Neurosci. 2020 ;46:197-210

Stalled developmental programs at the root of pediatric brain tumors.

Jessa S, Blanchet-Cohen A, Krug B, Vladoiu M, Coutelier M, Faury D, Poreau B, De Jay N, Hébert S, Monlong J, Farmer WT, Donovan LK, Hu Y, McConechy MK, Cavalli FMG, Mikael LG, Ellezam B, Richer M, Allaire A, Weil AG, Atkinson J, Farmer JP, Dudley RWR, Larouche V, Crevier L, Albrecht S, Filbin MG, Sartelet H, Lutz PE, Nagy C, Turecki G, Costantino S, Dirks PB, Murai KK, Bourque G, Ragoussis J, Garzia L, Taylor MD, Jabado N, Kleinman CL

Nat Genet. 2019 12;51(12):1702-1713

Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides.

Tanti A, Lutz PE, Kim J, O'Leary L, Théroux JF, Turecki G, Mechawar N

Neuropsychopharmacology. 2019 11;44(12):2099-2111

Epigenetic Regulation of the Kappa Opioid Receptor by Child Abuse.

Lutz PE, Gross JA, Dhir SK, Maussion G, Yang J, Bramoulle A, Meaney MJ, Turecki G

Biol Psychiatry. 2018 11 15;84(10):751-761

A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.

Kremer M, Yalcin I, Goumon Y, Wurtz X, Nexon L, Daniel D, Megat S, Ceredig RA, Ernst C, Turecki G, Chavant V, Théroux JF, Lacaud A, Joganah LE, Lelievre V, Massotte D, Lutz PE, Gilsbach R, Salvat E, Barrot M

J. Neurosci.. 2018 Nov 14;38(46):9934-9954

Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides.

Zhou Y, Lutz PE, Wang YC, Ragoussis J, Turecki G

Transl Psychiatry. 2018 10 18;8(1):224

Transcriptomic and epigenomic biomarkers of antidepressant response.

Belzeaux R, Lin R, Ju C, Chay MA, Fiori LM, Lutz PE, Turecki G

J Affect Disord. 2018 06;233:36-44

Plasticity of the epigenome during early-life stress.

Burns SB, Szyszkowicz JK, Luheshi GN, Lutz PE, Turecki G

Semin Cell Dev Biol. 2018 05;77:115-132

Hyperactivity of Anterior Cingulate Cortex Areas 24a/24b Drives Chronic Pain-Induced Anxiodepressive-like Consequences.

Sellmeijer J, Mathis V, Hugel S, Li XH, Song Q, Chen QY, Barthas F, Lutz PE, Karatas M, Luthi A, Veinante P, Aertsen A, Barrot M, Zhuo M, Yalcin I

J Neurosci. 2018 03 21;38(12):3102-3115

Epigenetic regulation of the kappa opioid receptor gene by an insertion-deletion in the promoter region.

Lutz PE, Almeida D, Belzeaux R, Yalcin I, Turecki G

Eur Neuropsychopharmacol. 2018 02;28(2):334-340

Focusing on the Opioid System for Addiction Biomarker Discovery.

Belzeaux R, Lalanne L, Kieffer BL, Lutz PE

Trends Mol Med. 2018 02;24(2):206-220

Association of a History of Child Abuse With Impaired Myelination in the Anterior Cingulate Cortex: Convergent Epigenetic, Transcriptional, and Morphological Evidence.

Lutz PE, Tanti A, Gasecka A, Barnett-Burns S, Kim JJ, Zhou Y, Chen GG, Wakid M, Shaw M, Almeida D, Chay MA, Yang J, Larivière V, M'Boutchou MN, van Kempen LC, Yerko V, Prud'homme J, Davoli MA, Vaillancourt K, Théroux JF, Bramoullé A, Zhang TY, Meaney MJ, Ernst C, Côté D, Mechawar N, Turecki G

Am J Psychiatry. 2017 12 1;174(12):1185-1194

Neuropathology of suicide: recent findings and future directions.

Lutz PE, Mechawar N, Turecki G

Mol Psychiatry. 2017 10;22(10):1395-1412

Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence.

Lalanne L, Ayranci G, Filliol D, Gavériaux-Ruff C, Befort K, Kieffer BL, Lutz PE

Addict Biol. 2017 07;22(4):1010-1021

Acute impact of caffeinated alcoholic beverages on cognition: A systematic review.

Lalanne L, Lutz PE, Paille F

Prog Neuropsychopharmacol Biol Psychiatry. 2017 06 2;76:188-194

Gene-body 5-hydroxymethylation is associated with gene expression changes in the prefrontal cortex of depressed individuals.

Gross JA, Pacis A, Chen GG, Drupals M, Lutz PE, Barreiro LB, Turecki G

Transl Psychiatry. 2017 05 9;7(5):e1119

Medium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine.

Chen GG, Gross JA, Lutz PE, Vaillancourt K, Maussion G, Bramoulle A, Théroux JF, Gardini ES, Ehlert U, Bourret G, Masurel A, Lepage P, Mechawar N, Turecki G, Ernst C

BMC Genomics. 2017 01 18;18(1):96