Dr DORMOY Valerian

α5 Nicotinic Receptor Polymorphism affects cigarette smoke-induced inflammation and COPD development.

Massara L, Saber Cherif L, Ollivier A, Kervoaze G, Pichavant M, Dufossez C, Fawaz A, Leprêtre E, Le Rouzic O, Deslée G, Pons S, Maskos U, Dormoy V, Gosset P

Am J Respir Cell Mol Biol. 2026 05 4;:

Identification and validation of cilia-associated molecular candidates deregulated in severe asthma.

Devilliers MA, Saber Cherif L, Brisebarre A, Chouquet R, Bralet L, Ancel J, Vivien A, Luczka-Majérus E, Bonnomet A, Lalun N, Taillé C, Dubernard X, Mérol JC, Ruaux C, Polette M, Deslée G, Perotin JM, Dormoy V

Respir Res. 2026 02 9;:

AXL expression to predict resistance to immunotherapy in metastatic non-small cell lung cancer.

Ancel J, Dewolf M, Nawrocki-Raby B, Durlach A, Dalstein V, Lalun N, Dormoy V, Deslée G, Gilles C, Polette M

Lung Cancer. 2025 11 22;210:108853

POU5F1 bridges Hedgehog signaling and epithelial remodeling in COPD.

Petit LMG, Belgacemi R, Mulette P, Brisebarre A, Saber Cherif L, Devilliers MA, Hatoum S, Ancel J, Delepine G, Durlach A, Polette M, Deslée G, Perotin JM, Dormoy V

Front Cell Dev Biol. 2025 07 2;13:1566251

Evaluation of the Smoking Exposure Effects on Carcinogenesis Markers According to the Localization of Melanocytic Lesions.

Batut L, Sanchez S, Lalun N, Saber Cherif L, Bouland N, Durlach A, Dormoy V

Exp Dermatol. 2025 05;34(5):e70111

Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis.

Simmalee K, Lumjiaktase P, Kawamatawong T, Guemari A, Dormoy V, Vitte J

Front Immunol. 2025 04 11;16:1568541

Glypican-3 is a key tuner of the Hedgehog pathway in COPD.

Petit LMG, Saber Cherif L, Devilliers MA, Hatoum S, Ancel J, Delepine G, Durlach A, Dubernard X, Mérol JC, Ruaux C, Polette M, Deslée G, Perotin JM, Dormoy V

Heliyon. 2025 01 15;11(1):e41564

TSLP and TSLPr Expression and Localization in the Airways of COPD and Non-COPD Patients.

Saber Cherif L, Devilliers MA, Perotin JM, Ancel J, Vivien A, Bonnomet A, Delepine G, Durlach A, Polette M, Deslée G, Dormoy V

Eur J Immunol. 2025 01;55(1):e202451480

Peribronchial Inflammatory Cell Assessment in COPD Lung Tissues.

Devilliers MA, Saber Cherif L, Petit LMG, Lalun N, Bonnomet A, Durlach A, Delepine G, Polette M, Perotin JM, Deslée G, Dormoy V

J Cell Mol Med. 2024 11;28(22):e70229

Obesity Impact on Dyspnea in COPD Patients.

Dupuis A, Thierry A, Perotin JM, Ancel J, Dormoy V, Dury S, Deslée G, Launois C

Int J Chron Obstruct Pulmon Dis. 2024 07 22;19:1695-1706

High Blood Eosinophil Count at Stable State is Not Associated with Airway Microbiota Distinct Profile in COPD.

Perotin JM, Muggeo A, Lecomte-Thenot Q, Brisebarre A, Dury S, Launois C, Ancel J, Dormoy V, Guillard T, Deslee G

Int J Chron Obstruct Pulmon Dis. 2024 03 18;19:765-771

Patient education needs in severe asthma, a pilot study.

Laurence R, Ancel J, Devilliers MA, Carre S, Dury S, Dormoy V, Deslée G, Perotin JM

BMC Pulm Med. 2024 03 15;24(1):134

Airway epithelial cell cilia transcriptomic dysregulation is associated with the inflammatory phenotype in asthma.

Devilliers MA, Brisebarre A, Petit LMG, Polette M, Deslée G, Djukanović R, Dormoy V, Perotin JM,

Allergy. 2024 02 19;:

Bronchiectasis in renal transplant patients: a cross-sectional study.

Mulette P, Perotin JM, Muggeo A, Guillard T, Brisebarre A, Meyer H, Hagenburg J, Ancel J, Dormoy V, Vuiblet V, Launois C, Lebargy F, Deslee G, Dury S

Eur J Med Res. 2024 02 13;29(1):120

Airway ciliated cells in adult lung homeostasis and COPD.

Petit LMG, Belgacemi R, Ancel J, Saber Cherif L, Polette M, Perotin JM, Spassky N, Pilette C, Al Alam D, Deslée G, Dormoy V

Eur Respir Rev. 2023 12 31;32(170):

Current cough and sputum assessed by the cough and sputum assessment-questionnaire (CASA-Q) is associated with quality of life impairment in cystic fibrosis.

Charon L, Launois C, Perotin JM, Ravoninjatovo B, Mulette P, Ancel J, Guillard T, Muggeo A, Dormoy V, Griffon M, Carré S, Lebargy F, Deslée G, Dury S

BMC Pulm Med. 2023 11 21;23(1):457

Soluble biomarkers to predict clinical outcomes in non-small cell lung cancer treated by immune checkpoints inhibitors.

Ancel J, Dormoy V, Raby BN, Dalstein V, Durlach A, Dewolf M, Gilles C, Polette M, Deslée G

Front Immunol. 2023 05 22;14:1171649

Transcriptomic FHIT/pHER2 signature as a predictive factor of outcome and immunotherapy response in non-small cell lung cancer.

Brisebarre A, Ancel J, Ponchel T, Loeffler E, Germain A, Dalstein V, Dormoy V, Durlach A, Delepine G, Deslée G, Polette M, Nawrocki-Raby B

Front Immunol. 2022 12 5;13:1058531

Ciliogenesis is intrinsically altered in COPD small airways.

Luczka-Majérus E, Bonnomet A, Germain A, Lalun N, Kileztky C, Perotin JM, Deslée G, Delepine G, Polette M, Dormoy V, Coraux C

Eur Respir J. 2022 11 17;:

Tracheobronchopathia osteochondroplastica: clinical, bronchoscopic, and comorbid features in a case series.

Dumazet A, Launois C, Lebargy F, Kessler R, Vallerand H, Schmitt P, Hermant C, Dury S, Dewolf M, Dutilh J, Abouda M, Ferreira M, Atallah I, Lachkar S, Charriot J, Jouneau S, Uzunhan Y, Chouabe S, Coiffard B, Dutau H, Hagenburg J, Briault A, Dormoy V, Lirsac M, Vergnon JM, Deslee G, Perotin JM

BMC Pulm Med. 2022 11 17;22(1):423

The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients.

Saber Cherif L, Diabasana Z, Perotin JM, Ancel J, Petit LMG, Devilliers MA, Bonnomet A, Lalun N, Delepine G, Maskos U, Gosset P, Polette M, Muggeo A, Guillard T, Deslée G, Dormoy V

Cells. 2022 09 20;11(19):

[Nicotinic acetylcholine receptor and chronic obstructive pulmonary disease].

Dormoy V, Pons S, Gosset P, Maskos U

Med Sci (Paris). 2022 09 12;38(8-9):637-639

Editorial: and non-clinical models of kidney cancers.

Dormoy V, Filhol O, Sourbier C, Massfelder T

Front Oncol. 2022 07 26;12:987682

Whole-Exome Sequencing of Bronchial Epithelial Cells Reveals a Genetic Print of Airway Remodelling in COPD.

Germain A, Perotin JM, Delepine G, Polette M, Deslée G, Dormoy V

Biomedicines. 2022 07 15;10(7):

Preliminary results on a proposed histopathological assessment of predictive factors for basal cell carcinoma recurrence after primary free margin excision.

Jacquet A, Dormoy V, Lorenzato M, Durlach A

Skin Health Dis. 2022 06;2(2):e88

Hedgehog Signaling Pathway Orchestrates Human Lung Branching Morphogenesis.

Belgacemi R, Danopoulos S, Deutsch G, Glass I, Dormoy V, Bellusci S, Al Alam D

Int J Mol Sci. 2022 05 9;23(9):

Association between obesity-related dyspnea in daily living, lung function and body composition analyzed by DXA: a prospective study of 130 patients.

Hagenburg J, Bertin E, Salmon JH, Thierry A, Perotin JM, Dormoy V, Dury S, Gaubil I, Bolko L, Lebargy F, Deslee G, Launois C

BMC Pulm Med. 2022 Mar 25;22(1):103

Nicotinic receptors as SARS-CoV-2 spike co-receptors?

Dormoy V, Perotin JM, Gosset P, Maskos U, Polette M, Deslée G

Med Hypotheses. 2022 Jan;158:110741

Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells.

Wellemans V, Benhassou HA, Fuselier E, Bellesort F, Dury S, Lebargy F, Dormoy V, Fichel C, Naour RL, Gounni AS, Lamkhioued B

iScience. 2021 Dec 17;24(12):103433

An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions.

Routhier J, Pons S, Freidja ML, Dalstein V, Cutrona J, Jonquet A, Lalun N, Mérol JC, Lathrop M, Stitzel JA, Kervoaze G, Pichavant M, Gosset P, Tournier JM, Birembaut P, Dormoy V, Maskos U

Nat Commun. 2021 Nov 4;12(1):6384

Pulmonary cavitations with increased 18F-FDG uptake revealing a thoracic endometriosis: A case report.

Mulette P, Jacquet A, Durlach A, Papathanassiou D, Lalire P, Graesslin O, Delepine G, Dury S, Dormoy V, Perotin JM, Lebargy F, Deslée G, Launois C

Medicine (Baltimore). 2021 Oct 22;100(42):e27550

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD.

Ancel J, Belgacemi R, Diabasana Z, Perotin JM, Bonnomet A, Dewolf M, Launois C, Mulette P, Deslée G, Polette M, Dormoy V

Diagnostics (Basel). 2021 Aug 31;11(9):

Hypoxia in Lung Cancer Management: A Translational Approach.

Ancel J, Perotin JM, Dewolf M, Launois C, Mulette P, Nawrocki-Raby B, Dalstein V, Gilles C, Deslée G, Polette M, Dormoy V

Cancers (Basel). 2021 Jul 8;13(14):

Primary ciliogenesis is a crucial step for multiciliated cell determinism in the respiratory epithelium.

Belgacemi R, Diabasana Z, Hoarau A, Dubernard X, Mérol JC, Ruaux C, Polette M, Perotin JM, Deslée G, Dormoy V

J Cell Mol Med. 2021 Jun 25;:

Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia.

Diabasana Z, Perotin JM, Belgacemi R, Ancel J, Mulette P, Launois C, Delepine G, Dubernard X, Mérol JC, Ruaux C, Gosset P, Maskos U, Polette M, Deslée G, Dormoy V

Int J Mol Sci. 2021 Jun 22;22(13):

[Treatment of GERD in asthma].

Launois C, Mulette P, Ancel J, Dury S, Hagenburg J, Lebargy F, Dormoy V, Deslee G, Perotin JM

Rev Mal Respir. 2021 May 17;:

Bronchoscopic management of asthma, COPD and emphysema.

Perotin JM, Dewolf M, Launois C, Dormoy V, Deslee G

Eur Respir Rev. 2021 Mar 31;30(159):

CiliOPD: a ciliopathy-associated COPD endotype.

Perotin JM, Polette M, Deslée G, Dormoy V

Respir Res. 2021 Feb 27;22(1):74

Extended Bacteria Culture-Based Clustering Identifies a Phenotype Associating Increased Cough and in Stable Chronic Obstructive Pulmonary Disease.

Muggeo A, Perotin JM, Brisebarre A, Dury S, Dormoy V, Launois C, Ancel J, Mulette P, de Champs C, Deslée G, Guillard T

Front Microbiol. 2021 ;12:781797

ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer.

Neyrinck-Leglantier D, Lesage J, Blacher S, Bonnomet A, Hunziker W, Noël A, Dormoy V, Nawrocki-Raby B, Gilles C, Polette M

Front Cell Dev Biol. 2021 ;9:749364

Nicotinic Receptor Subunits Atlas in the Adult Human Lung.

Diabasana Z, Perotin JM, Belgacemi R, Ancel J, Mulette P, Delepine G, Gosset P, Maskos U, Polette M, Deslée G, Dormoy V

Int J Mol Sci. 2020 Oct 9;21(20):

Sonic hedgehog signalling as a potential endobronchial biomarker in COPD.

Ancel J, Belgacemi R, Perotin JM, Diabasana Z, Dury S, Dewolf M, Bonnomet A, Lalun N, Birembaut P, Polette M, Deslée G, Dormoy V

Respir. Res.. 2020 Aug 7;21(1):207

Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD.

Belgacemi R, Luczka E, Ancel J, Diabasana Z, Perotin JM, Germain A, Lalun N, Birembaut P, Dubernard X, Mérol JC, Delepine G, Polette M, Deslée G, Dormoy V

EBioMedicine. 2020 Jan;51:102572

[Obesity and asthma: Mechanisms and therapeutic options].

Guguen C, Launois C, Dormoy V, Dewolf M, Dumazet A, Dury S, Lebargy F, Deslee G, Perotin JM

Rev Mal Respir. 2019 Dec 18;:

Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions.

Fiche M, Scabia V, Aouad P, Battista L, Treboux A, Stravodimou A, Zaman K, ,Dormoy V, Ayyanan A, Sflomos G, Brisken C

J. Pathol.. 2019 03;247(3):287-292

The Lim1 oncogene as a new therapeutic target for metastatic human renal cell carcinoma.

Hamaidi I, Coquard C, Danilin S, Dormoy V, Béraud C, Rothhut S, Barthelmebs M, Benkirane-Jessel N, Lindner V, Lang H, Massfelder T

Oncogene. 2018 Aug 3;:

Alteration of primary cilia in chronic obstructive pulmonary disease.

Perotin JM, Coraux C, Lagonotte E, Birembaut P, Delepine G, Polette M, Deslée G, Dormoy V

Eur. Respir. J.. 2018 Apr 20;:

Managing patients with chronic cough: challenges and solutions.

Perotin JM, Launois C, Dewolf M, Dumazet A, Dury S, Lebargy F, Dormoy V, Deslee G

Ther Clin Risk Manag. 2018 ;14:1041-1051

A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response.

Sflomos G, Dormoy V, Metsalu T, Jeitziner R, Battista L, Scabia V, Raffoul W, Delaloye JF, Treboux A, Fiche M, Vilo J, Ayyanan A, Brisken C

Cancer Cell. 2016 Mar 14;29(3):407-422

Targeting FAK scaffold functions inhibits human renal cell carcinoma growth.

Beraud C, Dormoy V, Danilin S, Lindner V, Bethry A, Hochane M, Coquard C, Barthelmebs M, Jacqmin D, Lang H, Massfelder T

Int J Cancer. 2015 Oct 1;137(7):1549-59

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis.

Hu Z, Brooks SA, Dormoy V, Hsu CW, Hsu HY, Lin LT, Massfelder T, Rathmell WK, Xia M, Al-Mulla F, Al-Temaimi R, Amedei A, Brown DG, Prudhomme KR, Colacci A, Hamid RA, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Lowe L, Jensen L, Bisson WH, Kleinstreuer N

Carcinogenesis. 2015 Jun;36 Suppl 1:S184-202

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Goodson WH 3rd, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondracek J, Raju J, Roman J, Wise JP Sr, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engstrom W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z

Carcinogenesis. 2015 Jun;36 Suppl 1:S254-96

The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth.

Dormoy V, Danilin S, Lindner V, Thomas L, Rothhut S, Coquard C, Helwig JJ, Jacqmin D, Lang H, Massfelder T

Mol. Cancer. 2009 Dec;8:123

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