Fiche publication
Date publication
mai 2026
Journal
American journal of respiratory cell and molecular biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DORMOY Valerian
Tous les auteurs :
Massara L, Saber Cherif L, Ollivier A, Kervoaze G, Pichavant M, Dufossez C, Fawaz A, Leprêtre E, Le Rouzic O, Deslée G, Pons S, Maskos U, Dormoy V, Gosset P
Lien Pubmed
Résumé
COPD is the third leading cause of death globally. Although cigarette smoke is the dominant risk factor, only a subset of smokers develop COPD, pointing to a significant role for genetic susceptibility. The α5 nicotinic acetylcholine receptor polymorphism (α5SNP; rs16969968), is expressed in the majority of COPD patients and may modulate immune responses to cigarette smoke.
Mots clés
1. Pulmonary Disease, Chronic Obstructive/genetics, 2. Gene-Environment Interaction, 3. Receptors, Nicotinic/genetics, 4. Inflammation Mediators
Référence
Am J Respir Cell Mol Biol. 2026 05 4;:
