Dr BONNET Dominique

Fiche personne

Coordonnées

Laboratoire d'innovation thérapeutique
Faculté de pharmacie
74 route du Rhin
CS 60024
67401 ILLKIRCH Cedex

03 68 85 42 36

Territoire

Alsace

Statut

Chercheur

Affiliation

Laboratoire d'innovation thérapeutique - UMR 7200 (LIT)

Équipes/plateformes

UMR 7200 - Equipe "Chemobiologie et pharmacognosie pour la santé (CPS)"

Publications

Pharmacological inhibition of UBASH3B induces mitotic arrest and selectively reduces tumor growth.

Pangou E, Awal S, Meode M, Kleiss C, Cloarec M, Grandgirard E, Vivot K, Guerber L, Krupina K, Jerabkova-Roda K, Costa PJD, Alpy F, Martinet A, Lodi M, Cousido-Siah A, Wendling O, Hany R, Riché S, Daubeuf F, Gizzi P, Villa P, Nominé Y, Tomasetto C, Bonnet D, Sumara I

EMBO Mol Med. 2026 09 22;:

Double-Click Strategy Combining CuAAC and (Thia-) Diels-Alder Reactions; Application towards Peptide Labeling.

Maujean T, Van Wesemael C, Tual L, Le Berruyer V, Rodriguez-Noguer B, Girard N, Bonnet D, Gulea M

Chemistry. 2025 06 25;:e202501732

Click-Functionalized Cyanine Fluorogenic Dimers for Improved Detection of GPCRs: Application to imaging of ApelinR in Living Cells.

Florès O, Berthomé Y, Weiss L, Griesbaum-Dubourg S, Riché S, Wagner P, Valencia C, Villa P, Klymchenko AS, Karpenko J, Bonnet D

Chemistry. 2025 04 24;:e202500379

Flow Cytometry Analysis of Perturbations in the Bacterial Cell Envelope Enabled by Monitoring Generalized Polarization of the Solvatochromic Peptide UNR-1.

Weiss L, Bonnet D, Dziuba D, Karpenko J

Anal Chem. 2025 01 14;97(1):622-628

The metabolically resistant apelin-17 analog LIT01-196 reduces cardiac dysfunction and remodeling in heart failure after myocardial infarction.

Girault-Sotias PE, Deloux R, De Mota N, Riche S, Daubeuf F, Iturrioz X, Parlakian A, Berdeaux A, Agbulut O, Bonnet D, Boitard S, Llorens-Cortes C

Can J Cardiol. 2024 12 12;:

Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies.

Fouillen A, Couvineau P, Gaibelet G, Riché S, Orcel H, Mendre C, Kanso A, Lanotte R, Nguyen J, Dimon J, Urbach S, Sounier R, Granier S, Bonnet D, Cong X, Mouillac B, Déméné H

Comput Struct Biotechnol J. 2024 12;23:3784-3799

Fluorescent Antimicrobial Peptides Based on Nile Red: Effect of Conjugation Site and Chemistry on Wash-Free Staining of Bacteria.

Weiss L, Mirloup A, Blondé L, Manko H, Peluso J, Bonnet D, Dziuba D, Karpenko J

Bioconjug Chem. 2024 10 22;:

Acute, chronic and conditioned effects of intranasal oxytocin in the mu-opioid receptor knockout mouse model of autism: Social context matters.

Pantouli F, Pujol CN, Derieux C, Fonteneau M, Pellissier LP, Marsol C, Karpenko J, Bonnet D, Hibert M, Bailey A, Le Merrer J, Becker JAJ

Neuropsychopharmacology. 2024 07 17;:

Rational Design of Cyanine-Based Fluorogenic Dimers to Reduce Nonspecific Interactions with Albumin and Lipid Bilayers: Application to Highly Sensitive Imaging of GPCRs in Living Cells.

Berthomé Y, Gerber J, Hanser F, Riché S, Humbert N, Valencia C, Villa P, Karpenko J, Florès O, Bonnet D

Bioconjug Chem. 2024 07 9;:

Hetero-Diels-Alder and CuAAC Click Reactions for Fluorine-18 Labeling of Peptides: Automation and Comparative Study of the Two Methods.

Maujean T, Ramanoudjame SM, Riché S, Le Guen C, Boisson F, Muller S, Bonnet D, Gulea M, Marchand P

Molecules. 2024 07 5;29(13):

THE IMS LIBRARY: FROM IN-STOCK TO VIRTUAL.

Kellenberger E, Djikic-Stojsic T, Bret G, Blond G, Girard N, Le Guen C, Marsol C, Schmitt M, Schneider S, Bihel F, Bonnet D, Gulea M

ChemMedChem. 2024 06 21;:e202400381

Fluorinated apelin-13 mediates neuroprotective effects in multiple sclerosis models.

Birmpili D, Charmarké-Askar I, Spenlé C, Riché S, Pham-Van LD, Kuntzel T, Xhurxhi T, Riou A, Bonnet D, Bagnard D

Neurobiol Dis. 2024 06 4;198:106552

Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live-cell Imaging of Bioactive Peptides.

Mirloup A, Berthomé Y, Riché S, Wagner P, Hanser F, Laurent A, Iturrioz X, Llorens-Cortes C, Karpenko J, Bonnet D

Chemistry. 2024 04 20;:e202401296

Rapid and Highly Selective Fluorescent Labeling of Peptides via a Thia-Diels-Alder Cycloaddition: Application to Apelin.

Maujean T, Wagner P, Valencia C, Riché S, Iturrioz X, Villa P, Girard N, Karpenko J, Gulea M, Bonnet D

Bioconjug Chem. 2022 12 19;:

Hetero-Diels-Alder click reaction of dithioesters for a catalyst-free indirect F-radiolabelling of peptides.

Maujean T, Marchand P, Wagner P, Riché S, Boisson F, Girard N, Bonnet D, Gulea M

Chem Commun (Camb). 2022 09 15;:

Functional Rescue of a Nephrogenic Diabetes Insipidus Causing Mutation in the V2 Vasopressin Receptor by Specific Antagonist and Agonist Pharmacochaperones.

Szalai L, Sziráki A, Erdélyi LS, Kovács KB, Tóth M, Tóth AD, Turu G, Bonnet D, Mouillac B, Hunyady L, Balla A

Front Pharmacol. 2022 ;13:811836

Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor.

Hanser F, Marsol C, Valencia C, Villa P, Klymchenko AS, Bonnet D, Karpenko J

ACS Chem Biol. 2021 Mar 18;:

A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia.

Flahault A, Girault-Sotias PE, Keck M, Alvear-Perez R, De Mota N, Estéoulle L, Ramanoudjame SM, Iturrioz X, Bonnet D, Llorens-Cortes C

Nat Commun. 2021 01 12;12(1):305

A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice.

Schall N, Daubeuf F, Marsol C, Gizzi P, Frossard N, Bonnet D, Galzi JL, Muller S

Front Pharmacol. 2021 ;12:752194

LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats a NO Synthase-dependent Mechanism.

Flahault A, Keck M, Girault-Sotias PE, Esteoulle L, De Mota N, Bonnet D, Llorens-Cortes C

Front Pharmacol. 2021 ;12:715095

Three cheers for nitrogen: aza-DKPs, the aza analogues of 2,5-diketopiperazines.

Maujean T, Girard N, Ganesan A, Gulea M, Bonnet D

RSC Adv. 2020 Nov 27;10(71):43358-43370

Self-organization properties of a GPCR binding peptide incorporating fluorinated tail studied by fluorine NMR.

Jourdain de Muizon C, Ramanoudjame S, Esteoulle L, Ling C, Brou G, Anton N, Vandamme T, Delsuc MA, Bonnet D, Kieffer B

Chembiochem. 2020 Sep 28;:

A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice.

Esteoulle L, Daubeuf F, Collot M, Riché S, Durroux T, Brasse D, Marchand P, Karpenko IA, Klymchenko AS, Bonnet D

Chem Sci. 2020 Jul 14;11(26):6824-6829

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.

Fellous TG, Redpath AN, Fleischer MM, Gandhi S, Hartner SE, Newton MD, François M, Wong SP, Gowers KHC, Fahs AM, Possley DR, Bonnet D, Urquhart P, Nicolaou A, Baker KC, Rankin SM

NPJ Regen Med. 2020 Feb 21;5(1):3

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.

Fellous TG, Redpath AN, Fleischer MM, Gandhi S, Hartner SE, Newton MD, François M, Wong SP, Gowers KHC, Fahs AM, Possley DR, Bonnet D, Urquhart P, Nicolaou A, Baker KC, Rankin SM

NPJ Regen Med. 2020 ;5:3

Neutralization of CXCL12 attenuates established pulmonary hypertension in rats.

Bordenave J, Thuillet R, Tu L, Phan C, Cumont A, Marsol C, Huertas A, Savale L, Hibert M, Galzi JL, Bonnet D, Humbert M, Frossard N, Guignabert C

Cardiovasc. Res.. 2019 Jun 7;:

Chemoselective Acylation of Hydrazinopeptides to Access Fluorescent Probes for Time-Resolved FRET Assays on GPCRs.

Ramanoudjame SM, Esteoulle L, Riché S, Margathe JF, Durroux T, Karpenko IA, Bonnet D

Methods Mol. Biol.. 2019 ;1947:137-147

Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology.

Heuninck J, Hounsou C, Dupuis E, Trinquet E, Mouillac B, Pin JP, Bonnet D, Durroux T

Methods Mol. Biol.. 2019 ;1947:151-168

Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines.

Péron F, Riché S, Lesur B, Hibert M, Breton P, Fourquez JM, Girard N, Bonnet D

ACS Omega. 2018 Nov 30;3(11):15182-15192

LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.

Frantz MC, Pellissier LP, Pflimlin E, Loison S, Gandía J, Marsol C, Durroux T, Mouillac B, Becker JAJ, Le Merrer J, Valencia C, Villa P, Bonnet D, Hibert M

J. Med. Chem.. 2018 Sep 24;:

Two distinct CXCR4 antagonists mobilize progenitor cells in mice by different mechanisms.

Redpath AN, François M, Wong SP, Bonnet D, Rankin SM

Blood Adv. 2017 Oct 10;1(22):1934-1943

A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor.

Valencia C, Dujet C, Margathe JF, Iturrioz X, Roux T, Trinquet E, Villa P, Hibert M, Dupuis E, Llorens-Cortes C, Bonnet D

ChemMedChem. 2017 Apr;:

Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines.

Regenass P, Bosc D, Riché S, Gizzi P, Hibert M, Karmazin L, Ganesan A, Bonnet D

J. Org. Chem.. 2017 Mar;82(6):3239-3244

Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects.

Gerbier R, Alvear-Perez R, Margathe JF, Flahault A, Couvineau P, Gao J, De Mota N, Dabire H, Li B, Ceraudo E, Hus-Citharel A, Esteoulle L, Bisoo C, Hibert M, Berdeaux A, Iturrioz X, Bonnet D, Llorens-Cortes C

FASEB J.. 2017 Feb;31(2):687-700

Decreased Migration of Dendritic Cells into the Jugular-Nodose Ganglia by the CXCL12 Neutraligand Chalcone 4 in Ovalbumin-Sensitized Asthmatic Mice.

Heck S, Daubeuf F, Le DD, Sester M, Bonnet D, Bals R, Frossard N, Dinh QT

Neuroimmunomodulation. 2017 ;24(6):331-340

A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis.

Regenass P, Riché S, Péron F, Rognan D, Hibert M, Girard N, Bonnet D

Org. Biomol. Chem.. 2016 Sep;14(37):8859-8863

Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions.

Karpenko IA, Niko Y, Yakubovskyi VP, Gerasov AO, Bonnet D, Kovtun YP, Klymchenko AS

J Mater Chem C Mater. 2016 Apr 14;4(14):3002-3009

Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

Margathe JF, Iturrioz X, Regenass P, Karpenko IA, Humbert N, de Rocquigny H, Hibert M, Llorens-Cortes C, Bonnet D

Chemistry. 2016 Jan;22(4):1399-405

Increasing cellular immunogenicity to peptide-based vaccine candidates using a fluorocarbon antigen delivery system.

Francis JN, Thaburet JF, Bonnet D, Sizer PJ, Brown CB, Georges B

Vaccine. 2015 Feb 18;33(8):1071-6

Small neutralizing molecules to inhibit actions of the chemokine CXCL12.

Hachet-Haas M, Balabanian K, Rohmer F, Pons F, Franchet C, Lecat S, Chow KY, Dagher R, Gizzi P, Didier B, Lagane B, Kellenberger E, Bonnet D, Baleux F, Haiech J, Parmentier M, Frossard N, Arenzana-Seisdedos F, Hibert M, Galzi JL

J Biol Chem. 2008 Aug 22;283(34):23189-99

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