Mercier C, Baudin M, Fiorini F, Hognon C, Durand J, Perez V, Peigney A, Lebars I, Hervouet É, Peixoto P, Delage-Mourroux R, Fraichard A, Guittaut M, Baguet A

J Mol Biol. 2026 05 8;:169847

GABARAPL1 is important for the activation of HRI during eIF2α phosphorylation-dependent stress response to sodium arsenite.

Campenet S, Lamarre M, Durand J, Perez V, Peixoto P, Delage-Mourroux R, Guittaut M, Baguet A, Despouy G

Sci Rep. 2026 03 28;:

Dynamic DNA methylation changes during colorectal oncogenesis with insights from adenoma stages.

Overs A, Molimard C, Durand J, Bibeau F, Arnould L, Monnien F, Clavier C, Borg C, Guittaut M, Feugeas JP, Hervouet E, Peixoto P, Selmani Z

Sci Rep. 2025 11 25;:

The Years 2015-2025 as a Prospective Decade for the Identification of Specific Methylation Biomarkers of Prostate Cancer.

Selmani Z, Peixoto P, Overs A, Hervouet E

Biomolecules. 2025 09 18;15(9):

Beneficial effect of resveratrol on T cell oxidative metabolism and anti-tumor function is conditioned by prior T cell history.

Mercier-Letondal P, Marton C, Royer B, Peixoto P, Dehecq B, Adotévi O, Galaine J, Godet Y

Mol Ther Methods Clin Dev. 2025 09 11;33(3):101553

Fever-range temperature alters continual efferocytosis mediated by mouse pro-inflammatory macrophages.

Vetter M, Maraux M, Bonnefoy F, Dal Zuffo L, Lamarthée B, Rolin G, Wetzel A, Perruche S, Peixoto P, Saas P

J Leukoc Biol. 2025 05 14;:

Chemical inhibition of eIF4A3 abolishes UPF1 recruitment onto mRNA encoding NMD factors and restores their expression.

Mercier C, Durand J, Fraichard A, Perez V, Hervouet E, Peixoto P, Delage-Mourroux R, Guittaut M, Baguet A

Biochem Biophys Res Commun. 2024 12 30;747:151270

COL25A1 and METAP1D DNA methylation are promising liquid biopsy epigenetic biomarkers of colorectal cancer using digital PCR.

Overs A, Peixoto P, Hervouet E, Molimard C, Monnien F, Durand J, Guittaut M, Vienot A, Viot J, Herfs M, Borg C, Feugeas JP, Selmani Z

Clin Epigenetics. 2024 10 18;16(1):146

Distinct regulation of EZH2 and its repressive H3K27me3 mark in Polyomavirus -positive and -negative Merkel cell carcinoma.

Durand MA, Drouin A, Mouchard A, Durand L, Esnault C, Berthon P, Tallet A, Le Corre Y, Hainaut-Wierzbicka E, Blom A, Saiag P, Beneton N, Bens G, Nardin C, Aubin F, Dinulescu M, Collin C, Fromont-Hankard G, Cribier B, Laurent-Roussel S, Cokelaere K, Houben R, Schrama D, Peixoto P, Hervouet E, Bachiri K, Kantar D, Coyaud E, Guyétant S, Samimi M, Touzé A, Kervarrec T

J Invest Dermatol. 2023 04 8;:

CD8 CD226 T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery.

Viot J, Abdeljaoued S, Vienot A, Seffar E, Spehner L, Bouard A, Asgarov K, Pallandre JR, Renaude E, Klajer E, Molimard C, Monnien F, Bibeau F, Turco C, Heyd B, Peixoto P, Hervouet E, Loyon R, Doussot A, Borg C, Kroemer M

Cell Mol Immunol. 2023 01 30;:

SALL4-related gene signature defines a specific stromal subset of pancreatic ductal adenocarcinoma with poor prognostic features.

Vienot A, Monnien F, Truntzer C, Mougey V, Bouard A, Pallandre JR, Molimard C, Loyon R, Asgarov K, Averous G, Ghiringhelli F, Bibeau F, Peixoto P, Borg C

Mol Oncol. 2023 01 1;:

Chemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapy.

Vienot A, Pallandre JR, Renaude E, Viot J, Bouard A, Spehner L, Kroemer M, Abdeljaoued S, van der Woning B, de Haard H, Loyon R, Hervouet E, Peixoto P, Borg C

Oncoimmunology. 2022 11 12;11(1):2144669

High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression.

Poirson J, Suarez IP, Straub ML, Cousido-Siah A, Peixoto P, Hervouet E, Foster A, Mitschler A, Mukobo N, Chebaro Y, Garcin D, Recberlik S, Gaiddon C, Altschuh D, Nominé Y, Podjarny A, Trave G, Masson M

J Virol. 2022 Apr 27;:e0187521

HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources.

Lebeau A, Bruyere D, Roncarati P, Peixoto P, Hervouet E, Cobraiville G, Taminiau B, Masson M, Gallego C, Mazzucchelli G, Smargiasso N, Fleron M, Baiwir D, Hendrick E, Pilard C, Lerho T, Reynders C, Ancion M, Greimers R, Twizere JC, Daube G, Schlecht-Louf G, Bachelerie F, Combes JD, Melin P, Fillet M, Delvenne P, Hubert P, Herfs M

Nat Commun. 2022 Feb 28;13(1):1076

Proximity Ligation in Situ Assay to Monitor Autophagy-Related Protein Interactions and Autophagy in Cancer Cells.

Peixoto P, Guittaut M, Hervouet E

Methods Mol Biol. 2022 ;2543:167-178

DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity.

Duchemin A, O'Grady T, Hanache S, Mereau A, Thiry M, Wacheul L, Michaux C, Perpète E, Hervouet E, Peixoto P, Ernst FGM, Audic Y, Dequiedt F, Lafontaine DLJ, Mottet D

Nat Commun. 2021 Nov 17;12(1):6648

The NMD Pathway Regulates mRNA during the EMT.

Baudu T, Parratte C, Perez V, Ancion M, Millevoi S, Hervouet E, Peigney A, Peixoto P, Overs A, Herfs M, Fraichard A, Guittaut M, Baguet A

Biomedicines. 2021 Sep 23;9(10):

Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers.

Lachat C, Peixoto P, Hervouet E

Biomolecules. 2021 May 22;11(6):

SLFN5 regulates LAT1-mediated mTOR activation in castration-resistant prostate cancer.

Martinez RS, Salji MJ, Rushworth L, Ntala C, Rodriguez Blanco G, Hedley A, Clark W, Peixoto P, Hervouet E, Renaude E, Kung SHY, Galbraith LCA, Nixon C, Lilla S, Mackay GM, Fazli L, Gaughan L, Sumpton D, Gleave ME, Zanivan S, Blomme A, Leung HY

Cancer Res. 2021 May 13;:

The tumor microenvironment impairs Th1 IFNγ secretion through alternative splicing modifications of Irf1 pre-mRNA.

Bernard A, Hibos C, Richard C, Viltard E, Chevrier S, Lemoine S, Melin J, Humblin E, Mary R, Accogli T, Chalmin F, Bruchard M, Peixoto P, Hervouet E, Apetoh L, Ghiringhelli F, Vegran F, Boidot R

Cancer Immunol Res. 2021 Jan 8;:

Epigenetic Reprogramming of CD4 Helper T Cells as a Strategy to Improve Anticancer Immunotherapy.

Renaude E, Kroemer M, Borg C, Peixoto P, Hervouet E, Loyon R, Adotévi O

Front Immunol. 2021 ;12:669992

Autophagy is associated with a robust specific transcriptional signature in breast cancer subtypes.

Grandvallet C, Feugeas JP, Monnien F, Despouy G, Valérie P, Michaël G, Hervouet E, Peixoto P

Genes Cancer. 2020 Dec 31;11(3-4):154-168

EZH2 and KDM6B Expressions Are Associated with Specific Epigenetic Signatures during EMT in Non Small Cell Lung Carcinomas.

Lachat C, Bruyère D, Etcheverry A, Aubry M, Mosser J, Warda W, Herfs M, Hendrick E, Ferrand C, Borg C, Delage-Mourroux R, Feugeas JP, Guittaut M, Hervouet E, Peixoto P

Cancers (Basel). 2020 Dec 5;12(12):

From 1957 to Nowadays: A Brief History of Epigenetics.

Peixoto P, Cartron PF, Serandour AA, Hervouet E

Int J Mol Sci. 2020 Oct 14;21(20):

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.

Blomme A, Ford CA, Mui E, Patel R, Ntala C, Jamieson LE, Planque M, McGregor GH, Peixoto P, Hervouet E, Nixon C, Salji M, Gaughan L, Markert E, Repiscak P, Sumpton D, Blanco GR, Lilla S, Kamphorst JJ, Graham D, Faulds K, MacKay GM, Fendt SM, Zanivan S, Leung HY

Nat Commun. 2020 May 19;11(1):2508

The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment.

Renaude E, Kroemer M, Loyon R, Binda D, Borg C, Guittaut M, Hervouet E, Peixoto P

Int J Mol Sci. 2020 Feb 29;21(5):

Epigenetic Control of Autophagy in Cancer Cells: A Key Process for Cancer-Related Phenotypes.

Peixoto P, Grandvallet C, Feugeas JP, Guittaut M, Hervouet E

Cells. 2019 Dec 17;8(12):

EMT is associated with an epigenetic signature of ECM remodeling genes.

Peixoto P, Etcheverry A, Aubry M, Missey A, Lachat C, Perrard J, Hendrick E, Delage-Mourroux R, Mosser J, Borg C, Feugeas JP, Herfs M, Boyer-Guittaut M, Hervouet E

Cell Death Dis. 2019 Feb 27;10(3):205

Epigenetic Regulation of EMT (Epithelial to Mesenchymal Transition) and Tumor Aggressiveness: A View on Paradoxical Roles of KDM6B and EZH2.

Lachat C, Boyer-Guittaut M, Peixoto P, Hervouet E

Epigenomes. 2018 Dec 20;3(1):

Is Overexpressed in Triple Negative Breast Cancer and Its In Vitro Extinction Leads to the Inhibition of Pro-Cancer Phenotypes.

Claude-Taupin A, Fonderflick L, Gauthier T, Mansi L, Pallandre JR, Borg C, Perez V, Monnien F, Algros MP, Vigneron M, Adami P, Delage-Mourroux R, Peixoto P, Herfs M, Boyer-Guittaut M, Hervouet E

Cells. 2018 Dec 6;7(12):

Circulating cell-free DNA in patients with alveolar echinococcosis.

Baraquin A, Hervouet E, Richou C, Flori P, Peixoto P, Azizi A, Delabrousse E, Blagosklonov O, Umhang G, Bresson-Hadni S, Valot B, Grenouillet F,

Mol. Biochem. Parasitol.. 2018 Apr 18;222:14-20

PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma.

Asgarova A, Asgarov K, Godet Y, Peixoto P, Nadaradjane A, Boyer-Guittaut M, Galaine J, Guenat D, Mougey V, Perrard J, Pallandre JR, Bouard A, Balland J, Tirole C, Adotevi O, Hendrick E, Herfs M, Cartron PF, Borg C, Hervouet E

Oncoimmunology. 2018 ;7(5):e1423170

Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma.

Hervouet E, Peixoto P, Delage-Mourroux R, Boyer-Guittaut M, Cartron PF

Clin Epigenetics. 2018 ;10:17

New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity.

Henry A, Nokin MJ, Leroi N, Lallemand F, Lambert J, Goffart N, Roncarati P, Bianchi E, Peixoto P, Blomme A, Turtoi A, Peulen O, Habraken Y, Scholtes F, Martinive P, Delvenne P, Rogister B, Castronovo V, Bellahcène A

Oncotarget. 2016 Sep;7(39):63708-63721

HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies.

Peixoto P, Blomme A, Costanza B, Ronca R, Rezzola S, Palacios AP, Schoysman L, Boutry S, Goffart N, Peulen O, Maris P, Di Valentin E, Hennequière V, Bianchi E, Henry A, Meunier P, Rogister B, Muller RN, Delvenne P, Bellahcène A, Castronovo V, Turtoi A

Oncogene. 2016 Aug;35(34):4481-94

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