Pr ORTEGA DEBALLON Pablo

Value of the feces sign in predicting successful conservative management of adhesive small bowel obstruction: A retrospective cohort study.

Guiraud A, Vadot V, Fournel I, Loffroy R, Gozalichvili D, Ortega-Deballon P

Curr Probl Surg. 2026 05;78:102022

Future impacts of colectomy healthcare pathways on quality of care in bundled payment experiments, a national retrospective cohort in France.

Sanchez MA, Mercier G, Clément MC, Ortega-Deballon P, Sanchez S, Quantin C

PLoS One. 2026 04 9;21(4):e0346558

Long-Term Outcomes After Slowly Resorbable P4HB Mesh Implantation: A Multicenter Analysis From European Registry.

van den Berg R, Wieser M, López-Cano M, Bueno-Lledó J, Köckerling F, Chatzimavroudis G, Gonella-Pacchiotti C, Stabilini C, Ortega-Deballon P, Romain B,

World J Surg. 2026 03 20;:

French nationwide monthly online consultation meeting on complex abdominal wall repairs: 4-year assessment of an innovative collaborative decision-making tool.

Joliat GR, Gillion JF, Baud G, Romain B, Renard Y, Ortega-Deballon P, Dubuisson V, Khalil H, Moszkowicz D, Passot G,

Hernia. 2025 10 9;29(1):288

Postoperative respiratory morbidity in chronic obstructive pulmonary disease patients receiving botulinum toxin injection before abdominal wall surgery: A multicentric study.

Joliat GR, Ortega-Deballon P, Alsuwaidan H, Moszkowicz D, Romain B, Renard Y, Passot G

Surgery. 2025 09 30;188:109765

High-density lipoproteins alleviate the endotoxin burden in patients with peritonitis and sepsis: The LIPS study.

Nguyen M, Alvarez M, Berthoud V, Pallot G, Abagri S, Leleu D, Pais-De-Barros JP, Ortega-Deballon P, Guinot PG, Masson D, Gautier T, Bouhemad B

Eur J Clin Invest. 2025 07 19;:e70099

Hartmann's procedure versus primary anastomosis for Hinchey III or IV sigmoid diverticulitis: a propensity score analysis of a retrospective national cohort study.

Pellegrin A, Alves A, Beyer-Berjot L, Zerbib P, Bridoux V, Manceau G, Panis Y, Buscail E, Venara A, Khaoudy I, Gaillard M, Ortega-Deballon P, Thobie A, Menahem B, Eveno C, Bonnel C, Mabrut JY, Badic B, Godet C, Eid Y, Duchalais E, Lakkis Z, Cotte E, Laforest A, Desfourneaux V, Maggiori L, Rebibo L, Niki C, Talal A, Mege D, Bonnamy C, Germain A, Mauvais F, Tresallet C, Roudie J, Laurent A, Trilling B, Martin B, Massalou D, Romain B, Tranchart H, Giger U, Ouaissi M, Briant AR, Parienti JJ, Sabbagh C

Surg Endosc. 2025 07 14;:

Does sarcopenia have a negative impact on the efficacy of botulinum toxin A in the prehabilitation of patients undergoing incisional hernia repair? A multicentric retrospective study.

Villemin A, Delorme T, Ortega-Deballon P, Alsuwaidan H, Moszkowicz D, Romain B

Hernia. 2025 02 18;29(1):104

External validation of a CT score for predicting ischaemia in adhesive small-bowel obstruction.

Vadot V, Guiraud A, Kalilou Sow A, Fournel I, Simon G, Acquier A, Mvouama S, Chevallier O, Ortega-Deballon P, Loffroy R

Eur Radiol. 2025 01 24;:

Parastomal hernia after ileal conduit: Incidence, natural history and risk factors.

Blanc PY, Fournel I, Bel N, Delchet O, Belloni E, Renard Y, Moszkowicz D, Romain B, Passot G, Ortega-Deballon P,

World J Surg. 2024 09 14;:

Diagnostic Accuracy of Lipase as Early Predictor of Postoperative Pancreatic Fistula: Results from the LIPADRAIN study.

Doussot B, Doussot A, Ayav A, Santucci N, Deguelte S, Sow AK, El Amrani M, Duvillard L, Piessen G, Girard E, Mabrut JY, Garnier J, Ortega-Deballon P, Fournel I, Facy O

Ann Surg Open. 2024 09;5(3):e492

Management of patients with high C-reactive protein levels after elective colorectal surgery: Pilot study on a proactive diagnostic and therapeutic approach (GESPACE).

Gozalichvili D, Fournel I, Sow AK, Guiraud A, Moreno-Lopez N, Orry D, Facy O, Ortega-Deballon P

J Visc Surg. 2024 06 21;:

Risk factors for severe morbidity and definitive stoma after elective surgery for sigmoid diverticulitis: a multicenter national cohort study.

Sabbagh C, Beyer-Berjot L, Ouaissi M, Zerbib P, Bridoux V, Manceau G, Karoui M, Panis Y, Buscail E, Venara A, Khaoudy I, Gaillard M, Ortega-Deballon P, Viennet M, Thobie A, Menahem B, Eveno C, Bonnel C, Mabrut JY, Badic B, Godet C, Eid Y, Duchalais E, Lakkis Z, Cotte E, Laforest A, Defourneaux V, Maggiorri L, Rebibo L, Christou N, Talal A, Mege D, Bonnamy C, Germain A, Mauvais F, Tresallet C, Ahmed O, Regimbeau JM, Roudie J, Laurent A, Trilling B, Bertrand M, Massalou D, Romain B, Tranchart H, Giger U, Dejardin O, Pellegrin A, Alves A,

Tech Coloproctol. 2024 02 19;28(1):34

Association between polyunsaturated fatty acids in adipose tissue and mortality of colorectal cancer patients.

Roux-Levy C, Binquet C, Vaysse C, Scherrer ML, Ayav A, Ortega-Deballon P, Lakkis Z, Liu D, Deguelte S, Cottet V

Nutrition. 2024 01 10;121:112358

Does intraperitoneal mesh increase the risk of bowel obstruction? A nationwide French analysis.

Delorme T, Cottenet J, Abo-Alhassan F, Bernard A, Ortega-Deballon P, Quantin C

Hernia. 2023 09 28;:

Increased risk of colon cancer after acute appendicitis: a nationwide, population-based study.

Viennet M, Tapia S, Cottenet J, Bernard A, Ortega-Deballon P, Quantin C

EClinicalMedicine. 2023 09;63:102196

Surgical management of parastomal hernia following radical cystectomy and ileal conduit: A french multi-institutional experience.

Bel N, Blanc PY, Moszkowicz D, Kim B, Deballon PO, Berrada D, Liu D, Romain B, Ophélie D, Renard Y, Passot G,

Langenbecks Arch Surg. 2023 08 29;408(1):344

Impact of hospital volume in liver surgery on postoperative mortality and morbidity: nationwide study.

Magnin J, Bernard A, Cottenet J, Lequeu JB, Ortega-Deballon P, Quantin C, Facy O

Br J Surg. 2023 02 2;:

Early detection of anastomotic leakage with C-reactive protein increases the chances of anastomotic salvage.

Gozalichvili D, Binquet C, Boisson C, Guiraud A, Facy O, Ortega-Deballon P

Colorectal Dis. 2022 11 2;:

C-reactive protein identifies patients at low risk of anastomotic leak after esophagectomy.

Rat P, Piessen G, Vanderbeken M, Chebaro A, Facy O, Rat P, Boisson C, Ortega-Deballon P

Langenbecks Arch Surg. 2022 10 8;:

Benefit of a flash dose of corticosteroids in digestive surgical oncology: a multicenter, randomized, double blind, placebo-controlled trial (CORTIFRENCH).

Magnin J, Fournel I, Doussot A, Régimbeau JM, Zerbib P, Piessen G, Beyer-Berjot L, Deguelte S, Lakkis Z, Schwarz L, Orry D, Ayav A, Muscari F, Mauvais F, Passot G, Trelles N, Venara A, Benoist S, Messager M, Fuks D, Borraccino B, Trésallet C, Valverde A, Souche FR, Herrero A, Gaujoux S, Lefevre J, Bourredjem A, Cransac A, Ortega-Deballon P

BMC Cancer. 2022 08 23;22(1):913

Accidental ingestion of hydrogen peroxide.

Caillot J, Grellet R, Robelin F, Rat P, Ortega Deballon P

Surgery. 2022 05 25;:

Incisional hernia repair with a slowly absorbable P4HB mesh: what happens after the mesh disappears? A retrospective longitudinal clinical study.

Layer T, Benammi S, Dubuisson V, Manfredelli S, Passot G, Charleux-Muller D, Renard Y, Ortega-Deballon P, Romain B

Hernia. 2022 May 10;:

Lipidomic profiling of exosomes from colorectal cancer cells and patients reveals potential biomarkers.

Elmallah MIY, Ortega-Deballon P, Hermite L, Pais-De-Barros JP, Gobbo J, Garrido C

Mol Oncol. 2022 May 6;:

Longitudinal cohort study on preoperative pain as a risk factor for chronic postoperative inguinal pain after groin hernia repair at 2-year follow-up.

Romain B, Fabacher T, Ortega-Deballon P, Montana L, Cossa JP, Gillion JF,

Hernia. 2021 Apr 23;:

Lactobacillus stress protein GroEL prevents colonic inflammation.

Dias AMM, Douhard R, Hermetet F, Regimbeau M, Lopez TE, Gonzalez D, Masson S, Marcion G, Chaumonnot K, Uyanik B, Causse SZ, Rieu A, Hadi T, Basset C, Chluba J, Grober J, Guzzo J, Neiers F, Ortega-Deballon P, Demidov ON, Lirussi F, Garrido C

J Gastroenterol. 2021 Mar 29;:

Slowly absorbable mesh in contaminated incisional hernia repair: results of a French multicenter study.

Charleux-Muller D, Hurel R, Fabacher T, Brigand C, Rohr S, Manfredelli S, Passot G, Ortega-Deballon P, Dubuisson V, Renard Y, Romain B

Hernia. 2021 Jan 25;:

What results can be expected one year after complex incisional hernia repair with biosynthetic mesh?

Vauclair E, Bert M, Facy O, Cheynel N, Rat P, Ortega-Deballon P

J Visc Surg. 2021 Jan 13;:

Preoperative inflammation is an independent factor of worse prognosis after colorectal cancer surgery.

Bert M, Devilliers H, Orry D, Rat P, Facy O, Ortega-Deballon P

J Visc Surg. 2021 Jan 11;:

Endocannabinoids Produced by White Adipose Tissue Modulate Lipolysis in Lean but Not in Obese Rodent and Human.

Buch C, Muller T, Leemput J, Passilly-Degrace P, Ortega-Deballon P, Pais de Barros JP, Vergès B, Jourdan T, Demizieux L, Degrace P

Front Endocrinol (Lausanne). 2021 ;12:716431

Inflammatory markers for the early detection of post-operative infection: The same threshold for rectal and colic surgery?

Vauclair E, Moreno-Lopez N, Orry D, Fournel I, Rat P, Ortega-Deballon P, Facy O

J Visc Surg. 2020 Nov 9;:

Is Lanreotide Really Useful in High Output Stoma? Comparison between Lanreotide to Conventional Antidiarrheal Treatment Alone.

Mesli Y, Holterbach L, Delhorme JB, Lakkis Z, Ortega-Deballon P, Deguelte S, Rohr S, Brigand C, Meyer N, Romain B

J Invest Surg. 2020 Aug 4;:1-5

Enteral versus parenteral nutrition in the conservative treatment of upper gastrointestinal fistula after surgery: a multicenter, randomized, parallel-group, open-label, phase III study (NUTRILEAK study).

Gronnier C, Chambrier C, Duhamel A, Dervaux B, Collet D, Vaudoyer D, Régimbeau JM, Jougon J, Théréaux J, Lebreton G, Veziant J, Valverde A, Ortega-Deballon P, Pattou F, Mathonnet M, Perinel J, Beyer-Berjot L, Fuks D, Rouanet P, Lefevre JH, Cattan P, Deguelte S, Meunier B, Tuech JJ, Pessaux P, Carrere N, Salame E, Benaim E, Dousset B, Msika S, Mariette C, Piessen G,

Trials. 2020 Jun 2;21(1):448

Recurrence after elective incisional hernia repair is more frequent than you think: An international prospective cohort from the French Society of Surgery.

Romain B, Renard Y, Binquet C, Poghosyan T, Moszkowicz D, Gillion JF, Ortega-Deballon P,

Surgery. 2020 Apr 15;:

Simultaneous Versus Delayed Resection for Initially Resectable Synchronous Colorectal Cancer Liver Metastases: A Prospective, Open-label, Randomized, Controlled Trial.

Boudjema K, Locher C, Sabbagh C, Ortega-Deballon P, Heyd B, Bachellier P, Métairie S, Paye F, Bourlier P, Adam R, Merdrignac A, Tual C, Le Pabic E, Sulpice L, Meunier B, Regimbeau JM, Bellissant E,

Ann. Surg.. 2020 Mar 20;:

CHIPOFIL: A pilot study assessing the feasibility of HIPEC without extracorporeal circuit.

Ortega-Deballon P, Facy O, Binquet C, Delroeux D, Rat P

Pleura Peritoneum. 2019 Sep 1;4(3):20190008

Pancreatic ductal adenocarcinoma and paraaortic lymph nodes metastases: The accuracy of intraoperative frozen section.

Doussot A, Bouvier A, Santucci N, Lequeu JB, Cheynel N, Ortega-Deballon P, Rat P, Facy O

Pancreatology. 2019 May 31;:

Indications and Outcomes of a Cross-Linked Porcine Dermal Collagen Mesh (Permacol) for Complex Abdominal Wall Reconstruction: A Multicenter Audit.

Doussot A, Abo-Alhassan F, Derbal S, Fournel I, Kasereka-Kisenge F, Codjia T, Khalil H, Dubuisson V, Najah H, Laurent A, Romain B, Barrat C, Trésallet C, Mathonnet M, Ortega-Deballon P

World J Surg. 2018 Nov 13;:

CA 19-9 predicts resectability of pancreatic cancer even in jaundiced patients.

Santucci N, Facy O, Ortega-Deballon P, Lequeu JB, Rat P, Rat P

Pancreatology. 2018 Sep;18(6):666-670

Altered distribution and function of splenic innate lymphoid cells in adult chronic immune thrombocytopenia.

Audia S, Moulinet T, Ciudad-Bonté M, Samson M, Facy O, Ortega-Deballon P, Saas P, Bonnotte B

J. Autoimmun.. 2018 Jul 23;:

Patient's satisfaction at 2 years after groin hernia repair: any difference according to the technique?

Romain B, Gillion JF, Ortega-Deballon P, Meyer N,

Hernia. 2018 Jul 3;:

Intraperitoneal drains move.

Gilbert A, Ortega-Deballon P, Di Giacomo G, Cheynel N, Rat P, Facy O

J Visc Surg. 2018 Apr;155(2):105-110

Inflammatory markers as early predictors of infection after colorectal surgery: the same cut-off values in laparoscopy and laparotomy?

Facy O, Paquette B, Orry D, Santucci N, Rat P, Rat P, Binquet C, Ortega-Deballon P

Int J Colorectal Dis. 2017 Apr;:

B cell depleting therapy regulates splenic and circulating T follicular helper cells in immune thrombocytopenia.

Audia S, Rossato M, Trad M, Samson M, Santegoets K, Gautheron A, Bekker C, Facy O, Cheynel N, Ortega-Deballon P, Boulin M, Berthier S, Leguy-Seguin V, Martin L, Ciudad M, Janikashvili N, Saas P, Radstake T, Bonnotte B

J. Autoimmun.. 2017 Feb;77:89-95

Should CT scan be performed when CRP is elevated after colorectal surgery? Results from the inflammatory markers after colorectal surgery study.

Holl S, Fournel I, Orry D, Facy O, Cheynel N, Rat P, Ortega-Deballon P

J Visc Surg. 2017 Feb;154(1):5-9

Fcγ receptor expression on splenic macrophages in adult immune thrombocytopenia.

Audia S, Santegoets K, Laarhoven AG, Vidarsson G, Facy O, Ortega-Deballon P, Samson M, Janikashvili N, Saas P, Bonnotte B, Radstake TR

Clin. Exp. Immunol.. 2017 Jan;:

Robot-Assisted Choledochoduodenostomy: A Safe and Reproducible Procedure for Benign Common Bile Duct Obstruction.

Gilbert A, Doussot A, Ortega-Deballon P, Rostain F, Rat P, Facy O

Dig Surg. 2017 Jan;:

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis in the Elderly: A Case-Controlled, Multicenter Study.

Alyami M, Lundberg P, Kepenekian V, Goéré D, Bereder JM, Msika S, Lorimier G, Quenet F, Ferron G, Thibaudeau E, Abboud K, Lo Dico R, Delroeux D, Brigand C, Arvieux C, Marchal F, Tuech JJ, Guilloit JM, Guyon F, Peyrat P, Pezet D, Ortega-Deballon P, Zinzindohoue F, de Chaisemartin C, Kianmanesh R, Glehen O, Passot G,

Ann. Surg. Oncol.. 2016 Dec;23(Suppl 5):737-745

Diffuse malignant peritoneal mesothelioma: Evaluation of systemic chemotherapy with comprehensive treatment through the RENAPE Database: Multi-Institutional Retrospective Study.

Kepenekian V, Elias D, Passot G, Mery E, Goere D, Delroeux D, Quenet F, Ferron G, Pezet D, Guilloit JM, Meeus P, Pocard M, Bereder JM, Abboud K, Arvieux C, Brigand C, Marchal F, Classe JM, Lorimier G, De Chaisemartin C, Guyon F, Mariani P, Ortega-Deballon P, Isaac S, Maurice C, Gilly FN, Glehen O,

Eur. J. Cancer. 2016 Sep;65:69-79

Preoperative inflammation increases the risk of infection after elective colorectal surgery: results from a prospective cohort.

De Magistris L, Paquette B, Orry D, Facy O, Di Giacomo G, Rat P, Binquet C, Ortega-Deballon P

Int J Colorectal Dis. 2016 Sep;31(9):1611-7

Diagnostic Accuracy of Procalcitonin and C-reactive Protein for the Early Diagnosis of Intra-abdominal Infection After Elective Colorectal Surgery: A Meta-analysis.

Cousin F, Ortega-Deballon P, Bourredjem A, Doussot A, Giaccaglia V, Fournel I

Ann. Surg.. 2016 Aug;264(2):252-6

Abdominal tuberculosis in a low prevalence country.

Fillion A, Ortega-Deballon P, Al-Samman S, Briault A, Brigand C, Deguelte S, Germain A, Hansmann Y, Pelascini E, Rabaud C, Chavanet P, Piroth L

Med Mal Infect. 2016 May;46(3):140-5

Diagnostic Accuracy of Inflammatory Markers As Early Predictors of Infection After Elective Colorectal Surgery: Results From the IMACORS Study.

Facy O, Paquette B, Orry D, Binquet C, Masson D, Bouvier A, Fournel I, Charles PE, Rat P, Ortega-Deballon P

Ann Surg. 2015 Jul 1.

Professional risks when carrying out cytoreductive surgery for peritoneal malignancy with hyperthermic intraperitoneal chemotherapy (HIPEC): A French multicentric survey.

Ferron G, Simon L, Guyon F, Glehen O, Goere D, Elias D, Pocard M, Gladieff L, Bereder JM, Brigand C, Classe JM, Guilloit JM, Quenet F, Abboud K, Arvieux C, Bibeau F, De Chaisemartin C, Delroeux D, Durand-Fontanier S, Goasguen N, Gouthi L, Heyd B, Kianmanesh R, Leblanc E, Loi V, Lorimier G, Marchal F, Mariani P, Mariette C, Meeus P, Msika S, Ortega-Deballon P, Paineau J, Pezet D, Piessen G, Pirro N, Pomel C, Porcheron J, Pourcher G, Rat P, Regimbeau JM, Sabbagh C, Thibaudeau E, Torrent JJ, Tougeron D, Tuech JJ, Zinzindohoue F, Lundberg P, Herin F, Villeneuve L

Eur J Surg Oncol. 2015 Jul 29. pii: S0748-7983(15)00555-7

Are Adiponectin and Leptin Good Predictors of Surgical Infection after Colorectal Surgery? A Prospective Study.

Ortega-Deballon P, Menegaut L, Fournel I, Orry D, Masson D, Binquet C, Facy O

Surg Infect (Larchmt). 2015 Jun 26.

C-reactive protein to rule out infections after major abdominal surgery.

Ortega-Deballon P, Facy O, Rat P

Int J Colorectal Dis. 2015 Jun 14.

Stump closure reinforcement with absorbable fibrin collagen sealant sponge (TachoSil) does not prevent pancreatic fistula after distal pancreatectomy: the FIABLE multicenter controlled randomized study.

Sa Cunha A, Carrere N, Meunier B, Fabre JM, Sauvanet A, Pessaux P, Ortega-Deballon P, Fingerhut A, Lacaine F

Am J Surg. 2015 Jun 11. pii: S0002-9610(15)00333-5

The short- and long-term outcomes of pancreaticoduodenectomy for cancer in Child A patients are acceptable: a patient-control study from the Surgical French Association report for pancreatic surgery.

Regimbeau JM, Rebibo L, Dokmak S, Boher JM, Sauvanet A, Chopin-Laly X, Adham M, Lesurtel M, Bigourdan JM, Truant S, Pruvot FR, Ortega-Deballon P, Paye F, Bachellier P, Delpero JR

J Surg Oncol. 2015 May;111(6):776-83

Fatty acid composition of adipose tissue and colorectal cancer: a case-control study.

Cottet V, Vaysse C, Scherrer ML, Ortega-Deballon P, Lakkis Z, Delhorme JB, Deguelte-Lardiere S, Combe N, Bonithon-Kopp C

Am J Clin Nutr. 2015 Jan;101(1):192-201

High pressure does not counterbalance the advantages of open techniques over closed techniques during heated intraperitoneal chemotherapy with oxaliplatin.

Facy O, Combier C, Poussier M, Magnin G, Ladoire S, Ghiringhelli F, Chauffert B, Rat P, Ortega-Deballon P

Surgery. 2015 Jan;157(1):72-8

Incidence and survival in late liver metastases of colorectal cancer.

Landreau P, Drouillard A, Launoy G, Ortega-Deballon P, Jooste V, Lepage C, Faivre J, Facy O, Bouvier AM

J. Gastroenterol. Hepatol.. 2015 Jan;30(1):82-5

Indications for anti-reflux surgery in Barrett's esophagus.

Ortega Deballon P

Cir Esp. 2015 Jan 20. pii: S0009-739X(14)00379-0

Perioperative immunonutrition.

Ortega Deballon P, Pieri DE, Verret S

Cir Esp. 2014 Dec;92(10):701-2

Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia.

Audia S, Rossato M, Santegoets K, Spijkers S, Wichers C, Bekker C, Bloem A, Boon L, Flinsenberg T, Compeer E, van den Broek T, Facy O, Ortega-Deballon P, Berthier S, Leguy-Seguin V, Martin L, Ciudad M, Samson M, Trad M, Lorcerie B, Janikashvili N, Saas P, Bonnotte B, Radstake TR

Blood. 2014 Oct 30;124(18):2858-66

Gastric adenocarcinoma in familial adenomatous polyposis can occur without previous lesions.

Ravoire A, Faivre L, Degrolard-Courcet E, Bedenne L, Olschwang S, Rat P, Ortega-Deballon P

J Gastrointest Cancer. 2014 Sep;45(3):377-9

Abdominal binders after laparotomy: review of the literature and French survey of policies.

Bouvier A, Rat P, Drissi-Chbihi F, Bonnetain F, Lacaine F, Mariette C, Ortega-Deballon P,

Hernia. 2014 Aug;18(4):501-6

Delay before implanting a port-a-cath after removing the previous one because of infection.

Simone G, Piroth L, Lakkis Z, Rat P, Heyd B, Ortega-Deballon P

Med Mal Infect. 2014 Jul;44(7):315-20

Perforation of bowel lymphoma: beware of atypical presentations.

Lagoutte N, Doussot A, Leung U, Facy O, Bastie JN, Rat P, Ortega-Deballon P

J Gastrointest Cancer. 2014 Jun;45(2):121-5

Bevacizumab efficacy in metastatic colorectal cancer is dependent on primary tumor resection.

Ghiringhelli F, Bichard D, Limat S, Lorgis V, Vincent J, Borg C, Berthou J, Orry D, Ortega-Deballon P, Lakkis Z, Facy O, Heyd B, Rat P, Nerich V, Ladoire S

Ann Surg Oncol. 2014 May;21(5):1632-40