Dr LAGROST Laurent

Fiche personne

Coordonnées

Inserm UMR 1231 CTM
7 bd Jeanne d'Arc
BP 87900
21079 DIJON Cedex

03 80 39 32 63

Territoire

Bourgogne

Statut

Chercheur

Affiliation

Inserm UMR 1231 "Centre de recherche translationnelle en médecine moléculaire (CTM)" (Inserm UMR1231 CTM)

Équipes/plateformes

UMR 1231 - Equipe "Protéines de transfert des lipides et métabolisme des lipoprotéines (LIPNESS)"

Publications

Plasmalogen remodeling modulates macrophage response to cytotoxic oxysterols and atherosclerotic plaque vulnerability.

Jalil A, Pilot T, Bourgeois T, Laubriet A, Li X, Diedisheim M, Deckert V, Magnani C, Le Guern N, Pais de Barros JP, Nguyen M, Pallot G, Vouilloz A, Proukhnitzky L, Hermetet F, Aires V, Lesniewska E, Lagrost L, Auwerx J, Le Goff W, Venteclef N, Steinmetz E, Thomas C, Masson D

Cell Rep Med. 2025 05 6;:102131

Risk factors and prognostic value of endotoxemia in patients with acute myocardial infarction.

Nguyen M, Putot A, Masson D, Cottin Y, Gautier T, Tribouillard L, Rérole AL, Guinot PG, Maza M, Pais de Barros JP, Deckert V, Farnier M, Lagrost L, Zeller M

Front Cardiovasc Med. 2024 06 25;11:1419001

Plasma citrulline concentration and plasma LPS detection among critically ill patients a prospective observational study.

Chaignat C, Lagrost L, Moretto K, de Barros JP, Winiszewski H, Grober J, Saas P, Piton G

J Crit Care. 2023 10 3;79:154438

Role of apolipoprotein C1 in lipoprotein metabolism, atherosclerosis and diabetes: a systematic review.

Rouland A, Masson D, Lagrost L, Vergès B, Gautier T, Bouillet B

Cardiovasc Diabetol. 2022 12 5;21(1):272

Increased Weight Gain and Insulin Resistance in HF-Fed PLTP Deficient Mice Is Related to Altered Inflammatory Response and Plasma Transport of Gut-Derived LPS.

Lebrun LJ, Pallot G, Nguyen M, Tavernier A, Dusuel A, Pilot T, Deckert V, Dugail I, Le Guern N, Pais De Barros JP, Benkhaled A, Choubley H, Lagrost L, Masson D, Gautier T, Grober J

Int J Mol Sci. 2022 10 30;23(21):

Possible mediators of metabolic endotoxemia in women with obesity and women with obesity-diabetes in The Gambia.

Jobe M, Agbla SC, Todorcevic M, Darboe B, Danso E, de Barros JP, Lagrost L, Karpe F, Prentice AM

Int J Obes (Lond). 2022 08 6;:

The expanding role of lyso-phosphatidylcholine acyltransferase-3 (LPCAT3), a phospholipid-remodeling enzyme, in health and disease.

Lagrost L, Masson D

Curr Opin Lipidol. 2022 Feb 14;:

HDL infusion protects from acute graft-versus-host disease in experimental allogeneic hematopoietic cell transplantation.

Chagué C, Gautier T, Dal Zuffo L, Pais de Barros JP, Wetzel A, Tarris G, Pallot G, Martin L, Valmary-Degano S, Deckert V, Lagrost L, Daguindau E, Saas P

Am J Transplant. 2022 Jan 17;:

New therapeutic horizons for plasma phospholipid transfer protein (PLTP): Targeting endotoxemia, infection and sepsis.

Gautier T, Deckert V, Nguyen M, Desrumaux C, Masson D, Lagrost L

Pharmacol Ther. 2021 Dec 30;:108105

Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.

Leskelä J, Toppila I, Härma MA, Palviainen T, Salminen A, Sandholm N, Pietiäinen M, Kopra E, Pais de Barros JP, ,Lassenius MI, Kumar A, Harjutsalo V, Roslund K, Forsblom C, Loukola A, Havulinna AS, Lagrost L, Salomaa V, Groop PH, Perola M, Kaprio J, Lehto M, Pussinen PJ

J Am Heart Assoc. 2021 Oct 20;:e022482

High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia.

Nguyen M, Bourredjem A, Piroth L, Bouhemad B, Jalil A, Pallot G, Le Guern N, Thomas C, Pilot T, Bergas V, Choubley H, Quenot JP, Charles PE, Lagrost L, Deckert V, de Barros JP, Guinot PG, Masson D, Binquet C, Gautier T, Blot M,

Sci Rep. 2021 05 24;11(1):10824

Human apolipoprotein C1 transgenesis reduces atherogenesis in hypercholesterolemic rabbits.

Gautier T, Deckert V, Aires V, Le Guern N, Proukhnitzky L, Patoli D, Lemaire S, Maquart G, Bataille A, Xolin M, Magnani C, Masson D, Harscoët E, Da Silva B, Houdebine LM, Jolivet G, Lagrost L

Atherosclerosis. 2021 Jan 12;320:10-18

Endotoxin Mass Concentration in Plasma Is Associated With Mortality in a Multicentric Cohort of Peritonitis-Induced Shock.

Payen D, Dupuis C, Deckert V, Pais de Barros JP, Rérole AL, Lukaszewicz AC, Coudroy R, Robert R, Lagrost L

Front Med (Lausanne). 2021 ;8:749405

Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein.

Nguyen M, Pallot G, Jalil A, Tavernier A, Dusuel A, Le Guern N, Lagrost L, Pais de Barros JP, Choubley H, Bergas V, Guinot PG, Masson D, Bouhemad B, Gautier T

Front Immunol. 2021 ;12:622935

New Insights on End-Stage Renal Disease and Healthy Individual Gut Bacterial Translocation: Different Carbon Composition of Lipopolysaccharides and Different Impact on Monocyte Inflammatory Response.

Adda-Rezig H, Carron C, Pais de Barros JP, Choubley H, Charron É, Rérole AL, Laheurte C, Louvat P, Gaiffe É, Simula-Faivre D, Deckert V, Lagrost L, Saas P, Ducloux D, Bamoulid J

Front Immunol. 2021 ;12:658404

Deletion of lysophosphatidylcholine acyltransferase 3 in myeloid cells worsens hepatic steatosis after a high-fat diet.

Bourgeois T, Jalil A, Thomas C, Magnani C, Le Guern N, Gautier T, Pais de Barros JP, Bergas V, Choubley H, Mazzeo L, Menegaut L, Josiane Lebrun L, Van Dongen K, Xolin M, Jourdan T, Buch C, Labbé J, Saas P, Lagrost L, Masson D, Grober J

J Lipid Res. 2020 Dec 17;62:100013

Human cholesteryl ester transfer protein lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice.

Dusuel A, Deckert V, Pais de Barros JP, van Dongen K, Choubley H, Charron É, Le Guern N, Labbé J, Mandard S, Grober J, Lagrost L, Gautier T

J Lipid Res. 2020 Dec 15;62:100011

Deletion of lysophosphatidylcholine acyltransferase3 in myeloid cells worsens hepatic steatosis after a high fat diet.

Bourgeois T, Jalil A, Thomas C, Magnani C, Le Guern N, Gautier T, Pais DE Barros JP, Bergas V, Choubley H, Mazzeo L, Menegaut L, Lebrun L, Van Dongen K, Xolin M, Jourdan T, Buch C, Labbé J, Saas P, Lagrost L, Masson D, Grober J

J Lipid Res. 2020 Dec 11;:

Human CETP lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice.

Dusuel A, Deckert V, Pais DE Barros JP, Van Dongen K, Choubley H, Charron E, Le Guern N, Labbé J, Mandard S, Grober J, Lagrost L, Gautier T

J Lipid Res. 2020 Dec 9;:

LDL apheresis as an alternate method for plasma LPS purification in healthy volunteers and dyslipidemic and septic patients.

Dargent A, Pais de Barros JP, Saheb S, Bittar R, Le Goff W, Carrié A, Gautier T, Fournel I, Rerole AL, Choubley H, Masson D, Lagrost L, Quenot JP

J Lipid Res. 2020 Dec;61(12):1776-1783

LDL apheresis as an alternate method for plasma LPS purification in healthy volunteers and dyslipidemic and septic patients.

Dargent A, Pais de Barros JP, Saheb S, Bittar R, Le Goff W, Carrié A, Gautier T, Fournel I, Rerole AL, Choubley H, Masson D, Lagrost L, Quenot JP

J Lipid Res. 2020 Dec;61(12):1776-1783

Lipoproteins LDL versus HDL as nanocarriers to target either cancer cells or macrophages.

Hadi T, Ramseyer C, Gautier T, Bellaye PS, Lopez T, Schmitt A, Sarah F, Yesylevskyy S, Minervini T, Douhard R, Dondaine L, Proukhnitzky L, Messaoudi S, Wendremaire M, Moreau M, Neiers F, Collin B, Denat F, Lagrost L, Garrido C, Lirussi F

JCI Insight. 2020 Nov 24;:

LDL-apheresis as an alternate method for plasma LPS purification in healthy volunteers, dyslipidemic and septic patients.

Dargent A, Pais DE Barros JP, Saheb S, Bittar R, Le Goff W, Carrié A, Gautier T, Fournel I, Rérole AL, Choubley H, Masson D, Lagrost L, Quenot JP

J Lipid Res. 2020 Oct 9;:

Inhibition of mitophagy drives macrophage activation and anti-bacterial defense during sepsis.

Patoli D, Mignotte F, Deckert V, Dusuel A, Dumont A, Rieu A, Jalil A, Van Dongen K, Bourgeois T, Gautier T, Magnani C, Le Guern N, Mandard S, Bastin J, Djouadi F, Schaeffer C, Guillaumot N, Narce M, Nguyen M, Guy J, Dargent A, Quenot JP, Rialland M, Masson D, Auwerx J, Lagrost L, Thomas C

J. Clin. Invest.. 2020 Aug 6;:

The deficit in folate and vitamin B12 triggers liver macrovesicular steatosis and inflammation in rats with dextran sodium sulfate-induced colitis.

Harb Z, Deckert V, Bressenot AM, Christov C, Guéant-Rodriguez RM, Raso J, Alberto JM, de Barros JP, Umoret R, Biroulet LP, Lagrost L, Bronowicki JP, Guéant JL

J. Nutr. Biochem.. 2020 May 20;84:108415

Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages.

Ménégaut L, Thomas C, Jalil A, Julla JB, Magnani C, Ceroi A, Basmaciyan L, Dumont A, Le Goff W, Mathew MJ, Rébé C, Dérangère V, Laubriet A, Crespy V, Pais de Barros JP, Steinmetz E, Venteclef N, Saas P, Lagrost L, Masson D

Cell Rep. 2020 May 19;31(7):107665

Nanosphere-shaped ammonio methacrylate copolymers: converting a pharmaceutical inactive ingredient to efficient therapeutics for experimental colitis.

Moulari B, Shetab Boushehri MA, Pais de Barros JP, Faber T, Béduneau A, Lagrost L, Pellequer Y, Lamprecht A

Nanoscale. 2020 Apr 21;:

Improved quantification of plasma lipopolysaccharide (LPS) burden in sepsis using 3-hydroxy myristate (3HM): a cohort study.

Dargent A, Pais De Barros JP, Ksiazek E, Fournel I, Dusuel A, Rerole AL, Choubley H, Masson D, Lagrost L, Quenot JP

Intensive Care Med. 2019 Aug 26;:

Revisiting the Role of LXRs in PUFA Metabolism and Phospholipid Homeostasis.

Jalil A, Bourgeois T, Ménégaut L, Lagrost L, Thomas C, Masson D

Int J Mol Sci. 2019 Aug 2;20(15):

Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract.

Aires V, Labbé J, Deckert V, Pais de Barros JP, Boidot R, Haumont M, Maquart G, Le Guern N, Masson D, Prost-Camus E, Prost M, Lagrost L

Sci Rep. 2019 Jun 24;9(1):9134

Antibody Treatment against Angiopoietin-Like 4 Reduces Pulmonary Edema and Injury in Secondary Pneumococcal Pneumonia.

Li L, Foo BJW, Kwok KW, Sakamoto N, Mukae H, Izumikawa K, Mandard S, Quenot JP, Lagrost L, Teh WK, Singh Kohli G, Zhu P, Choi H, Buist ML, Seet JE, Yang L, He F, Kwong Chow VT, Tan NS

MBio. 2019 Jun 4;10(3):

Plasma apolipoprotein C1 concentration is associated with plasma triglyceride concentration but not with visceral fat and liver fat content in people with type 1 diabetes.

Bouillet B, Gautier T, Rouland A, Duvillard L, Petit JM, Lagrost L, Vergès B

Acta Diabetol. 2019 May 22;:

CETP activity is not associated with carotid intima-media thickness in patients with poorly controlled type 2 diabetes.

Bouillet B, Gautier T, Terriat B, Lagrost L, Verges B, Petit JM

Acta Diabetol. 2019 Apr 12;:

End-Stage Renal Disease-Associated Gut Bacterial Translocation: Evolution and Impact on Chronic Inflammation and Acute Rejection After Renal Transplantation.

Carron C, Pais de Barros JP, Gaiffe E, Deckert V, Adda-Rezig H, Roubiou C, Laheurte C, Masson D, Simula-Faivre D, Louvat P, Moulin B, Frimat L, Rieu P, Mousson C, Durrbach A, Heng AE, Saas P, Ducloux D, Lagrost L, Bamoulid J

Front Immunol. 2019 ;10:1630

Polysaccharide Chain Length of Lipopolysaccharides From Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity .

Sali W, Patoli D, Pais de Barros JP, Labbé J, Deckert V, Duhéron V, Le Guern N, Blache D, Chaumont D, Lesniewska E, Gasquet B, Paul C, Moreau M, Denat F, Masson D, Lagrost L, Gautier T

Front Microbiol. 2019 ;10:1774

A chronic LPS-induced low-grade inflammation fails to reproduce in lean mice the impairment of preference for oily solution found in diet-induced obese mice.

Bernard A, Ancel D, Passilly-Degrace P, Landrier JF, Lagrost L, Besnard P

Biochimie. 2018 Aug 10;:

Author Correction: Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids.

Besnard P, Christensen JE, Brignot H, Bernard A, Passilly-Degrace P, Nicklaus S, Pais de Barros JP, Collet X, Lelouvier B, Servant F, Blasco-Baque V, Verges B, Lagrost L, Feron G, Burcelin R

Sci Rep. 2018 Jun 22;8(1):9773

Circulating levels of 3-hydroxymyristate, a direct quantification of endotoxemia in non-infected cirrhotic patients.

Weil D, Pais de Barros JP, Mourey G, Laheurte C, Cypriani B, Badet N, Delabrousse E, Grandclément E, Di Martino V, Saas P, Lagrost L, Thévenot T

Liver Int.. 2018 Jun 22;:

The Transplantation of ω3 PUFA-Altered Gut Microbiota of Fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders.

Bidu C, Escoula Q, Bellenger S, Spor A, Galan M, Geissler A, Bouchot A, Dardevet D, Morio-Liondor B, Cani PD, Lagrost L, Narce M, Bellenger J

Diabetes. 2018 May 23;:

LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis.

Thomas C, Jalil A, Magnani C, Ishibashi M, Queré R, Bourgeois T, Bergas V, Ménégaut L, Patoli D, Le Guern N, Labbé J, Gautier T, de Barros JPP, Lagrost L, Masson D

Atherosclerosis. 2018 May 18;:

Plasma phospholipid transfer protein (PLTP) as an emerging determinant of the adaptive immune response.

Desrumaux C, Lagrost L

Cell. Mol. Immunol.. 2018 May 7;:

Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids.

Besnard P, Christensen JE, Brignot H, Bernard A, Passilly-Degrace P, Nicklaus S, Pais de Barros JP, Collet X, Lelouvier B, Servant F, Blasco V, Verges B, Lagrost L, Feron G, Burcelin R

Sci Rep. 2018 Apr 30;8(1):6742

Deletion of plasma increases microglial phagocytosis and reduces cerebral amyloid-β deposition in the J20 mouse model of Alzheimer's disease.

Mansuy M, Baille S, Canet G, Borie A, Cohen-Solal C, Vignes M, Perrier V, Chevallier N, Le Guern N, Deckert V, Lagrost L, Givalois L, Desrumaux C

Oncotarget. 2018 Apr 13;9(28):19688-19703

Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice.

Desrumaux CM, Mansuy M, Lemaire S, Przybilski J, Le Guern N, Givalois L, Lagrost L

Front Behav Neurosci. 2018 ;12:310

PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity.

Audo R, Deckert V, Daien CI, Che H, Elhmioui J, Lemaire S, Pais de Barros JP, Desrumaux C, Combe B, Hahne M, Lagrost L, Morel J

PLoS ONE. 2018 ;13(3):e0193815

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.

Lebrun LJ, Lenaerts K, Kiers D, Pais de Barros JP, Le Guern N, Plesnik J, Thomas C, Bourgeois T, Dejong CHC, Kox M, Hundscheid IHR, Khan NA, Mandard S, Deckert V, Pickkers P, Drucker DJ, Lagrost L, Grober J

Cell Rep. 2017 Oct 31;21(5):1160-1168

Plasma cholesterol level determines in vivo prion propagation.

Perrier V, Imberdis T, Lafon PA, Cefis M, Wang Y, Huetter E, Arnaud JD, Alvarez-Martinez T, Le Guern N, Maquart G, Lagrost L, Desrumaux C

J. Lipid Res.. 2017 Aug;:

Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis.

Deckert V, Lemaire S, Ripoll PJ, de Barros JP, Labbé J, Borgne CC, Turquois V, Maquart G, Larose D, Desroche N, Ménétrier F, Le Guern N, Lebrun LJ, Desrumaux C, Gautier T, Grober J, Thomas C, Masson D, Houdebine LM, Lagrost L

Sci Rep. 2017 Jun;7(1):3053

Fatty acid metabolism in macrophages: a target in cardio-metabolic diseases.

Ménégaut L, Thomas C, Lagrost L, Masson D

Curr. Opin. Lipidol.. 2017 Feb;28(1):19-26

Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus.

Brenachot X, Gautier T, Nédélec E, Deckert V, Laderrière A, Nuzzaci D, Rigault C, Lemoine A, Pénicaud L, Lagrost L, Benani A

Front Neurosci. 2017 ;11:245

Is It Time to Reconsider the Lipopolysaccharide Paradigm in Acute Graft-Versus-Host Disease?

Daguindau E, Gautier T, Chagué C, Pais de Barros JP, Deckert V, Lagrost L, Saas P

Front Immunol. 2017 ;8:952

LXR agonist treatment of blastic plasmacytoid dendritic cell neoplasm restores cholesterol efflux and triggers apoptosis.

Ceroi A, Masson D, Roggy A, Roumier C, Chagué C, Gauthier T, Philippe L, Lamarthée B, Angelot-Delettre F, Bonnefoy F, Perruche S, Biichle S, Preudhomme C, Macintyre E, Lagrost L, Garnache-Ottou F, Saas P

Blood. 2016 Dec;128(23):2694-2707

Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization.

Desrumaux C, Lemaire-Ewing S, Ogier N, Yessoufou A, Hammann A, Sequeira-Le Grand A, Deckert V, Pais de Barros JP, Le Guern N, Guy J, Khan NA, Lagrost L

Cell. Mol. Immunol.. 2016 Nov;13(6):795-804

Plasma apolipoprotein C1 concentration is associated with plasma triglyceride concentration, but not visceral fat, in patients with type 2 diabetes.

Bouillet B, Gautier T, Aho LS, Duvillard L, Petit JM, Lagrost L, Vergès B

Diabetes Metab.. 2016 Sep;42(4):263-6

Specific enrichment of 2-arachidonoyl-lysophosphatidylcholine in carotid atheroma plaque from type 2 diabetic patients.

Ménégaut L, Masson D, Abello N, Denimal D, Truntzer C, Ducoroy P, Lagrost L, Pais de Barros JP, Athias A, Petit JM, Martin L, Steinmetz E, Kretz B

Atherosclerosis. 2016 Aug;251:339-47

The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation.

Ceroi A, Delettre FA, Marotel C, Gauthier T, Asgarova A, Biichlé S, Duperrier A, Mourey G, Perruche S, Lagrost L, Masson D, Saas P

Haematologica. 2016 Mar;101(3):e72-6

The potential of cholesteryl ester transfer protein as a therapeutic target.

Gautier T, Masson D, Lagrost L

Expert Opin. Ther. Targets. 2016 ;20(1):47-59

Insulin response dysregulation explains abnormal fat storage and increased risk of diabetes mellitus type 2 in Cohen Syndrome.

Limoge F, Faivre L, Gautier T, Petit JM, Gautier E, Masson D, Jego G, El Chehadeh-Djebbar S, Marle N, Carmignac V, Deckert V, Brindisi MC, Edery P, Ghoumid J, Blair E, Lagrost L, Thauvin-Robinet C, Duplomb L

Hum Mol Genet. 2015 Sep 10. pii: ddv366.