Dr FROCHOT Céline

A Deep-Red-Absorbing Osmium(II)-Based Photosensitizer Evokes Pyroptosis by Targeting Glutamine Metabolism and Impairing Cell Redox Homeostasis.

Zhang Y, Xiao Z, Southwell JW, Gao R, Saubaméa B, Moinard M, Arnoux P, Frochot C, Mesdom P, Gasser G

J Am Chem Soc. 2026 04 21;:

Targeted photodynamic therapy for pancreatic cancer: recent innovations from fundamentals to and clinical applications (2020-2025).

Sarr S, Godard J, Valzer E, Czuba E, Acherar S, Barberi-Heyob M, Blanchard-Desce M, Boleslawski E, Brégier F, Bulin AL, Burckel H, Daouk J, da Silva A, Daniel J, Delhem N, Dewalle AS, Frochot C, Gasser G, Heitz V, Jonckheere N, Lemercier G, Mordon S, Noël G, Novell A, Ravanat JL, Roth G, Sol V

Chem Commun (Camb). 2026 01 22;:

Beta-lactam antibiotics under light: optical and photochemical characterization.

Salani R, Deana AM, Ñunez SC, Frochot C, de Fátima Teixeira Silva D, Pavani C

Photochem Photobiol Sci. 2025 12 15;:

Photodynamic ablation of floating lung cancer cells using PVA and TPGS emulsified PLGA nanoparticles loaded with pyropheophorbide-a.

Pramual S, Arnoux P, Lirdprapamongkol K, Frochot C, Jouan-Hureaux V, Barberi-Heyob M, Svasti J

J Photochem Photobiol B. 2025 11 26;274:113318

A Triple Threat Against Ovarian Cancer: Os(II)-Pt(IV)-Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction.

Redrado M, Acharya S, Mesdom P, Babu T, Southwell JW, Oliveira LS, Hidalgo S, Arnoux P, Frochot C, Gibson D, Gasser G

Angew Chem Int Ed Engl. 2025 10 5;:e202518623

Synthesis, Characterization, and Biological Evaluation of Iron(III)--Heterocyclic Carbene Complexes as Photosensitizers for Photodynamic Therapy and Chemotherapeutics against Cancer.

Zhou L, Salluce G, Mesdom P, Redrado M, Gourdon-Grünewaldt L, Hidalgo S, Blacque O, Arnoux P, Frochot C, Cariou K, Gasser G

Inorg Chem. 2025 08 14;:

Herpes Simplex Treated With Antimicrobial Photodynamic Therapy: Randomized Controlled Trial.

La Selva A, Bezerra DT, Zerbinati RM, Gonçalves MLL, Navarro RS, Bello-Silva MS, Ando-Suguimoto ES, Aranha ACC, Braz-Silva PH, Ramalho KM, Motta LJ, Fernandes KPS, Bussadori SK, Mesquita-Ferrari RA, Frochot C, Horliana ACRT

J Oral Pathol Med. 2025 06 8;:

Viscous methylene blue formulation for antimicrobial photodynamic therapy in dentistry.

Monteiro CM, Gonçalves JMLA, Machado GB, Chiarelli-Neto O, Prates RA, Frochot C, Pavani C

Sci Rep. 2025 05 6;15(1):15751

Lanthanides-Based Nanoparticles Conjugated with Rose Bengal for FRET-Mediated X-Ray-Induced PDT.

Dhaini B, Daouk J, Schohn H, Arnoux P, Jouan-Hureaux V, Moussaron A, Hagege A, Achard M, Acherar S, Hamieh T, Frochot C

Pharmaceuticals (Basel). 2025 05 1;18(5):

Synthesis, Physicochemical Properties and Anti-Fungal Activities of New -Arylporphyrins.

Mkacher H, Chaâbane-Banaoues R, Hrichi S, Arnoux P, Babba H, Frochot C, Nasri H, Acherar S

Int J Mol Sci. 2025 02 25;26(5):

Prevalence of Nasal Carriage in Patients Undergoing Hemodialysis and Assessment of Risk Factors: A Cross-Sectional Study of Outpatients at a University Hospital.

Bezerra DT, Mesquita-Ferrari RA, Fernandes KPS, Bussadori SK, Motta LJ, Ando-Suguimoto ES, Frochot C, Perini AM, Rossi F, Mimica MJ, Pereira BJ, Horliana ACRT

Healthcare (Basel). 2025 01 26;13(3):

Energy Transfer between AGuIX Nanoparticles and Photofrin under Light or X-ray Excitation for PDT Applications.

Dhaini B, Arnoux P, Daouk J, Lux F, Tillement O, Hagège A, Hamieh T, Shafirstein G, Frochot C

Pharmaceuticals (Basel). 2024 08 5;17(8):

Targeted photodynamic therapy using a Vectorized photosensitizer coupled to folic acid analog induces ovarian tumor cell death and inhibits IL-6-mediated inflammation.

Boidin L, Moinard M, Moussaron A, Merlier M, Moralès O, Grolez GP, Baydoun M, Mohd-Gazzali A, Tazizi MHDM, Allah HHA, Kerbage Y, Arnoux P, Acherar S, Frochot C, Delhem N

J Control Release. 2024 05 22;:

Chemistry and light: an adventure into probing, understanding and controlling events at the molecular scale.

Frochot C, Werts MHV, Williams RM

Photochem Photobiol Sci. 2024 04 24;:

Synthesis and preliminary anticancer evaluation of photo-responsive prodrugs of hydroxymethylene bisphosphonate alendronate.

Descamps A, Arnoux P, Frochot C, Barbault F, Deschamp J, Monteil M, Migianu-Griffoni E, Legigan T, Lecouvey M

Eur J Med Chem. 2024 03 5;269:116307

Easy and versatile cellulosic support inhibiting broad spectrum strains: synergy between photodynamic antimicrobial therapy and polymyxin B.

Le Guern F, Ouk TS, Arnoux P, Frochot C, Sol V

Photochem Photobiol Sci. 2024 02 1;:

LASU: an efficient and stable phthalocyanine dye with tolerable safety profile for self-disinfecting anti-COVID textiles activated by ambient light.

Efimov A, Dagallier C, Frochot C, Myrzakhmetov B, Arnoux P, Heinonen T, Mannerström M, Toimela T, Ahmed Z, Audibert JF, Habermeyer B, Mordon S, Pansu RB

Photodiagnosis Photodyn Ther. 2024 01 16;:103978

Increasing the π-Expansive Ligands in Ruthenium(II) Polypyridyl Complexes: Synthesis, Characterization, and Biological Evaluation for Photodynamic Therapy Applications.

Pozza MD, Mesdom P, Abdullrahman A, Prieto Otoya TD, Arnoux P, Frochot C, Niogret G, Saubaméa B, Burckel P, Hall JP, Hollenstein M, Cardin CJ, Gasser G

Inorg Chem. 2023 11 1;:

Ru(ii)/Os(ii)-based carbonic anhydrase inhibitors as photodynamic therapy photosensitizers for the treatment of hypoxic tumours.

Wang Y, Mesdom P, Purkait K, Saubaméa B, Burckel P, Arnoux P, Frochot C, Cariou K, Rossel T, Gasser G

Chem Sci. 2023 11 1;14(42):11749-11760

Ru(II)-Cyanine Complexes as Promising Photodynamic Photosensitizers for the Treatment of Hypoxic Tumours with Highly Penetrating 770 nm Near-Infrared Light.

Gandioso A, Izquierdo-García E, Mesdom P, Arnoux P, Demeubayeva N, Burckel P, Saubaméa B, Bosch M, Frochot C, Marchan V, Gasser G

Chemistry. 2023 08 7;:e202301742

New Crystal Form of Human Neuropilin-1 b1 Fragment with Six Electrostatic Mutations Complexed with KDKPPR Peptide Ligand.

Goudiaby I, Malliavin TE, Mocchetti E, Mathiot S, Acherar S, Frochot C, Barberi-Heyob M, Guillot B, Favier F, Didierjean C, Jelsch C

Molecules. 2023 07 24;28(14):

Folate Receptor Targeted Photodynamic Therapy: A Novel Way to Stimulate Anti-Tumor Immune Response in Intraperitoneal Ovarian Cancer.

Baydoun M, Boidin L, Leroux B, Vignion-Dewalle AS, Quilbe A, Grolez GP, Azaïs H, Frochot C, Moralès O, Delhem N

Int J Mol Sci. 2023 07 10;24(14):

A Novel Near-IR Absorbing Ruthenium(II) Complex as Photosensitizer for Photodynamic Therapy and its Cetuximab Bioconjugates.

Martínez-Alonso M, Gandioso A, Thibaudeau C, Qin X, Arnoux P, Demeubayeva N, Guérineau V, Frochot C, Jung AC, Gaiddon C, Gasser G

Chembiochem. 2023 04 5;:e202300203

Targeting Glioblastoma-Associated Macrophages for Photodynamic Therapy Using AGuIX-Design Nanoparticles.

Lerouge L, Gries M, Chateau A, Daouk J, Lux F, Rocchi P, Cedervall J, Olsson AK, Tillement O, Frochot C, Acherar S, Thomas N, Barberi-Heyob M

Pharmaceutics. 2023 03 20;15(3):

Synthesis, Photophysical Characterization and Evaluation of Biological Properties of C7, a Novel Symmetric -Imidazolium--Heterocycle.

Kunstek H, Wang M, Hussein H, Dhouib I, Khemakhem B, Risler A, Philippot S, Frochot C, Arnoux P, Fournier B, Varbanov M, Dumarçay-Charbonnier F

Microorganisms. 2023 02 16;11(2):

Antimicrobial Photodynamic Therapy in the Nasal Decolonization of Maintenance Hemodialysis Patients: A Pilot Randomized Trial.

Bezerra DT, La Selva A, Cecatto RB, Deana AM, Prates RA, Bussadori SK, Mesquita Ferrari RA, Motta LJ, Santos Fernandes KP, Martimbianco AL, Frochot C, Pereira BJ, Rossi F, Mimica MJ, Ratto Tempestini Horliana AC

Am J Kidney Dis. 2022 11 14;:

tLyp-1: A peptide suitable to target NRP-1 receptor.

Larue L, Kenzhebayeva B, Al-Thiabat MG, Jouan-Hureaux V, Mohd-Gazzali A, Wahab HA, Boura C, Yeligbayeva G, Nakan U, Frochot C, Acherar S

Bioorg Chem. 2022 10 23;130:106200

Importance of Rose Bengal Loaded with Nanoparticles for Anti-Cancer Photodynamic Therapy.

Dhaini B, Wagner L, Moinard M, Daouk J, Arnoux P, Schohn H, Schneller P, Acherar S, Hamieh T, Frochot C

Pharmaceuticals (Basel). 2022 08 31;15(9):

Residual Microscopic Peritoneal Metastases after Macroscopic Complete Cytoreductive Surgery for Advanced High-Grade Serous Ovarian Carcinoma: A Target for Folate Receptor Targeted Photodynamic Therapy?

Moinard M, Augustin J, Carrier M, Da Maïa E, Penel A, Belghiti J, Nikpayam M, Gonthier C, Canlorbe G, Acherar S, Delhem N, Frochot C, Uzan C, Azaïs H

Pharmaceuticals (Basel). 2022 08 22;15(8):

Lipophilicity prediction of 3 photosensitizers by liquid-liquid extraction, HPLC, and DFT methods.

Myrzakhmetov B, Honorien J, Arnoux P, Fournet R, Tsoy I, Frochot C

Luminescence. 2022 07 15;:

Preliminary Study of New Gallium-68 Radiolabeled Peptide Targeting NRP-1 to Detect Brain Metastases by Positron Emission Tomography.

Moussaron A, Jouan-Hureaux V, Collet C, Pierson J, Thomas N, Choulier L, Veran N, Doyen M, Arnoux P, Maskali F, Dumas D, Acherar S, Barberi-Heyob M, Frochot C

Molecules. 2021 Nov 30;26(23):

Study of Cytotoxic and Photodynamic Activities of Dyads Composed of a Zinc Phthalocyanine Appended to an Organotin.

Toubia I, Nguyen C, Diring S, Pays M, Mattana E, Arnoux P, Frochot C, Gary-Bobo M, Kobeissi M, Odobel F

Pharmaceuticals (Basel). 2021 Apr 28;14(5):

Terbium-Based AGuIX-Design Nanoparticle to Mediate X-ray-Induced Photodynamic Therapy.

Daouk J, Iltis M, Dhaini B, Béchet D, Arnoux P, Rocchi P, Delconte A, Habermeyer B, Lux F, Frochot C, Tillement O, Barberi-Heyob M, Schohn H

Pharmaceuticals (Basel). 2021 Apr 22;14(5):

Synthesis of New Water Soluble β-Cyclodextrin@Curcumin Conjugates and In Vitro Safety Evaluation in Primary Cultures of Rat Cortical Neurons.

Ben Mihoub A, Acherar S, Frochot C, Malaplate C, Yen FT, Arab-Tehrany E

Int J Mol Sci. 2021 Mar 23;22(6):

Photophysical and Bactericidal Properties of Pyridinium and Imidazolium Porphyrins for Photodynamic Antimicrobial Chemotherapy.

Le Guern F, Ouk TS, Yerzhan I, Nurlykyz Y, Arnoux P, Frochot C, Leroy-Lhez S, Sol V

Molecules. 2021 Feb 20;26(4):

Design of a Targeting and Oxygen-Independent Platform to Improve Photodynamic Therapy: A Proof of Concept.

Larue L, Moussounda Moussounda Koumba T, Le Breton N, Vileno B, Arnoux P, Jouan-Hureaux V, Boura C, Audran G, Bikanga R, Marque SRA, Acherar S, Frochot C

ACS Appl Bio Mater. 2021 Feb 15;4(2):1330-1339

Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a and Photofrin in Different Conditions.

Myrzakhmetov B, Arnoux P, Mordon S, Acherar S, Tsoy I, Frochot C

Pharmaceuticals (Basel). 2021 Feb 9;14(2):

New Phenalenone Derivatives: Synthesis and Evaluation of Their Singlet Oxygen Quantum Yield.

Godard J, Brégier F, Arnoux P, Myrzakhmetov B, Champavier Y, Frochot C, Sol V

ACS Omega. 2020 Nov 3;5(43):28264-28272

Polythiophenes with Cationic Phosphonium Groups as Vectors for Imaging, siRNA Delivery, and Photodynamic Therapy.

Lichon L, Kotras C, Myrzakhmetov B, Arnoux P, Daurat M, Nguyen C, Durand D, Bouchmella K, Ali LMA, Durand JO, Richeter S, Frochot C, Gary-Bobo M, Surin M, Clément S

Nanomaterials (Basel). 2020 Jul 22;10(8):

Interplay between Cellular Uptake, Intracellular Localization and the Cell Death Mechanism in Triphenylamine-Mediated Photoinduced Cell Death.

Chennoufi R, Trinh ND, Simon F, Bordeau G, Naud-Martin D, Moussaron A, Cinquin B, Bougherara H, Rambaud B, Tauc P, Frochot C, Teulade-Fichou MP, Mahuteau-Betzer F, Deprez E

Sci Rep. 2020 Apr 23;10(1):6881

Photodynamic Therapy Using a New Folate Receptor-Targeted Photosensitizer on Peritoneal Ovarian Cancer Cells Induces the Release of Extracellular Vesicles with Immunoactivating Properties.

Baydoun M, Moralès O, Frochot C, Ludovic C, Leroux B, Thecua E, Ziane L, Grabarz A, Kumar A, de Schutter C, Collinet P, Azais H, Mordon S, Delhem N

J Clin Med. 2020 Apr 21;9(4):

Inclusion complex vs. conjugation of hydrophobic photosensitizers with β-cyclodextrin: Improved disaggregation and photodynamic therapy efficacy against glioblastoma cells.

Ben Mihoub A, Youssef Z, Colombeau L, Jouan-Hureaux V, Arnoux P, Frochot C, Vanderesse R, Acherar S

Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110604

Overcoming the diverse mechanisms of multidrug resistance in lung cancer cells by photodynamic therapy using pTHPP-loaded PLGA-lipid hybrid nanoparticles.

Pramual S, Lirdprapamongkol K, Jouan-Hureaux V, Barberi-Heyob M, Frochot C, Svasti J, Niamsiri N

Eur J Pharm Biopharm. 2020 Feb 26;:

A global approach for the development of photodynamic therapy of peritoneal metastases regardless of their origin.

Azaïs H, Rebahi C, Baydoun M, Serouart B, Ziane L, Moralès O, Frochot C, Colombeau L, Thécua E, Collinet P, Delhem N, Mordon S

Photodiagnosis Photodyn Ther. 2020 Feb 12;:101683

An Efficient Photodynamic Therapy Treatment for Human Pancreatic Adenocarcinoma.

Quilbe A, Moralès O, Baydoun M, Kumar A, Mustapha R, Murakami T, Leroux B, de Schutter C, Thecua E, Ziane L, Colombeau L, Frochot C, Mordon S, Delhem N

J Clin Med. 2020 Jan 10;9(1):

Multiscale Selectivity and in vivo Biodistribution of NRP-1Targeted Theranostic AGuIX Nanoparticles for PDT of Glioblastoma.

Gries M, Thomas N, Daouk J, Rocchi P, Choulier L, Jubréaux J, Pierson J, Reinhard A, Jouan-Hureaux V, Chateau A, Acherar S, Frochot C, Lux F, Tillement O, Barberi-Heyob M

Int J Nanomedicine. 2020 ;15:8739-8758

New Targeted Gold Nanorods for the Treatment of Glioblastoma by Photodynamic Therapy.

Youssef Z, Yesmurzayeva N, Larue L, Jouan-Hureaux V, Colombeau L, Arnoux P, Acherar S, Vanderesse R, Frochot C

J Clin Med. 2019 Dec 13;8(12):

Fighting Hypoxia to Improve PDT.

Larue L, Myrzakhmetov B, Ben-Mihoub A, Moussaron A, Thomas N, Arnoux P, Baros F, Vanderesse R, Acherar S, Frochot C

Pharmaceuticals (Basel). 2019 Oct 30;12(4):

Synthesis and Anticancer Activity of Gold Porphyrin Linked to Malonate Diamine Platinum Complexes.

Toubia I, Nguyen C, Diring S, Ali LMA, Larue L, Aoun R, Frochot C, Gary-Bobo M, Kobeissi M, Odobel F

Inorg Chem. 2019 Sep 16;58(18):12395-12406

AGuIX from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine.

Lux F, Tran VL, Thomas E, Dufort S, Rossetti F, Martini M, Truillet C, Doussineau T, Bort G, Denat F, Boschetti F, Angelovski G, Detappe A, Crémillieux Y, Mignet N, Doan BT, Larrat B, Meriaux S, Barbier E, Roux S, Fries P, Müller A, Abadjian MC, Anderson C, Canet-Soulas E, Bouziotis P, Barberi-Heyob M, Frochot C, Verry C, Balosso J, Evans M, Sidi-Boumedine J, Janier M, Butterworth K, McMahon S, Prise K, Aloy MT, Ardail D, Rodriguez-Lafrasse C, Porcel E, Lacombe S, Berbeco R, Allouch A, Perfettini JL, Chargari C, Deutsch E, Le Duc G, Tillement O

Br J Radiol. 2018 Sep 18;:20180365

Use of Cyclodextrins in Anticancer Photodynamic Therapy Treatment.

Ben Mihoub A, Larue L, Moussaron A, Youssef Z, Colombeau L, Baros F, Frochot C, Vanderesse R, Acherar S

Molecules. 2018 Aug 2;23(8):

Using X-rays in photodynamic therapy: an overview.

Larue L, Ben Mihoub A, Youssef Z, Colombeau L, Acherar S, André JC, Arnoux P, Baros F, Vermandel M, Frochot C

Photochem. Photobiol. Sci.. 2018 Jun 25;:

Titania And Silica Nanoparticles Coupled To Chlorin e6 For Anti-Cancer Photodynamic Therapy.

Youssef Z, Jouan-Hureaux V, Colombeau L, Arnoux P, Moussaron A, Baros F, Toufaily J, Hamieh T, Roques-Carmes T, Frochot C

Photodiagnosis Photodyn Ther. 2018 Mar 23;:

New photodynamic molecular beacons (PMB) as potential cancer-targeted agents in PDT.

Stallivieri A, Colombeau L, Devy J, Etique N, Chaintreuil C, Myrzakhmetov B, Achard M, Baros F, Arnoux P, Vanderesse R, Frochot C

Bioorg. Med. Chem.. 2018 02 1;26(3):688-702

A Photosensitizer Lanthanide Nanoparticle Formulation that Induces Singlet Oxygen With Direct Light Excitation, But Not By Photon or X-ray Energy Transfer.

Chouikrat R, Baros F, André JC, Vanderesse R, Viana B, Bulin AL, Dujardin C, Arnoux P, Verelst M, Frochot C

Photochem. Photobiol.. 2017 Jun;:

Polymer-lipid-PEG hybrid nanoparticles as photosensitizer carrier for photodynamic therapy.

Pramual S, Lirdprapamongkol K, Svasti J, Bergkvist M, Jouan-Hureaux V, Arnoux P, Frochot C, Barberi-Heyob M, Niamsiri N

J. Photochem. Photobiol. B, Biol.. 2017 May;173:12-22

[Specific folic-acid targeted photosensitizer. The first step toward intraperitoneal photodynamic therapy for epithelial ovarian cancer].

Azaïs H, Frochot C, Grabarz A, Khodja Bach S, Colombeau L, Delhem N, Mordon S, Collinet P

Gynecol Obstet Fertil Senol. 2017 Mar;:

Extraction, Identification and Photo-Physical Characterization of Persimmon (Diospyros kaki L.) Carotenoids.

Zaghdoudi K, Ngomo O, Vanderesse R, Arnoux P, Myrzakhmetov B, Frochot C, Guiavarc'h Y

Foods. 2017 Jan;6(1):

Folic acid conjugates with photosensitizers for cancer targeting in photodynamic therapy: Synthesis and photophysical properties.

Stallivieri A, Colombeau L, Jetpisbayeva G, Moussaron A, Myrzakhmetov B, Arnoux P, Acherar S, Vanderesse R, Frochot C

Bioorg. Med. Chem.. 2017 Jan;25(1):1-10

Molecular modelling, synthesis and biological evaluation of peptide inhibitors as anti-angiogenic agent targeting neuropilin-1 for anticancer application.

Kamarulzaman EE, Vanderesse R, Gazzali AM, Barberi-Heyob M, Boura C, Frochot C, Shawkataly O, Aubry A, Wahab HA

J. Biomol. Struct. Dyn.. 2017 Jan;35(1):26-45

Proton MR Spectroscopy and Diffusion MR Imaging Monitoring to Predict Tumor Response to Interstitial Photodynamic Therapy for Glioblastoma.

Toussaint M, Pinel S, Auger F, Durieux N, Thomassin M, Thomas E, Moussaron A, Meng D, Plénat F, Amouroux M, Bastogne T, Frochot C, Tillement O, Lux F, Barberi-Heyob M

Theranostics. 2017 ;7(2):436-451

The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy.

Youssef Z, Vanderesse R, Colombeau L, Baros F, Roques-Carmes T, Frochot C, Wahab H, Toufaily J, Hamieh T, Acherar S, Gazzali AM

Cancer Nanotechnol. 2017 ;8(1):6

Ultrasmall AGuIX theranostic nanoparticles for vascular-targeted interstitial photodynamic therapy of glioblastoma.

Thomas E, Colombeau L, Gries M, Peterlini T, Mathieu C, Thomas N, Boura C, Frochot C, Vanderesse R, Lux F, Barberi-Heyob M, Tillement O

Int J Nanomedicine. 2017 ;12:7075-7088

Realtime Tracking of the Photobleaching Trajectory During Photodynamic Therapy.

Tylcz JB, Bastogne T, Bourguignon A, Frochot C, Barberi-Heyob M

IEEE Trans Biomed Eng. 2016 Oct;:

Realtime Tracking of the Photobleaching Trajectory During Photodynamic Therapy.

Tylcz JB, Bastogne T, Bourguignon A, Frochot C, Barberi-Heyob M

IEEE Trans Biomed Eng. 2016 Oct;:

Response surface methodology applied to Supercritical Fluid Extraction (SFE) of carotenoids from Persimmon (Diospyros kaki L.).

Zaghdoudi K, Framboisier X, Frochot C, Vanderesse R, Barth D, Kalthoum-Cherif J, Blanchard F, Guiavarc'h Y

Food Chem. 2016 Oct;208:209-19

Stability of folic acid under several parameters.

Gazzali AM, Lobry M, Colombeau L, Acherar S, Azaïs H, Mordon S, Arnoux P, Baros F, Vanderesse R, Frochot C

Eur J Pharm Sci. 2016 Oct;93:419-30

Assessment of the specificity of a new folate-targeted photosensitizer for peritoneal metastasis of epithelial ovarian cancer to enable intraperitoneal photodynamic therapy. A preclinical study.

Azaïs H, Schmitt C, Tardivel M, Kerdraon O, Stallivieri A, Frochot C, Betrouni N, Collinet P, Mordon S

Photodiagnosis Photodyn Ther. 2016 Mar;13:130-8

Inorganic Nanoparticles for Photodynamic Therapy.

Colombeau L, Acherar S, Baros F, Arnoux P, Gazzali AM, Zaghdoudi K, Toussaint M, Vanderesse R, Frochot C

Top Curr Chem. 2016 ;370:113-34

Accelerated solvent extraction of carotenoids from: Tunisian Kaki (Diospyros kaki L.), peach (Prunus persica L.) and apricot (Prunus armeniaca L.).

Zaghdoudi K, Pontvianne S, Framboisier X, Achard M, Kudaibergenova R, Ayadi-Trabelsi M, Kalthoum-Cherif J, Vanderesse R, Frochot C, Guiavarc'h Y

Food Chem. 2015 Oct 1;184:131-9

Fischer 344 Rat: A Preclinical Model for Epithelial Ovarian Cancer Folate-Targeted Therapy.

Azais H, Queniat G, Bonner C, Kerdraon O, Tardivel M, Jetpisbayeva G, Frochot C, Betrouni N, Collinet P, Mordon S

Int J Gynecol Cancer. 2015 Sep;25(7):1194-200

Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry.

Acherar S, Colombeau L, Frochot C, Vanderesse R

Curr Med Chem. 2015 Jul 16.

The interest of folic acid in targeted photodynamic therapy.

Stallivieri A, Baros F, Jetpisbayeva G, Myrzakhmetov B, Frochot C

Curr Med Chem. 2015 Jul 29.

Synthesis and photophysical properties of the photoactivatable cationic porphyrin 5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide for anti-malaria PDT.

Stallivieri A, Le Guern F, Vanderesse R, Meledje E, Jori G, Frochot C, Acherar S

Photochem Photobiol Sci. 2015 Jun 11.

Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI.

Bechet D, Auger F, Couleaud P, Marty E, Ravasi L, Durieux N, Bonnet C, Plenat F, Frochot C, Mordon S, Tillement O, Vanderesse R, Lux F, Perriat P, Guillemin F, Barberi-Heyob M

Nanomedicine. 2015 Jan 30. pii: S1549-9634(15)00013-1

Nanoparticles for Radiation Therapy Enhancement: the Key Parameters.

Retif P, Pinel S, Toussaint M, Frochot C, Chouikrat R, Bastogne T, Barberi-Heyob M

Theranostics. 2015 Jun 11;5(9):1030-44

New Peptide-Conjugated Chlorin-Type Photosensitizer Targeting Neuropilin-1 for Anti-Vascular Targeted Photodynamic Therapy.

Kamarulzaman EE, Gazzali AM, Acherar S, Frochot C, Barberi-Heyob M, Boura C, Chaimbault P, Sibille E, Wahab HA, Vanderesse R

Int J Mol Sci. 2015 Oct 12;16(10):24059-80

Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication.

Graindorge D, Martineau S, Machon C, Arnoux P, Guitton J, Francesconi S, Frochot C, Sage E, Girard PM

PLoS ONE. 2015 ;10(10):e0140645

Two-photon excitation of porphyrin-functionalized porous silicon nanoparticles for photodynamic therapy.

Secret E, Maynadier M, Gallud A, Chaix A, Bouffard E, Gary-Bobo M, Marcotte N, Mongin O, El Cheikh K, Hugues V, Auffan M, Frochot C, Morere A, Maillard P, Blanchard-Desce M, Sailor MJ, Garcia M, Durand JO, Cunin F

Adv Mater. 2014 Dec 3;26(45):7643-8

[FRalpha: a target for prophylactic photodynamic therapy of ovarian peritoneal metastasis?].

Azais H, Moussaron A, Khodja Bach S, Bassil A, Betrouni N, Frochot C, Collinet P, Mordon S

Bull Cancer. 2014 Dec;101(12):1109-13

A 5-(difluorenyl)-1,10-phenanthroline-based Ru(II) complex as a coating agent for potential multifunctional gold nanoparticles.

Moreau J, Lux F, Four M, Olesiak-Banska J, Matczyszyn K, Perriat P, Frochot C, Arnoux P, Tillement O, Samoc M, Ponterini G, Roux S, Lemercier G

Phys Chem Chem Phys. 2014 Jul 28;16(28):14826-33

Indocyanine Green: Photosensitizer or Chromophore? Still a Debate.

Giraudeau C, Moussaron A, Stallivieri A, Mordon S, Frochot C

Curr Med Chem. 2014 May;21(16):1871-97.

Manipulation and Optical Detection of Colloidal Functional Plasmonic Nanostructures in Microfluidic Systems.

Werts MHV, Allix F, Francais O, Frochot C, Griscom L, Le Pioufle B, Loumaigne M, Midelet J

Ieee J Sel Top Quantum Electron. 2014 May-jun;20(3):6900613.

Rational design of an arene ruthenium chlorin conjugate for in vivo anticancer activity.

Pernot M, Barry NPE, Bastogne T, Frochot C, Barberi-Heyob M, Therrien B

Inorg Chim Acta. 2014 Apr 1;414:134-40.

Preparation and characterization of mTHPC-loaded solid lipid nanoparticles for photodynamic therapy.

Navarro FP, Creusat G, Frochot C, Moussaron A, Verhille M, Vanderesse R, Thomann JS, Boisseau P, Texier I, Couffin AC, Barberi-Heyob M

J Photochem Photobiol B. 2014 Jan 5;130:161-9

Indocyanine Green: Photosensitizer or Chromophore ? Still a Debate.

Giraudeau C, Moussaron A, Stallivieri A, Mordon S, Frochot C

Curr Med Chem. 2013 Dec 17.

Lipophilic phthalocyanines for their potential interest in photodynamic therapy: synthesis and photo-physical properties.

Moussaron A, Arnoux P, Vanderesse R, Sibille E, Chaimbault P, Frochot C

Tetrahedron. 2013 Nov 25;69(47):10116-22.

X-ray-Induced Singlet Oxygen Activation with Nanoscintillator-Coupled Porphyrins.

Bulin AL, Truillett C, Chouikrat R, Lux F, Frochot C, Amans D, Ledoux G, Tillement O, Perriat P, Barberi-Heyob M, Dujardin C

J Phys Chem C. 2013 Oct 17;117(41):21583-9.

Bifunctional polypyridyl-Ru(II) complex grafted onto gadolinium-based nanoparticles for MR-imaging and photodynamic therapy.

Truillet C, Lux F, Moreau J, Four M, Sancey L, Chevreux S, Boeuf G, Perriat P, Frochot C, Antoine R, Dugourd P, Portefaix C, Hoeffel C, Barberi-Heyob M, Terryn C, van Gulick L, Lemercier G, Tillement O

Dalton Trans. 2013 Sep 14;42(34):12410-20

Non polymeric nanoparticles for photodynamic therapy applications: recent developments.

Chouikrat R, Seve A, Vanderesse R, Benachour H, Barberi-Heyob M, Richeter S, Raehm L, Durand JO, Verelst M, Frochot C

Mini Rev Med Chem. 2012 Sep 7.

Long-distance energy transfer photosensitizers arising in hybrid nanoparticles leading to fluorescence emission and singlet oxygen luminescence quenching.

Seve A, Couleaud P, Lux F, Tillement O, Arnoux P, Andre JC, Frochot C

Photochem Photobiol Sci. 2012 Feb 24.

Multifunctional Peptide-conjugated hybrid silica nanoparticles for photodynamic therapy and MRI.

Benachour H, Seve A, Bastogne T, Frochot C, Vanderesse R, Jasniewski J, Miladi I, Billotey C, Tillement O, Lux F, Barberi-Heyob M

Theranostics. 2012;2(9):889-904

Non polymeric nanoparticles for photodynamic therapy applications: recent developments.

Chouikrat R, Seve A, Vanderesse R, Benachour H, Barberi-Heyob M, Richeter S, Raehm L, Durand JO, Verelst M, Frochot C

Curr Med Chem. 2012;19(6):781-92.

Photodynamic molecular beacons triggered by MMP-2 and MMP-9: influence of the distance between photosensitizer and quencher onto photophysical properties and enzymatic activation.

Verhille M, Benachour H, Ibrahim A, Achard M, Arnoux P, Barberi-Heyob M, Andre JC, Allonas X, Baros F, Vanderesse R, Frochot C

Curr Med Chem. 2012;19(32):5580-94.

Real-time monitoring of photocytotoxicity in nanoparticles-based photodynamic therapy: a model-based approach.

Benachour H, Bastogne T, Toussaint M, Chemli Y, Seve A, Frochot C, Lux F, Tillement O, Vanderesse R, Barberi-Heyob M

PLoS One. 2012;7(11):e48617

Functionalized silica-based nanoparticles for photodynamic therapy.

Couleaud P, Bechet D, Vanderesse R, Barberi-Heyob M, Faure AC, Roux S, Tillement O, Porhel S, Guillemin F, Frochot C

Nanomedicine (Lond). 2011 Aug;6(6):995-1009

Stability of peptides and therapeutic success in cancer.

Pernot M, Vanderesse R, Frochot C, Guillemin F, Barberi-Heyob M

Expert Opin Drug Metab Toxicol. 2011 Jul;7(7):793-802

Quantum dot-folic acid conjugates as potential photosensitizers in photodynamic therapy of cancer.

Morosini V, Bastogne T, Frochot C, Schneider R, Francois A, Guillemin F, Barberi-Heyob M

Photochem Photobiol Sci. 2011 May;10(5):842-51

Triazinyl porphyrin-based photoactive cotton fabrics: preparation, characterization, and antibacterial activity.

Ringot C, Sol V, Barriere M, Saad N, Bressollier P, Granet R, Couleaud P, Frochot C, Krausz P

Biomacromolecules. 2011 May 9;12(5):1716-23

Silicalites and Mesoporous Silica Nanoparticles for photodynamic therapy.

Hocine O, Gary-Bobo M, Brevet D, Maynadier M, Fontanel S, Raehm L, Richeter S, Loock B, Couleaud P, Frochot C, Charnay C, Derrien G, Smaihi M, Sahmoune A, Morere A, Maillard P, Garcia M, Durand JO

Int J Pharm. 2010 Dec 15;402(1-2):221-30

Modulation of Photosensitization Processes for an Improved Targeted Photodynamic Therapy.

Verhille M, Couleaud P, Vanderesse R, Brault D, Barberi-Heyob M, Frochot C

Curr Med Chem. 2010;17(32):3925-43.

Aligned poly(L-lactic-co-e-caprolactone) electrospun microfibers and knitted structure: a novel composite scaffold for ligament tissue engineering.

Vaquette C, Kahn C, Frochot C, Nouvel C, Six JL, De Isla N, Luo LH, Cooper-White J, Rahouadj R, Wang X

J Biomed Mater Res A. 2010 Sep 15;94(4):1270-82.

Photodynamic therapy targeting neuropilin-1: Interest of pseudopeptides with improved stability properties.

Thomas N, Pernot M, Vanderesse R, Becuwe P, Kamarulzaman E, Da Silva D, Francois A, Frochot C, Guillemin F, Barberi-Heyob M

Biochem Pharmacol. 2010 Jul 15;80(2):226-35

Silica-based nanoparticles for photodynamic therapy applications.

Couleaud P, Morosini V, Frochot C, Richeter S, Raehm L, Durand JO

Nanoscale. 2010 Jul 7;2(7):1083-95

Neuropilin-1 targeting photosensitization-induced early stages of thrombosis via tissue factor release.

Bechet D, Tirand L, Faivre B, Plenat F, Bonnet C, Bastogne T, Frochot C, Guillemin F, Barberi-Heyob M

Pharm Res. 2010 Mar;27(3):468-79

Response surface methodology: an extensive potential to optimize in vivo photodynamic therapy conditions.

Tirand L, Bastogne T, Bechet D, Linder M, Thomas N, Frochot C, Guillemin F, Barberi-Heyob M

Int J Radiat Oncol Biol Phys. 2009 Sep 1;75(1):244-52

Peptide-conjugated chlorin-type photosensitizer binds neuropilin-1 in vitro and in vivo.

Thomas N, Bechet D, Becuwe P, Tirand L, Vanderesse R, Frochot C, Guillemin F, Barberi-Heyob M

J Photochem Photobiol B. 2009 Aug 3;96(2):101-8

Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy.

Brevet D, Gary-Bobo M, Raehm L, Richeter S, Hocine O, Amro K, Loock B, Couleaud P, Frochot C, Morere A, Maillard P, Garcia M, Durand JO

Chem Commun (Camb). 2009 Mar 28;(12):1475-7

Multistate photo-induced relaxation and photoisomerization ability of fumaramide threads: a computational and experimental study.

Altoe P, Haraszkiewicz N, Gatti FG, Wiering PG, Frochot C, Brouwer AM, Balkowski G, Shaw D, Woutersen S, Buma WJ, Zerbetto F, Orlandi G, Leigh DA, Garavelli M

J Am Chem Soc. 2009 Jan 14;131(1):104-17.

Nanoparticles as vehicles for delivery of photodynamic therapy agents

Bechet D, Couleaud P, Frochot C, Viriot ML, Guillemin F, Barberi-Heyob M

Trends Biotechnol. 2008 Nov;26(11):612-21

An innovative method to obtain porous PLLA scaffolds with highly spherical and interconnected pores.

Vaquette C, Frochot C, Rahouadj R, Wang X

J Biomed Mater Res B Appl Biomater. 2008 Jul;86(1):9-17.

Improvement of meta-tetra(hydroxyphenyl)chlorin-like photosensitizer selectivity with folate-based targeted delivery. synthesis and in vivo delivery studies.

Gravier J, Schneider R, Frochot C, Bastogne T, Schmitt F, Didelon J, Guillemin F, Barberi-Heyob M

J Med Chem. 2008 Jul 10;51(13):3867-77

Changes in humic acid conformation during coagulation with ferric chloride: implications for drinking water treatment.

Sieliechi JM, Lartiges BS, Kayem GJ, Hupont S, Frochot C, Thieme J, Ghanbaja J, d'Espinose de la Caillerie JB, Barres O, Kamga R, Levitz P, Michot LJ

Water Res. 2008 Apr;42(8-9):2111-23

Tissue distribution and pharmacokinetics of an ATWLPPR-conjugated chlorin-type photosensitizer targeting neuropilin-1 in glioma-bearing nude mice.

Thomas N, Tirand L, Chatelut E, Plenat F, Frochot C, Dodeller M, Guillemin F, Barberi-Heyob M

Photochem Photobiol Sci. 2008 Apr;7(4):433-41

Influence of the gelator structure and solvent on the organisation and chirality of self-assembling fibrillar networks

Pham QN, Brosse N, Frochot C, Dumas D, Hocquet A, Jamart-Gregoire B

New J Chem. 2008;32(7):1131-9

Interest of RGD-containing linear or cyclic peptide targeted tetraphenylchlorin as novel photosensitizers for selective photodynamic activity.

Frochot C, Di Stasio B, Vanderesse R, Belgy MJ, Dodeller M, Guillemin F, Viriot ML, Barberi-Heyob M

Bioorg Chem. 2007 Jun;35(3):205-20

Metabolic profile of a peptide-conjugated chlorin-type photosensitizer targeting neuropilin-1: an in vivo and in vitro study.

Tirand L, Thomas N, Dodeller M, Dumas D, Frochot C, Maunit B, Guillemin F, Barberi-Heyob M

Drug Metab Dispos. 2007 May;35(5):806-13

The photodynamic therapy

Barberi-Heyob M, Frochot C, Bezdetnaya-Bolotine L, Brault D, Dumas D, Guillemin F, Krausz P, Maillard P, Maunit B, Merlin JL, Mordon S, Muller JF, Patrice T, Simonneaux G, Tanielian C

Actual Chim. 2007 May-jun;:26-34

Divergent synthesis of novel unsymmetrical dendrons containing photosensitizing units.

Morosini V, Frochot C, Barberi-Heyob M, Schneider R

Tetrahedron Lett. 2006 Dec 4;47(49):8745-9.

Recent improvements in the use of synthetic peptides for a selective photodynamic therapy.

Schneider R, Tirand L, Frochot C, Vanderesse R, Thomas N, Gravier J, Guillemin F, Barberi-Heyob M

Anticancer Agents Med Chem. 2006 Sep;6(5):469-88.

Fate of coagulant species and conformational effects during the aggregation of a model of a humic substance with Al13 polycations.

Kazpard V, Lartiges BS, Frochot C, d'Espinose de la Caillerie JB, Viriot ML, Portal JM, Gorner T, Bersillon JL

Water Res. 2006 Jun;40(10):1965-74

A peptide competing with VEGF165 binding on neuropilin-1 mediates targeting of a chlorin-type photosensitizer and potentiates its photodynamic activity in human endothelial cells.

Tirand L, Frochot C, Vanderesse R, Thomas N, Trinquet E, Pinel S, Viriot ML, Guillemin F, Barberi-Heyob M

J Control Release. 2006 Mar 10;111(1-2):153-64

In vitro biocompatibility of different polyester membranes.

Vaquette C, Fawzi-Grancher S, Lavalle P, Frochot C, Viriot ML, Muller S, Wang X

Biomed Mater Eng. 2006;16(4 Suppl):S131-6.

The 2-aminoglucosamide motif improves cellular uptake and photodynamic activity of tetraphenylporphyrin.

Di Stasio B, Frochot C, Dumas D, Even P, Zwier J, Muller A, Didelon J, Guillemin F, Viriot ML, Barberi-Heyob M

Eur J Med Chem. 2005 Nov;40(11):1111-22

Design, synthesis, and biological evaluation of folic acid targeted tetraphenylporphyrin as novel photosensitizers for selective photodynamic therapy.

Schneider R, Schmitt F, Frochot C, Fort Y, Lourette N, Guillemin F, Muller JF, Barberi-Heyob M

Bioorg Med Chem. 2005 Apr 15;13(8):2799-808.

Synthesis of amino-phenolic humic-like substances and comparison with natural aquatic humic acids: A multi-analytical techniques approach.

Jung AV, Frochot C, Parant S, Lartiges BS, Selve C, Viriot ML, Bersillon JL

Org Geochem. 2005;36(9):1252-71.

New glycosylated porphyrins for PDT applications.

Frochot C, Di Stasio B, Barberi-Heyob M, Carre MC, Zwier JM, Guillemin F, Viriot ML

Oftalmologia. 2003 ;56(1):62-6

Specific fluorescent tracers. Imaging and applications for photodynamic therapy.

Teiten MH, Even P, Burgos P, Frochot C, Aubert S, Carré MC, Bolotine L, Merlin JL, Guillemin F, Viriot ML

C. R. Biol.. 2002 Apr;325(4):487-93

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