Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an ambulatory elderly population.
Fiche publication
Date publication
février 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis
Tous les auteurs :
Gueant-Rodriguez RM, Spada R, Moreno-Garcia M, Anello G, Bosco P, Lagrost L, Romano A, Elia M, Gueant JL
Lien Pubmed
Résumé
OBJECTIVE: The ankle brachial index (ABI) is an indicator of lower extremity peripheral arterial disease (PAD) and a predictor of atherothrombosis. ApoA-I and HDL are associated with PAD, in humans. Homocysteine influences the liver expression of ApoA-I and decreases its blood level and HDL in genetic mice models. We aimed therefore to evaluate whether homocysteine and its nutritional determinants, folate and vitamin B12 are associated with ABI by influencing HDL metabolism, in an ambulatory elderly population. METHODS: 667 elderly volunteers from rural Sicily were assessed for ABI, homocysteine and its determinants, lipid markers and other predictors of PAD. HDL size was assessed in 15 sera in upper and lower quartiles of Hcy distribution. RESULTS: In multivariate analysis, ApoA-I and homocysteine were two predictors of ABI (beta-coefficient = 2.86, P
Référence
Atherosclerosis. 2011 Feb;214(2):480-5