Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
Fiche publication
Date publication
novembre 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis
Tous les auteurs :
Cornejo-Garcia JA, Liou LB, Blanca-Lopez N, Dona I, Chen CH, Chou YC, Chuang HP, Wu JY, Chen YT, Plaza-Seron Mdel C, Mayorga C, Gueant-Rodriguez RM, Lin SC, Torres MJ, Campo P, Rondon C, Laguna JJ, Fernandez J, Gueant JL, Canto G, Blanca M, Lee MT
Lien Pubmed
Résumé
AIM: Acute urticaria/angioedema (AUA) induced by cross-intolerance to NSAIDs is the most frequent clinical entity in hypersensitivity reactions to drugs. In this work, we conducted a genome-wide association study in Spanish and Han Chinese patients suffering from NSAID-induced AUA. MATERIALS & METHODS: A whole-genome scan was performed on a total of 232 cases (112 Spanish and 120 Han Chinese) with NSAID-induced AUA and 225 unrelated controls (124 Spanish and 101 Han Chinese). RESULTS: Although no polymorphism reached genome-wide significance, we obtained suggestive associations for three clusters in the Spanish group (RIMS1, BICC1 and RAD51L 1) and one region in the Han Chinese population (ABI3BP). Five regions showed suggestive associations after meta-analysis: HLF, RAD51L1, COL24A1, GalNAc-T13 and FBXL7. A majority of these genes are related to Ca(2+), cAMP and/or P53 signaling pathways. CONCLUSION: The associations described were different from those related to the metabolism of arachidonic acid and could provide new mechanisms underlying NSAID-induced AUA.
Référence
Pharmacogenomics. 2013 Nov;14(15):1857-69