Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency.

Fiche publication


Date publication

décembre 2021

Journal

Clinical epigenetics

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina, Pr GUEANT Jean-Louis, Dr OUSSALAH Abderrahim


Tous les auteurs :
Siblini Y, Chéry C, Rouyer P, Raso J, Julien A, Hergalant S, François A, Bezdetnaya L, Vogin G, Guéant JL, Oussalah A

Résumé

Although radiation therapy represents a core cancer treatment modality, its efficacy is hampered by radioresistance. The effect of ionizing radiations (IRs) is well known regarding their ability to induce genetic alterations; however, their impact on the epigenome landscape in cancer, notably at the CpG dinucleotide resolution, remains to be further deciphered. In addition, no evidence is available regarding the effect of IRs on the DNA methylome profile according to the methionine dependency phenotype, which represents a hallmark of metabolic adaptation in cancer.

Mots clés

Aberrant methylation, Epigenome alterations, Epigenome-wide association study, Glioblastoma, Hepatocellular carcinoma, Ionizing radiation, Melanoma, Metabolic adaptation in cancer, Methionine dependency, Radiation therapy, Radioresistance

Référence

Clin Epigenetics. 2021 Dec 1;13(1):212