Follicular helper-T cells restore CD8-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy.

Fiche publication


Date publication

juin 2021

Journal

Journal for immunotherapy of cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François, Mme TRUNTZER Caroline, Dr VEGRAN Frédérique, Dr REBE Cédric, Dr CHALMIN Fanny, Dr DERANGERE Valentin, Dr THIBAUDIN Marion


Tous les auteurs :
Niogret J, Berger H, Rebe C, Mary R, Ballot E, Truntzer C, Thibaudin M, Derangère V, Hibos C, Hampe L, Rageot D, Accogli T, Joubert P, Routy B, Harker J, Vegran F, Ghiringhelli F, Chalmin F

Résumé

T follicular helper cells (Tfh) are essential to shape B cell response during germinal center formation. Tfh accumulation has been reported in various human cancers, with positive or negative prognostic roles. However, the mechanisms explaining the accumulation of Tfh and their role in cancer remain obscure.

Mots clés

CD8-positive T-lymphocytes, immunotherapy, programmed cell death 1 receptor

Référence

J Immunother Cancer. 2021 Jun;9(6):