Post-Essential Thrombocythemia Myelofibrosis and Multiple Isodicentric Y Chromosomes: A Unique Case among a Rare Association.
Fiche publication
Date publication
février 2020
Journal
Cytogenetic and genome research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FERRAND Christophe, Dr COLLONGE-RAME Marie-Agnès
Tous les auteurs :
Dahlen E, Sarghi SI, Renosi F, Ferrand C, Collonge-Rame MA, Kuentz P
Lien Pubmed
Résumé
Multiple isodicentric Y chromosomes [idic(Y)] is a rare cytogenetic abnormality, most exclusively described in constitutional karyotypes. Only recently has this entity been reported in hematologic neoplasms such as myeloid disorders, albeit these cases remain very scarce. The possible involvement of increasing copies of potential proto-oncogenes located on the multiple idic(Y) led to consider one of them, CRLF2, as a target for kinase inhibitors. We report here, to our knowledge, the first case of multiple idic(Y) in a patient with myelofibrosis secondary to essential thrombocythemia. The patient received ruxolitinib therapy with initial good clinical response.
Mots clés
Référence
Cytogenet. Genome Res.. 2020 Feb 1;: