Familial hematological malignancies: ASXL1 gene investigation.
Fiche publication
Date publication
avril 2016
Journal
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FAIVRE Laurence
Tous les auteurs :
Hamadou WS, Abed RE, Besbes S, Bourdon V, Fabre A, Youssef YB, Laatiri MA, Eisinger F, Mari V, Gesta P, Dreyfus H, Bonadona V, Dugast C, Zattara H, Faivre L, Jemni SY, Noguchi T, Khélif A, Sobol H, Soua Z
Lien Pubmed
Résumé
Familial aggregation among patients with several hematological malignancies has been revealed. This emphasizes the importance of genetic factors. Only few genes predisposing to familial hematological malignancies have been reported until now due to the low occurrence. We have described in previous study PRF1 and CEBPA variants that might contribute to the background of genetic factors, which encourage us to extend our investigations to other cooperating genes. The aim of this study is to determine whether germline additional sex combs-like 1 (ASXL1) gene mutations may be involved?
Mots clés
Adult, Amino Acid Sequence, Biomarkers, Tumor, genetics, DNA Mutational Analysis, Female, Follow-Up Studies, Genetic Predisposition to Disease, Germ-Line Mutation, genetics, Hematologic Neoplasms, diagnosis, Humans, Male, Mutation, Missense, genetics, Neoplasm Staging, Pedigree, Prognosis, Repressor Proteins, genetics, Sequence Homology, Amino Acid
Référence
Clin Transl Oncol. 2016 Apr;18(4):385-90