Systemic high-dose intravenous methotrexate in patients with central nervous system metastatic breast cancer.
Fiche publication
Date publication
novembre 2019
Journal
BMC cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CHAIGNEAU Loïc, Pr PIVOT Xavier, Dr ROYER Bernard, Dr CURTIT Elsa, Dr MANSI Laura
Tous les auteurs :
Bazan F, Dobi E, Royer B, Curtit E, Mansi L, Menneveau N, Paillard MJ, Meynard G, Villanueva C, Pivot X, Chaigneau L
Lien Pubmed
Résumé
Infusion of high-dose intravenous methotrexate (MTX) has been demonstrating to penetrate the blood-brain barrier. The aim of this present study was to assess the efficacy and safety of high dose MTX in patients with central nervous system (CNS) metastases of breast cancer.
Mots clés
Breast, Central nervous system, Chemotherapy, Methotrexate
Référence
BMC Cancer. 2019 Nov 1;19(1):1029