Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression.
Fiche publication
Date publication
août 2017
Journal
Journal of the National Cancer Institute
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DAVIDSON Irwin
Tous les auteurs :
Bonet C, Luciani F, Ottavi JF, Leclerc J, Jouenne FM, Boncompagni M, Bille K, Hofman V, Bossis G, Marco de Donatis G, Strub T, Cheli Y, Ohanna M, Luciano F, Marchetti S, Rocchi S, Birling MC, Avril MF, Poulalhon N, Luc T, Hofman P, Lacour JP, Davidson I, Bressac-de Paillerets B, Ballotti R, Marine JC, Bertolotto C
Lien Pubmed
Résumé
MITF encodes an oncogenic lineage-specific transcription factor in which a germline mutation ( MITFE318K ) was identified in human patients predisposed to both nevus formation and, among other tumor types, melanoma. The molecular mechanisms underlying the oncogenic activity of MITF E318K remained uncharacterized.
Mots clés
Adult, Aged, Animals, Cell Line, Tumor, Cellular Senescence, genetics, Disease Models, Animal, Germ-Line Mutation, Humans, Melanocytes, Melanoma, genetics, Mice, Microphthalmia-Associated Transcription Factor, genetics, Middle Aged, Nevus, genetics, PTEN Phosphohydrolase, genetics, Primary Cell Culture, Proto-Oncogene Proteins B-raf, genetics, Skin Neoplasms, genetics, Sumoylation, Transcriptome
Référence
J. Natl. Cancer Inst.. 2017 08 1;109(8):