Enrolling study personnel in Ebola vaccine trials: from guidelines to practice in a non-epidemic context.
Fiche publication
Date publication
juillet 2019
Journal
Trials
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DABAKUYO-YONLI Sandrine
Tous les auteurs :
Lhomme E, Modet C, Augier A, Faye S, Dabakuyo-Yonli TS, Levy-Marchal C, D'Ortenzio E, Yazdanpanah Y, Chêne G, Beavogui AH, Richert L,
Lien Pubmed
Résumé
Enrolling participants in clinical trials can be challenging, especially with respect to prophylactic vaccine trials. The vaccination of study personnel in Ebola vaccine trials during the 2014-2016 epidemic played a crucial role in inspiring trust and facilitating volunteer enrollment. We evaluated the ethical and methodological considerations as they applied to an ongoing phase 2 randomized prophylactic Ebola vaccine trial that enrolled healthy volunteers in Guinea, Liberia, Sierra Leone, and Mali in a non-epidemic context.
Mots clés
Clinical trials, Ebola vaccine, Employees, Ethics, Health workers, Low- and middle-income countries, Research participants, Site staff, Trial participants
Référence
Trials. 2019 Jul 11;20(1):422