Toxicity of oxaliplatin plus fluorouracil/leucovorin adjuvant chemotherapy in elderly patients with stage III colon cancer: a population-based study.

Fiche publication


Date publication

août 2014

Journal

Annals of surgical oncology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BEDENNE Laurent, Dr BOUVIER Anne-Marie, Pr LEPAGE Côme


Tous les auteurs :
Hamza S, Bouvier AM, Rollot F, Lepage C, Faivre J, Bedenne L

Résumé

Results concerning the side effects of oxaliplatin associated with fluorouracil and leucovorin (FOLFOX) in older patients are controversial. The objective of this study was to assess the use and the toxicity of FOLFOX in patients aged 70 years and older as administered in current practice.

Mots clés

Adenocarcinoma, drug therapy, Aged, Antineoplastic Combined Chemotherapy Protocols, adverse effects, Cohort Studies, Colonic Neoplasms, drug therapy, Digestive System Diseases, chemically induced, Female, Fluorouracil, administration & dosage, Follow-Up Studies, France, epidemiology, Hematologic Diseases, chemically induced, Humans, Incidence, Leucovorin, administration & dosage, Male, Neoplasm Staging, Nervous System Diseases, chemically induced, Organoplatinum Compounds, administration & dosage, Prognosis, Survival Rate

Référence

Ann. Surg. Oncol.. 2014 Aug;21(8):2636-41