Regulation of T cell antitumor immune response by tumor induced metabolic stress.
Fiche publication
Date publication
novembre 2018
Journal
Cell stress
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François, Dr VEGRAN Frédérique, Dr BRUCHARD Mélanie, Dr CHALMIN Fanny
Tous les auteurs :
Chalmin F, Bruchard M, Vegran F, Ghiringhelli F
Lien Pubmed
Résumé
Adaptive T cell immune response is essential for tumor growth control. The efficacy of immune checkpoint inhibitors is regulated by intratumoral immune response. The tumor microenvironment has a major role in adaptive immune response tuning. Tumor cells generate a particular metabolic environment in comparison to other tissues. Tumors are characterized by glycolysis, hypoxia, acidosis, amino acid depletion and fatty acid metabolism modification. Such metabolic changes promote tumor growth, impair immune response and lead to resistance to therapies. This review will detail how these modifications strongly affect CD8 and CD4 T cell functions and impact immunotherapy efficacy.
Mots clés
T cells, acidosis, amino acids, antitumor immmunity, fatty acid, hypoxia, metabolic stress
Référence
Cell Stress. 2018 Nov 27;3(1):9-18