RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer.
Fiche publication
Date publication
novembre 2018
Journal
Journal for immunotherapy of cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ARNOULD Laurent, Dr BOIDOT Romain, Pr GHIRINGHELLI François, Dr LADOIRE Sylvain, Mme TRUNTZER Caroline, Dr VINCENT Julie, Dr BENGRINE-LEFEVRE Leila, Dr DERANGERE Valentin
Tous les auteurs :
Ledys F, Klopfenstein Q, Truntzer C, Arnould L, Vincent J, Bengrine L, Remark R, Boidot R, Ladoire S, Ghiringhelli F, Derangere V
Lien Pubmed
Résumé
T lymphocytes and HLA expression on tumor cell both influence prognostic of localized colorectal cancer, but their role following chemotherapy in patients with liver metastatic colorectal cancer (mCRC) was not addressed.
Mots clés
CD8, Colorectal cancer, HLA, Liver metastases
Référence
J Immunother Cancer. 2018 Nov 19;6(1):123