Clinical and molecular characterisation of hereditary and sporadic metastatic colorectal cancers harbouring microsatellite instability/DNA mismatch repair deficiency.
Fiche publication
Date publication
novembre 2017
Journal
European journal of cancer (Oxford, England : 1990)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VERNEREY Dewi, Pr BIBEAU Frédéric
Tous les auteurs :
Cohen R, Buhard O, Cervera P, Hain E, Dumont S, Bardier A, Bachet JB, Gornet JM, Lopez-Trabada D, Dumont S, Kaci R, Bertheau P, Renaud F, Bibeau F, Parc Y, Vernerey D, Duval A, Svrcek M, André T
Lien Pubmed
Résumé
Patients treated with chemotherapy for microsatellite unstable (MSI) and/or mismatch repair deficient (dMMR) cancer metastatic colorectal cancer (mCRC) exhibit poor prognosis. We aimed to evaluate the relevance of distinguishing sporadic from Lynch syndrome (LS)-like mCRCs.
Mots clés
Adult, Aged, Biomarkers, Tumor, genetics, Colorectal Neoplasms, genetics, Colorectal Neoplasms, Hereditary Nonpolyposis, genetics, DNA Methylation, DNA Mismatch Repair, Diagnosis, Differential, Disease-Free Survival, Female, France, Genetic Predisposition to Disease, Heredity, Humans, Kaplan-Meier Estimate, Male, Microsatellite Instability, Middle Aged, Molecular Diagnostic Techniques, Multivariate Analysis, MutL Protein Homolog 1, genetics, Mutation, Neoplasm Metastasis, Pedigree, Phenotype, Predictive Value of Tests, Proportional Hazards Models, Proto-Oncogene Proteins B-raf, genetics, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome
Référence
Eur. J. Cancer. 2017 11;86:266-274