LPCAT2 controls chemoresistance in colorectal cancer.
Fiche publication
Date publication
janvier 2018
Journal
Molecular & cellular oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DELMAS Dominique, Pr GHIRINGHELLI François, Dr AIRES Virginie
Tous les auteurs :
Cotte AK, Aires V, Ghiringhelli F, Delmas D
Lien Pubmed
Résumé
Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation.
Mots clés
LPCAT2, Lipid droplets, chemoresistance, colorectal cancer, immunogenic cell death
Référence
Mol Cell Oncol. 2018 ;5(3):e1448245