Epidemiology and prognosis of synchronous and metachronous colon cancer metastases: a French population-based study.
Fiche publication
Date publication
septembre 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BOUVIER Anne-Marie, Pr GHIRINGHELLI François, Pr LEPAGE Côme, Dr HENNEQUIN Audrey
Tous les auteurs :
Ghiringhelli F, Hennequin A, Drouillard A, Lepage C, Faivre J, Bouvier AM
Lien Pubmed
Résumé
BACKGROUND: Epidemiological data on synchronous and metachronous metastatic colon cancer are scarce. We assessed epidemiological characteristics and survival in synchronous and metachronous metastatic colon cancer in a French population. METHODS: Our study included 932 cases of metastatic colon cancer diagnosed in 1999-2010 and registered in a population-based cancer registry; 758 were synchronous colon metastases and 174 metachronous metastases from resected primary colon cancers diagnosed in 1999-2005. Univariate relative survival was calculated and a multivariate model with proportional hazard applied to net survival by interval was used. RESULTS: Mean age at diagnosis was 71.1 years for patients with metachronous metastasis and 71.4 years for those with synchronous metastasis (p=0.818). Patients with metachronous metastasis were more likely to have R0 resection (Odds Ratio: 3.05 [1.96-4.76], p
Référence
Dig Liver Dis. 2014 Sep;46(9):854-8