Nanovectorization of DNA Through Cells Using Protamine Complexation.
Fiche publication
Date publication
août 2016
Journal
The Journal of membrane biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BORG Christophe, Pr DELAGE-MOURROUX Régis, Dr HERVOUET Eric, Dr PICAUD Fabien, Pr BOULAHDOUR Hatem
Tous les auteurs :
Boukari K, Caoduro C, Kacem R, Skandrani N, Borg C, Boulahdour H, Gharbi T, Delage-Mourroux R, Hervouet E, Pudlo M, Picaud F
Lien Pubmed
Résumé
Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine-DNA-CNT complex.
Mots clés
Nanovectorization, Protamine, Simulation
Référence
J. Membr. Biol.. 2016 Aug;249(4):493-501