Dr PICAUD Fabien

Fiche personne

Coordonnées

Laboratoire SINERGiES - UR4662
16 route de Gray
25030 BESANCON Cedex

03 81 66 62 84

fabien.picaud@univ-fcomte.fr

Territoire

Franche-Comté

Statut

Enseignant-Chercheur

Affiliation

Université Marie & Louis Pasteur (UMLP (ex-UFC))

Laboratoire SINERGiES "Soins intégrés, nanomédecine, IA, & ingénierie pour la santé" - UR 4662 (SINERGiES)

Équipes/plateformes

SINERGiES UR 4662 - Equipe "Ingénierie pour la santé"

Mésocentre de calculs de Franche-Comté

Recherche

Mots clés : Nanovectorisation, nanomédecine, biomimétisme et applications

Publications

Highly potent antiviral drug candidates targeting SARS-CoV-2 nsp3 and nsp5.

Galais M, Herlem G, Haidar Ahmad S, Dutilleul A, Pasquereau S, El Baba R, Bellefroid M, Plant E, Morot-Bizot S, Picaud F, Herbein G, Van Lint C

Biomed Pharmacother. 2026 08 4;202:119753

Effect of pyrimethanil on aβ42 aggregation mechanisms revealed at single entity level and molecular dynamic simulations.

Meyer N, Arroyo N, Roustan L, Janot JM, Perrier V, Torrent J, Picaud F, Balme S

Biophys Chem. 2025 05 31;325:107471

Secondary Nucleation of Aβ Revealed by Single-Molecule and Computational Approaches.

Meyer N, Arroyo N, Roustan L, Janot JM, Charles-Achille S, Torrent J, Picaud F, Balme S

Adv Sci (Weinh). 2024 08 19;:e2404916

Direct Defluorination and Amination of Polytetrafluoroethylene and Other Fluoropolymers by Lithium Alkylamides.

Herlem G, Roina Y, Fregnaux M, Gonçalves AM, Cattey H, Picaud F, Auber F

Molecules. 2024 06 26;29(13):

Impact of Single-Walled Carbon Nanotube Functionalization on Ion and Water Molecule Transport at the Nanoscale.

Mejri A, Arroyo N, Herlem G, Palmeri J, Manghi M, Henn F, Picaud F

Nanomaterials (Basel). 2024 01 3;14(1):

Translocation Processes of Pt(II)-Based Drugs through Human Breast Cancer Cell Membrane: Experiments.

Almeida ER, Goliatt PVZC, Dos Santos HF, Picaud F

J Chem Inf Model. 2023 09 26;:

Modeling the Cellular Uptake of Functionalized Carbon Nanohorns Loaded with Cisplatin through a Breast Cancer Cell Membrane.

Almeida ER, Goliatt PVZC, Dos Santos HF, Picaud F

Mol Pharm. 2023 08 30;:

Ultrasensitive Detection of Aβ42 Seeds in Cerebrospinal Fluid with a Nanopipette-Based Real-Time Fast Amyloid Seeding and Translocation Assay.

Meyer N, Bentin J, Janot JM, Abrao-Nemeir I, Charles-Achille S, Pratlong M, Aquilina A, Trinquet E, Perrier V, Picaud F, Torrent J, Balme S

Anal Chem. 2023 08 16;:

Investigation of α-synuclein and Amyloid-β(42)-E22 Δ oligomers using SiN nanopore functionalized with L-dopa.

Abrao-Nemeir I, Bentin J, Meyer N, Janot JM, Torrent J, Picaud F, Balme S

Chem Asian J. 2022 08 29;:

Nanovectorization of Ivermectin to avoid overdose of drugs.

Duverger E, Herlem G, Picaud F

J Biomol Struct Dyn. 2022 Apr 26;:1-14

Conical nanopores highlight the pro-aggregating effects of pyrimethanil fungicide on Aβ(1-42) peptides and dimeric splitting phenomena.

Meyer N, Arroyo N, Baldelli M, Coquart N, Janot JM, Perrier V, Chinappi M, Picaud F, Torrent J, Balme S

Chemosphere. 2022 Mar;291(Pt 1):132733

Detection of Amyloid-β Fibrils Using Track-Etched Nanopores: Effect of Geometry and Crowding.

Meyer N, Arroyo N, Janot JM, Lepoitevin M, Stevenson A, Nemeir IA, Perrier V, Bougard D, Belondrade M, Cot D, Bentin J, Picaud F, Torrent J, Balme S

ACS Sens. 2021 10 22;6(10):3733-3743

A potential solution to avoid overdose of mixed drugs in the event of Covid-19: Nanomedicine at the heart of the Covid-19 pandemic.

Duverger E, Herlem G, Picaud F

J Mol Graph Model. 2021 05;104:107834

Impact of surface state on polyethylene glycol conformation confined inside a nanopore.

Arroyo N, Balme S, Picaud F

J Chem Phys. 2021 Mar 14;154(10):104901

Breaking the Controversy of the Electropolymerization of Pyrrole Mechanisms by the Effective Screening Medium Quantum Charged Model Interface.

Herlem G, Picaud F

J Phys Chem A. 2021 Mar 11;125(9):1860-1869

From Behavior of Water on Hydrophobic Graphene Surfaces to Ultra-Confinement of Water in Carbon Nanotubes.

Mejri A, Herlem G, Picaud F

Nanomaterials (Basel). 2021 Jan 25;11(2):

Conformation of Polyethylene Glycol inside Confined Space: Simulation and Experimental Approaches.

Ma T, Arroyo N, Marc Janot J, Picaud F, Balme S

Nanomaterials (Basel). 2021 Jan 19;11(1):

Theoretical study of ciprofloxacin antibiotic trapping on graphene or boron nitride oxide nanoflakes.

Duverger E, Picaud F

J Mol Model. 2020 May 13;26(6):135

Polynucleotide differentiation using hybrid solid-state nanopore functionalizing with α-hemolysin.

Bentin J, Balme S, Picaud F

Soft Matter. 2020 Jan 28;16(4):1002-1010

Ligand nanovectorization using graphene to target cellular death receptors of cancer cell.

Arroyo N, Herlem G, Picaud F

Proteins. 2020 01;88(1):94-105

From Anodic Oxidation of Aliphatic α-Amino Acids to Polypeptides by Quantum Electrochemistry Approach: Beyond Miller-Urey Experiments.

Herlem G, Alhedabi T, Picaud F

J Am Chem Soc. 2019 09 11;141(36):14230-14238

Influence of nanotube section on carboplatin confinement.

Bentin J, Duverger E, Picaud F

J Mol Model. 2019 Feb 21;25(3):72

Unexpected ionic transport behavior in hydrophobic and uncharged conical nanopores.

Balme S, Picaud F, Lepoitevin M, Bechelany M, Balanzat E, Janot JM

Faraday Discuss. 2018 10 1;210:69-85

The encapsulation of the gemcitabine anticancer drug into grapheme nest: a theoretical study.

Mlaouah M, Tangour B, El Khalifi M, Gharbi T, Picaud F

J Mol Model. 2018 Mar 22;24(4):102

Simulations of a Graphene Nanoflake as a Nanovector To Improve ZnPc Phototherapy Toxicity: From Vacuum to Cell Membrane.

Duverger E, Picaud F, Stauffer L, Sonnet P

ACS Appl Mater Interfaces. 2017 Nov 1;9(43):37554-37562

Controlling activation barrier by carbon nanotubes as nano-chemical reactors.

Méjri A, Picaud F, El Khalifi M, Gharbi T, Tangour B

J Mol Model. 2017 Aug;23(8):229

Boron Nitride Nanoporous Membranes with High Surface Charge by Atomic Layer Deposition.

Weber M, Koonkaew B, Balme S, Utke I, Picaud F, Iatsunskyi I, Coy E, Miele P, Bechelany M

ACS Appl Mater Interfaces. 2017 May 17;9(19):16669-16678

TRAIL-NP hybrids for cancer therapy: a review.

Belkahla H, Herlem G, Picaud F, Gharbi T, Hémadi M, Ammar S, Micheau O

Nanoscale. 2017 Apr;:

N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.

Dufour F, Rattier T, Shirley S, Picarda G, Constantinescu AA, Morlé A, Zakaria AB, Marcion G, Causse S, Szegezdi E, Zajonc DM, Seigneuric R, Guichard G, Gharbi T, Picaud F, Herlem G, Garrido C, Schneider P, Benedict CA, Micheau O

Cell Death Differ.. 2017 Mar;24(3):500-510

Encapsulation capacity and natural payload delivery of an anticancer drug from boron nitride nanotube.

El Khalifi M, Bentin J, Duverger E, Gharbi T, Boulahdour H, Picaud F

Phys Chem Chem Phys. 2016 Sep 14;18(36):24994-25001

Enhanced DR5 binding capacity of nanovectorized TRAIL compared to its cytotoxic version by affinity chromatography and molecular docking studies.

Zakaria A, Picaud F, Guillaume YC, Gharbi T, Micheau O, Herlem G

J. Mol. Recognit.. 2016 Sep;29(9):406-14

Nanovectorization of DNA Through Cells Using Protamine Complexation.

Boukari K, Caoduro C, Kacem R, Skandrani N, Borg C, Boulahdour H, Gharbi T, Delage-Mourroux R, Hervouet E, Pudlo M, Picaud F

J. Membr. Biol.. 2016 Aug;249(4):493-501

Biomimetic solution against dewetting in a highly hydrophobic nanopore.

Picaud F, Paris G, Gharbi T, Balme S, Lepoitevin M, Tangaraj V, Bechelany M, Janot JM, Balanzat E, Henn F

Soft Matter. 2016 Jun 14;12(22):4903-11

Towards New Insights in the Sterol/Amphotericin Nanochannels Formation: A Molecular Dynamic Simulation Study.

Boukari K, Balme S, Janot JM, Picaud F

J Membr Biol. 2016 06;249(3):261-70

Theoretical demonstration of the potentiality of boron nitride nanotubes to encapsulate anticancer molecule.

El Khalifi M, Duverger E, Gharbi T, Boulahdour H, Picaud F

Phys Chem Chem Phys. 2015 Nov 28;17(44):30057-64

Ionic transport through sub-10 nm diameter hydrophobic high-aspect ratio nanopores: experiment, theory and simulation.

Balme S, Picaud F, Manghi M, Palmeri J, Bechelany M, Cabello-Aguilar S, Abou-Chaaya A, Miele P, Balanzat E, Janot JM

Sci Rep. 2015 Jun 3;5:10135

Encapsulation into carbon nanotubes and release of anticancer Cisplatin drug molecule.

Mejri A, Vardanega D, Tangour B, Gharbi T, Picaud F

J Phys Chem B. 2015 Jan 15;119(2):604-11

Nanovectorization of TRAIL with single wall carbon nanotubes enhances tumor cell killing.

Zakaria AB, Picaud F, Rattier T, Pudlo M, Saviot L, Chassagnon R, Lherminier J, Gharbi T, Micheau O, Herlem G

Nano Lett. 2015 Jan 13.

Quantum study of boron nitride nanotubes functionalized with anticancer molecules.

Duverger E, Gharbi T, Delabrousse E, Picaud F

Phys Chem Chem Phys. 2014 Sep 14;16(34):18425-32

Experimental and simulation studies of unusual current blockade induced by translocation of small oxidized PEG through a single nanopore.

Cabello-Aguilar S, Abou Chaaya A, Picaud F, Bechelany M, Pochat-Bohatier C, Yesylevskyy S, Kraszewski S, Bechelany MC, Rossignol F, Balanzat E, Janot JM, Miele P, Dejardin P, Balme S

Phys Chem Chem Phys. 2014 Sep 7;16(33):17883-92

Ionic selectivity of nystatin A1 confined in nanoporous track-etched polymer membrane.

Balme S, Thiele D, Kraszewski S, Picaud F, Janot JM, Déjardin P

IET Nanobiotechnol. 2014 Sep;8(3):138-42

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