[Non-metastatic triple-negative breast cancer in 2016: Definitions and management].
Fiche publication
Date publication
septembre 2016
Journal
Gynecologie, obstetrique & fertilite
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ARNOULD Laurent, Pr COUTANT Charles, Dr MARTIN Etienne, Dr DESMOULINS Isabelle
Tous les auteurs :
Portha H, Jankowski C, Cortet M, Desmoulins I, Martin E, Lorgis V, Arnould L, Coutant C
Lien Pubmed
Résumé
Triple-negative breast cancer (TN), as defined by the triple negativity in immunohistochemistry: the absence of estrogen receptor, progesterone receptor and the absence of overexpression or amplification of HER2, corresponds to 15 % of invasive breast cancers. This is a very heterogeneous group of tumors both at the genomic and transcriptomic level and at morphological, clinical and prognostic level. Although there are some good prognosis forms, the majority of TN tumors is characterized by a poor prognosis with a greater frequency of visceral metastases and a maximum risk of relapse in the first two years after diagnosis. Systemic adjuvant treatment with chemotherapy is almost always indicated. The surgical treatment and radiotherapy treatment should be comparable to the other subtypes and obey the same rules of oncologic surgery. TN tumors are not associated with a higher risk of locoregional relapse after conservative treatment and adjuvant radiotherapy. Optimization of systemic therapies is currently and for the last decade a challenge. A number of targeted therapies and efficiency biomarkers identification of these targeted therapies is essential to allow significant progress in optimizing systemic therapy for these tumors.
Mots clés
Adjuvant systemic therapies, Cancer du sein triple-négatif, Locoregional treatments, Prognostic, Pronostic, Traitement adjuvant, Traitement locorégional, Triple-negative breast cancer
Référence
Gynecol Obstet Fertil. 2016 Sep;44(9):492-504