Solid-phase synthesis of CD40L mimetics.
Fiche publication
Date publication
avril 2006
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FOURNEL Sylvie, Dr BIANCO Alberto
Tous les auteurs :
Bianco A, Fournel S, Wieckowski S, Hoebeke J, Guichard G
Lien Pubmed
Résumé
The C3-symmetric molecule has been previously shown to mimic CD40 ligand (CD40L) homotrimers and to display effector functions. This molecule consists of a cyclic hexapeptide core containing the repetition of the D-Ala-L-Lys motif. The side chains of the lysine residues have been modified by appending the CD40L-derived sequence 143Lys-Gly-Tyr-Tyr146 via a 6-aminohexanoic acid residue as a spacer. The present report describes a general solid-phase synthesis approach to and related trimeric architectures. In addition, their CD40 binding properties as well as their effector functions have been evaluated.
Référence
Org Biomol Chem. 2006 Apr 21;4(8):1461-3