D'Ancona C, Cruz Da Silva E, Denechere L, Justiniano H, Calco V, Richert L, Vauchelles R, Sensoy D, Dussoulliez C, Seguin C, Villa P, Daubeuf F, Kichler A, Fournel S, Anton H, Lehmann M, Choulier L

Nanoscale. 2026 07 2;:

Physiological Metal-Based Nanoparticles as Bioactive Agents for Antimicrobial Activity and Wound Repair: Strategies for hydrogel-mediated delivery.

Brice L, Ortet L, Fournel S, Maillard E, Clarot I, Vrana NE, Lavalle P, Boudier A

Acta Biomater. 2026 06 16;:

N-Heterocyclic carbene platinum complexes encapsulated in lipid particles: a novel strategy to target cancer cells and cancer stem cells in glioblastoma.

Fernandez de Larrinoa P, Kichler A, Dontenwill M, Herold-Mende C, Fournel S, Frisch B, Bellemin-Laponnaz S, Heurtault B

RSC Med Chem. 2025 06 2;:

NOD1 Agonist Induces Proliferation and Plasma Cell Differentiation of Mouse B Cells Especially CD23 B Cells.

Seguin C, Seif M, Jacoberger-Foissac C, Gentine P, Wantz M, Frisch B, Heurtault B, Fournel S

Immunol Invest. 2024 11 19;:1-15

N-terminal modification of an LAH4-derived peptide increases mRNA delivery in the presence of serum.

Dussouillez C, Lointier M, Sebane MK, Fournel S, Bechinger B, Kichler A

J Pept Sci. 2024 03 25;:e3597

Triphenylphosphonium-functionalized N-heterocyclic carbene platinum complexes [(NHC-TPP)Pt] induce cell death of human glioblastoma cancer stem cells.

Fernandez de Larrinoa P, Parmentier J, Kichler A, Achard T, Dontenwill M, Herold-Mende C, Fournel S, Frisch B, Heurtault B, Bellemin-Laponnaz S

Int J Pharm. 2023 05 25;:123071

Evaluation of the Cytotoxicity of Cationic Polymers on Glioblastoma Cancer Stem Cells.

McCartin C, Blumberger J, Dussouillez C, Fernandez de Larrinoa P, Dontenwill M, Herold-Mende C, Lavalle P, Heurtault B, Bellemin-Laponnaz S, Fournel S, Kichler A

J Funct Biomater. 2022 12 28;14(1):

Polyethylenimine, an Autophagy-Inducing Platinum-Carbene-Based Drug Carrier with Potent Toxicity towards Glioblastoma Cancer Stem Cells.

McCartin C, Dussouillez C, Bernhard C, Mathieu E, Blumberger J, Dontenwill M, Herold-Mende C, Idbaih A, Lavalle P, Bellemin-Laponnaz S, Kichler A, Fournel S

Cancers (Basel). 2022 10 15;14(20):

An N-heterocyclic carbene iridium(III) complex as a potent anti-cancer stem cell therapeutic.

McCartin C, Mathieu E, Dontenwill M, Herold-Mende C, Idbaih A, Bonfiglio A, Mauro M, Fournel S, Kichler A

Chem Biol Interact. 2022 09 7;:110167

Polyarginine as a simultaneous antimicrobial, immunomodulatory and miRNA delivery agent within polyanionic hydrogels.

Gribova V, Petit L, Seguin C, Fournel S, Kichler A, Vrana NE, Lavalle P

Macromol Biosci. 2022 Mar 25;:e2200043

Anti-inflammatory effects of free and liposome-encapsulated natural Algerian thermal water in RAW 264.7 macrophages.

Mokdad R, Seguin C, Fournel S, Frisch B, Heurtault B, Hadjsadok A

Int J Pharm. 2022 Jan 7;:121452

Past mastering of metal transformation enabled physicians to increase their therapeutic potential.

Abdallah B, Seguin C, Aubert E, Ait BenHassou H, Sbabou L, Choulier L, Vonthron C, Schalk IJ, Mislin GLA, Fournel S, Pitchon V, Fechter P

J Trace Elem Med Biol. 2022 Jan 5;71:126926

Recent Advances in Antiinflammatory Material Design.

Lebaudy E, Fournel S, Lavalle P, Vrana NE, Gribova V

Adv Healthc Mater. 2020 Oct 13;:e2001373

Liposomes as tunable platform to decipher the antitumor immune response triggered by TLR and NLR agonists.

Jacoberger-Foissac C, Saliba H, Wantz M, Seguin C, Flacher V, Frisch B, Heurtault B, Fournel S

Eur J Pharm Biopharm. 2020 May 29;:

La Société de Biologie de Strasbourg : 100 ans au service de la science et de la société

Antony P, Fournel S, Zoll J, Mantz JM, Befort K, Massotte D, Giégé P, Céraline J, Metzger D, Becker H, Drouard L, Florentz C, Martin R, Nébigil C, Potier S, Schaefer A, Schaeffer E, Schuster C, Bresson A, Quéméneur E, Choulier L, Matt N, Monassier L, Lugnier C, Freysz L, Hoffmann J, Dreyfus H, Romier C

Biol Aujourdhui. 2020 ;214(3-4):137-148

Optimization of peptide-based cancer vaccine compositions, by sequential screening, using versatile liposomal platform.

Jacoberger-Foissac C, Saliba H, Seguin C, Brion A, Kakhi Z, Frisch B, Fournel S, Heurtault B

Int J Pharm. 2019 Mar 14;:

BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo.

Schleiss C, Ilias W, Tahar O, Güler Y, Miguet L, Mayeur-Rousse C, Mauvieux L, Fornecker LM, Toussaint E, Herbrecht R, Bertrand F, Maumy-Bertrand M, Martin T, Fournel S, Georgel P, Bahram S, Vallat L

Sci Rep. 2019 Jan 24;9(1):701

-Heterocyclic Carbene-Polyethyleneimine (PEI) Platinum Complexes Inducing Human Cancer Cell Death: Polymer Carrier Impact.

Wantz M, Bouché M, Dahm G, Chekkat N, Fournel S, Bellemin-Laponnaz S

Int J Mol Sci. 2018 Nov 5;19(11):

β-Cyclodextrin-functionalized Chitosan/Alginate Compact PolyElectrolyte Complexes (CoPECs) as Functional Biomaterials with Anti-Inflammatory Properties.

Hardy A, Seguin C, Brion A, Lavalle P, Schaaf P, Fournel S, Bourel-Bonnet L, Frisch B, De Giorgi DM

ACS Appl Mater Interfaces. 2018 Aug 14;:

Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes.

Chekkat N, Lombardo CM, Seguin C, Lechner MC, Dufour F, Nominé Y, De Giorgi M, Frisch B, Micheau O, Guichard G, Altschuh D, Fournel S

Oncotarget. 2018 Mar 20;9(21):15566-15578

Physical oncology: New targets for nanomedicine.

Nicolas-Boluda A, Silva AKA, Fournel S, Gazeau F

Biomaterials. 2018 Jan;150:87-99

Enhancing tumor specific immune responses by transcutaneous vaccination.

Saliba H, Heurtault B, Bouharoun-Tayoun H, Flacher V, Frisch B, Fournel S, Chamat S

Expert Rev Vaccines. 2017 Sep;:

Solubilization of α-galactosylceramide in aqueous medium: impact on Natural Killer T cell activation and antitumor responses.

Macho-Fernandez E, Chekkat N, Ehret C, Thomann JS, De Giorgi M, Spanedda MV, Bourel-Bonnet L, Betbeder D, Heurtault B, Faveeuw C, Fournel S, Frisch B, Trottein F

Int J Pharm. 2017 Jul;:

Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling.

Smulski CR, Decossas M, Chekkat N, Beyrath J, Willen L, Guichard G, Lorenzetti R, Rizzi M, Eibel H, Schneider P, Fournel S

Cell Death Dis. 2017 Feb;8(2):e2601

Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels.

Beyrath J, Chekkat N, Smulski CR, Lombardo CM, Lechner MC, Seguin C, Decossas M, Spanedda MV, Frisch B, Guichard G, Fournel S

Oncotarget. 2016 10;7(40):64942-64956

N-Heterocyclic Carbene-Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy.

Chekkat N, Dahm G, Chardon E, Wantz M, Sitz J, Decossas M, Lambert O, Frisch B, Rubbiani R, Gasser G, Guichard G, Fournel S, Bellemin-Laponnaz S

Bioconjug. Chem.. 2016 Aug;27(8):1942-8

Platinum(iv) N-heterocyclic carbene complexes: their synthesis, characterisation and cytotoxic activity.

Bouché M, Dahm G, Wantz M, Fournel S, Achard T, Bellemin-Laponnaz S

Dalton Trans. 2016 Jul;45(28):11362-8

Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor microenvironment.

Fend L, Remy-Ziller C, Foloppe J, Kempf J, Cochin S, Barraud L, Accart N, Erbs P, Fournel S, Préville X

Oncoimmunology. 2016 Feb;5(2):e1080414

Smart tools and orthogonal click-like reactions onto small unilamellar vesicles: Additional molecular data.

Vittoria Spanedda M, Salome C, Hilbold B, Berner E, Heurtault B, Fournel S, Frisch B, Bourel-Bonnet L

Data Brief. 2015 Aug 28;5:145-54

Smart tools and orthogonal click-like reactions onto small unilamellar vesicles.

Salomé C, Spanedda MV, Hilbold B, Berner E, Heurtault B, Fournel S, Frisch B, Bourel-Bonnet L

Chem. Phys. Lipids. 2015 May;188:27-36

Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation.

Pulka-Ziach K, Pavet V, Chekkat N, Estieu-Gionnet K, Rohac R, Lechner MC, Smulski CR, Zeder-Lutz G, Altschuh D, Gronemeyer H, Fournel S, Odaert B, Guichard G

Chembiochem. 2015 Jan;16(2):293-301

Intravenous injection of MVA virus targets CD8+ lymphocytes to tumors to control tumor growth upon combinatorial treatment with a TLR9 agonist.

Fend L, Gatard-Scheikl T, Kintz J, Gantzer M, Schaedler E, Rittner K, Cochin S, Fournel S, Preville X

Cancer Immunol Res. 2014 Dec;2(12):1163-74

Biodistribution of X-ray iodinated contrast agent in nano-emulsions is controlled by the chemical nature of the oily core.

Attia MF, Anton N, Chiper M, Akasov R, Anton H, Messaddeq N, Fournel S, Klymchenko AS, Mely Y, Vandamme TF

ACS Nano. 2014 Oct 28;8(10):10537-50

Multimerization of an apoptogenic TRAIL-mimicking peptide by using adamantane-based dendrons.

Lamanna G, Smulski CR, Chekkat N, Estieu-Gionnet K, Guichard G, Fournel S, Bianco A

Chemistry. 2013 Jan 28;19(5):1762-8

Easy Derivatisation of Group 10 N-Heterocyclic Carbene Complexes and In Vitro Evaluation of an Anticancer Oestradiol Conjugate.

Chardon E, Puleo GL, Dahm G, Fournel S, Guichard G, Bellemin-Laponnaz S

. 2012 Nov;77(11):1028-38.

Activation of invariant Natural Killer T lymphocytes in response to the alpha-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nanoparticles and microparticles.

Macho Fernandez E, Chang J, Fontaine J, Bialecki E, Rodriguez F, Werkmeister E, Krieger V, Ehret C, Heurtault B, Fournel S, Frisch B, Betbeder D, Faveeuw C, Trottein F

Int J Pharm. 2012 Feb 14;423(1):45-54

Antitumor activity of liposomal ErbB2/HER2 epitope peptide-based vaccine constructs incorporating TLR agonists and mannose receptor targeting.

Thomann JS, Heurtault B, Weidner S, Braye M, Beyrath J, Fournel S, Schuber F, Frisch B

Biomaterials. 2011 Jul;32(20):4574-83

Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells.

Boeglin E, Smulski CR, Brun S, Milosevic S, Schneider P, Fournel S

PLoS One. 2011;6(10):e25542

Ligand dimerization programmed by hybridization to study multimeric ligand-receptor interactions.

Gorska K, Beyrath J, Fournel S, Guichard G, Winssinger N

Chem Commun (Camb). 2010 Nov 7;46(41):7742-4

Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.

Spanedda MV, Heurtault B, Weidner S, Baehr C, Boeglin E, Beyrath J, Milosevic S, Bourel-Bonnet L, Fournel S, Frisch B

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1869-72

Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.

Pavet V, Beyrath J, Pardin C, Morizot A, Lechner MC, Briand JP, Wendland M, Maison W, Fournel S, Micheau O, Guichard G, Gronemeyer H

Cancer Res. 2010 Feb 1;70(3):1101-10

Consequences of isostructural main-chain modifications for the design of antimicrobial foldamers: helical mimics of host-defense peptides based on a heterogeneous amide/urea backbone.

Claudon P, Violette A, Lamour K, Decossas M, Fournel S, Heurtault B, Godet J, Mely Y, Jamart-Gregoire B, Averlant-Petit MC, Briand JP, Duportail G, Monteil H, Guichard G

Angew Chem Int Ed Engl. 2010;49(2):333-6.