Primitive liver cancers: epidemiology and geographical study in France.
Fiche publication
Date publication
septembre 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BOUVIER Anne-Marie
Tous les auteurs :
Borie F, Tretarre B, Bouvier AM, Faivre J, Binder F, Launoy G, Delafosse P, Tissot J, Peng J, Grosclaude P, Guizard AV, Gras-Aygon C
Lien Pubmed
Résumé
OBJECTIVES: The objectives of this study are, first, to describe the incidence of primary liver cancer (PLC) and, second, to highlight its epidemiological characteristics from a geographical point of view. METHODS: The nine French administrative areas, which are covered by population-based cancer registries, diagnosed a total of 1100 new cases of PLC (of which 898 occurred in males), between 1997 and 1998; 91.5% of these were identified as hepatocellular carcinoma, and 6.2% corresponded to intrahepatic cholangiocarcinoma. The incidence rates of these new cases were studied as a function of their clinico-pathological features and geographical location. RESULTS: The age-adjusted incidence was 9.5 per 100,000 persons amongst males, and 3.1 per 100,000 persons amongst females. The origin of cirrhosis was found to be alcohol consumption (69%), followed by viral contamination, and lastly 4.9% for both. A north-south gradient was found for the age-standardized incidence rates in men (10.1 per 100,000 in the north vs. 6.5 per 100,000 in the south; P=0.029). Amongst men in the north, the most frequent etiological type was cirrhosis (79.8 vs. 72.5%; P=0.0018). The alcoholic origin of cirrhosis was more frequent in the north than in the south (66 vs. 27.5%; P
Référence
Eur J Gastroenterol Hepatol. 2009 Sep;21(9):984-9.