Postel S, Wissler L, Johansson CA, Gunnarsson A, Gordon E, Collins B, Castaldo M, Köhler C, Öling D, Johansson P, Fröderberg Roth L, Beinsteiner B, Dainty I, Delaney S, Klaholz BP, Billas IML, Edman K

Nat Struct Mol Biol. 2023 02 6;:

A novel nuclear receptor subfamily enlightens the origin of heterodimerization.

Beinsteiner B, Markov GV, Bourguet M, McEwen AG, Erb S, Patel AKM, El Khaloufi El Khaddar FZ, Lecroisey C, Holzer G, Essabri K, Hazemann I, Hamiche A, Cianférani S, Moras D, Laudet V, Billas IML

BMC Biol. 2022 10 5;20(1):217

A structural signature motif enlightens the origin and diversification of nuclear receptors.

Beinsteiner B, Markov GV, Erb S, Chebaro Y, McEwen AG, Cianférani S, Laudet V, Moras D, Billas IML

PLoS Genet. 2021 Apr 21;17(4):e1009492

Myod1 and GR coordinate myofiber-specific transcriptional enhancers.

Rovito D, Rerra AI, Ueberschlag-Pitiot V, Joshi S, Karasu N, Dacleu-Siewe V, Rayana KB, Ghaibour K, Parisotto M, Ferry A, Jelinsky SA, Laverny G, Klaholz BP, Sexton T, Billas IML, Duteil D, Metzger D

Nucleic Acids Res. 2021 Apr 9;:

Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP.

Browning C, McEwen AG, Mori K, Yokoi T, Moras D, Nakagawa Y, Billas IML

J Pestic Sci. 2021 Feb 20;46(1):88-100

NR3E receptors in cnidarians: A new family of steroid receptor relatives extends the possible mechanisms for ligand binding.

Khalturin K, Billas IML, Chebaro Y, Reitzel AM, Tarrant AM, Laudet V, Markov GV

J Steroid Biochem Mol Biol. 2018 11;184:11-19

ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.

Carnesecchi J, Forcet C, Zhang L, Tribollet V, Barenton B, Boudra R, Cerutti C, Billas IM, Sérandour AA, Carroll JS, Beaudoin C, Vanacker JM

Proc Natl Acad Sci U S A. 2017 04 11;114(15):3909-3914

Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen.

Markov GV, Gutierrez-Mazariegos J, Pitrat D, Billas IML, Bonneton F, Moras D, Hasserodt J, Lecointre G, Laudet V

Sci Adv. 2017 Mar;3(3):e1601778

The integrative role of cryo electron microscopy in molecular and cellular structural biology.

Orlov I, Myasnikov AG, Andronov L, Natchiar SK, Khatter H, Beinsteiner B, Ménétret JF, Hazemann I, Mohideen K, Tazibt K, Tabaroni R, Kratzat H, Djabeur N, Bruxelles T, Raivoniaina F, Pompeo LD, Torchy M, Billas I, Urzhumtsev A, Klaholz BP

Biol. Cell. 2017 Feb;109(2):81-93

Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor.

Mohideen-Abdul K, Tazibt K, Bourguet M, Hazemann I, Lebars I, Takacs M, Cianférani S, Klaholz BP, Moras D, Billas IML

Front Endocrinol (Lausanne). 2017 ;8:140

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.

Thébault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honoré J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianférani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J

Sci Rep. 2016 Jan;6:19725

Structure-function relationships in nuclear receptors: the facts.

Moras D, Billas IM, Rochel N, Klaholz BP

Trends Biochem Sci. 2015 Jun;40(6):287-90

Purification, characterization and crystallization of the human 80S ribosome.

Khatter H, Myasnikov AG, Mastio L, Billas IM, Birck C, Stella S, Klaholz BP

Nucleic Acids Res. 2014 Apr;42(6):e49

The palindromic DNA-bound USP/EcR nuclear receptor adopts an asymmetric organization with allosteric domain positioning.

Maletta M, Orlov I, Roblin P, Beck Y, Moras D, Billas IM, Klaholz BP

Nat Commun. 2014 Jun 19;5:4139

Reconstruction of quaternary structure from X-ray scattering by equilibrium mixtures of biological macromolecules.

Petoukhov MV, Billas IM, Takacs M, Graewert MA, Moras D, Svergun DI

Biochemistry. 2013 Oct 1;52(39):6844-55

Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.

Simonetti A, Marzi S, Billas IM, Tsai A, Fabbretti A, Myasnikov AG, Roblin P, Vaiana AC, Hazemann I, Eiler D, Steitz TA, Puglisi JD, Gualerzi CO, Klaholz BP

Proc. Natl. Acad. Sci. U.S.A.. 2013 Sep 24;110(39):15656-61

Allosteric controls of nuclear receptor function in the regulation of transcription.

Billas I, Moras D

J Mol Biol. 2013 Jul 10;425(13):2317-29

The asymmetric binding of PGC-1alpha to the ERRalpha and ERRgamma nuclear receptor homodimers involves a similar recognition mechanism.

Takacs M, Petoukhov MV, Atkinson RA, Roblin P, Ogi FX, Demeler B, Potier N, Chebaro Y, Dejaegere A, Svergun DI, Moras D, Billas IM

PLoS One. 2013 Jul 9;8(7):e67810

Quantitative cell-based reporter gene assays using droplet-based microfluidics.

Baret JC, Beck Y, Billas-Massobrio I, Moras D, Griffiths AD

Chem Biol. 2010 May 28;17(5):528-36.

The ligand-binding domains of the three RXR-USP nuclear receptor types support distinct tissue and ligand specific hormonal responses in transgenic Drosophila.

Beck Y, Delaporte C, Moras D, Richards G, Billas IM

Dev Biol. 2009 Jun 1;330(1):1-11

Structural and evolutionary innovation of the heterodimerization interface between USP and the ecdysone receptor ECR in insects.

Iwema T, Chaumot A, Studer RA, Robinson-Rechavi M, Billas IM, Moras D, Laudet V, Bonneton F

Mol Biol Evol. 2009 Apr;26(4):753-68

Dr BILLAS Isabelle

Fiche personne

coordonnées

Territoire

Statut

affiliation

équipes/plateformes

Projets

Etudes structurales et fonctionnelles du récepteur des glucocorticoïdes comme cible thérapeutique dans le traitement du cancer de la prostate

Publications

Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA.

Structural insights into the HNF4 biology.

Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.