Cova G, Taroni C, Deau MC, Cai Q, Mittelheisser V, Philipps M, Jung M, Cerciat M, Le Gras S, Thibault-Carpentier C, Jost B, Carlsson L, Thornton AM, Shevach EM, Kirstetter P, Kastner P, Chan S

J Exp Med. 2021 Oct 4;218(10):

Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4 T Cells.

Lancien M, Bienvenu G, Salle S, Gueno L, Feyeux M, Merieau E, Remy S, Even A, Moreau A, Molle A, Fourgeux C, Coulon F, Beriou G, Bouchet-Delbos L, Chiffoleau E, Kirstetter P, Chan S, Kerfoot SM, Abdu Rahiman S, De Simone V, Matteoli G, Boncompain G, Perez F, Josien R, Poschmann J, Cuturi MC, Louvet C

J Immunol. 2021 Jul 7;:

Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development.

Mastio J, Simand C, Cova G, Kastner P, Chan S, Kirstetter P

PLoS Genet.. 2018 Jul;14(7):e1007485

Severe combined immunodeficiency in Sting V154M/WT mice.

Bouis D, Kirstetter P, Arbogast F, Lamon D, Delgado V, Jung S, Ebel C, Jacobs H, Knapp AM, Jeremiah N, Belot A, Martin T, Crow YJ, André-Schmutz I, Korganow AS, Rieux-Laucat F, Soulas-Sprauel P

J. Allergy Clin. Immunol.. 2018 May 23;:

Treatment of MCPT8 mice with high- or low-dose diphtheria toxin leads to differential depletion of basophils and granulocyte-macrophage progenitors.

El Hachem C, Hener P, Kirstetter P, Li J, Chan S, Li M

Eur. J. Immunol.. 2018 Jan 8;:

Dr KIRSTETTER Peggy

Fiche personne

coordonnées

Territoire

Statut

affiliation

équipes/plateformes

Projets

Rôles d'Ikaros et Helios dans le maintien des cellules souches hématopoïétiques normales et leucémiques

Effet d’un inhibiteur de la -secretase sur l’expansion des progéniteurs hématopoïétiques de sang de cordon

Publications

CD4 regulatory T cells lacking Helios and Eos.

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.

Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4 T Cells.

Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development.

Severe combined immunodeficiency in Sting V154M/WT mice.

Treatment of MCPT8 mice with high- or low-dose diphtheria toxin leads to differential depletion of basophils and granulocyte-macrophage progenitors.

Therapeutical modulation of plasmacytoid dendritic cells in experimental arthritis.

Sumoylation Inhibits the Growth Suppressive Properties of Ikaros.

beta-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL.

Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice.