Baka Z, Godier C, Lamy L, Mallick A, Gribova V, Figarol A, Bezdetnaya L, Chateau A, Magne Z, Stiefel M, Louaguef D, Lavalle P, Gaffet E, Joubert O, Alem H

Macromol Biosci. 2022 11 29;:e2200434

Quantum Dots Mediated Imaging and Phototherapy in Cancer Spheroid Models: State of the Art and Perspectives.

Dirheimer L, Pons T, Marchal F, Bezdetnaya L

Pharmaceutics. 2022 10 8;14(10):

Antitumor Effect and Induced Immune Response Following Exposure of Hexaminolevulinate and Blue Light in Combination with Checkpoint Inhibitor in an Orthotopic Model of Rat Bladder Cancer.

Lamy L, Thomas J, Leroux A, Bisson JF, Myren K, Godal A, Stensrud G, Bezdetnaya L

Biomedicines. 2022 Feb 25;10(3):

Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency.

Siblini Y, Chéry C, Rouyer P, Raso J, Julien A, Hergalant S, François A, Bezdetnaya L, Vogin G, Guéant JL, Oussalah A

Clin Epigenetics. 2021 Dec 1;13(1):212

Analysis of Fluorescence Decay Kinetics of Indocyanine Green Monomers and Aggregates in Brain Tumor Model In Vivo.

Farrakhova D, Romanishkin I, Maklygina Y, Bezdetnaya L, Loschenov V

Nanomaterials (Basel). 2021 Nov 24;11(12):

FLUORESCENCE IMAGING ANALYSIS OF DISTRIBUTION OF INDOCYANINE GREEN IN MOLECULAR AND NANOFORM IN TUMOR MODEL.

Farrakhova D, Maklygina Y, Romanishkin I, Yakovlev D, Plyutinskaya A, Bezdetnaya L, Loschenov V

Photodiagnosis Photodyn Ther. 2021 Nov 19;:102636

Modulation of Temoporfin Distribution in Blood by β-Cyclodextrin Nanoshuttles.

Yakavets I, Yankovsky I, Zorina T, Belevtsev M, Bezdetnaya L, Zorin V

Pharmaceutics. 2021 Jul 9;13(7):

Validation of a Three-Dimensional Head and Neck Spheroid Model to Evaluate Cameras for NIR Fluorescence-Guided Cancer Surgery.

Egloff-Juras C, Yakavets I, Scherrer V, Francois A, Bezdetnaya L, Lassalle HP, Dolivet G

Int J Mol Sci. 2021 Feb 17;22(4):

Effect of stroma on the behavior of temoporfin-loaded lipid nanovesicles inside the stroma-rich head and neck carcinoma spheroids.

Yakavets I, Francois A, Lamy L, Piffoux M, Gazeau F, Wilhelm C, Zorin V, Silva AKA, Bezdetnaya L

J Nanobiotechnology. 2021 Jan 6;19(1):3

NIR Imaging of the Integrin-Rich Head and Neck Squamous Cell Carcinoma Using Ternary Copper Indium Selenide/Zinc Sulfide-Based Quantum Dots.

Yakavets I, Francois A, Guiot M, Lequeux N, Fragola A, Pons T, Bezdetnaya L, Marchal F

Cancers (Basel). 2020 Dec 11;12(12):

Advanced co-culture 3D breast cancer model for investigation of fibrosis induced by external stimuli: optimization study.

Yakavets I, Francois A, Benoit A, Merlin JL, Bezdetnaya L, Vogin G

Sci Rep. 2020 Dec 4;10(1):21273

mTHPC-Loaded Extracellular Vesicles Significantly Improve mTHPC Diffusion and Photodynamic Activity in Preclinical Models.

Millard M, Posty S, Piffoux M, Jasniewski J, Lassalle HP, Yakavets I, Gazeau F, Wilhelm C, Silva AKA, Bezdetnaya L

Pharmaceutics. 2020 Jul 17;12(7):

Cyclodextrin nanosponge as a Temoporfin nanocarrier: balancing between accumulation and penetration in 3D tumor spheroids.

Yakavets I, Guereschi C, Lamy L, Kravchenko I, Lassalle HP, Zorin V, Bezdetnaya L

Eur J Pharm Biopharm. 2020 Jul 4;:

ICG-induced NIR fluorescence mapping in patients with head & neck tumors after the previous radiotherapy.

Cortese S, Kerrien E, Yakavets I, Meilender R, Mastronicola R, Renard S, Leroux A, Bezdetnaya L, Dolivet G

Photodiagnosis Photodyn Ther. 2020 May 29;:101838

Trials of a Fluorescent Endoscopic Video System for Diagnosis and Treatment of the Head and Neck Cancer.

Farrakhova D, Shiryaev A, Yakovlev D, Efendiev K, Maklygina Y, Borodkin A, Loschenov M, Bezdetnaya L, Ryabova A, Amirkhanova L, Samoylova S, Rusakov M, Zavodnov V, Levkin V, Reshetov I, Loschenov V

J Clin Med. 2019 Dec 17;8(12):

Stroma-Rich Co-Culture Multicellular Tumor Spheroids as a Tool for Photoactive Drugs Screening.

Yakavets I, Jenard S, Francois A, Maklygina Y, Loschenov V, Lassalle HP, Dolivet G, Bezdetnaya L

J Clin Med. 2019 Oct 15;8(10):

Matryoshka-Type Liposomes Offer the Improved Delivery of Temoporfin to Tumor Spheroids.

Yakavets I, Millard M, Lamy L, Francois A, Scheglmann D, Wiehe A, Lassalle HP, Zorin V, Bezdetnaya L

Cancers (Basel). 2019 Sep 13;11(9):

Doxorubicin Loaded Thermo-responsive Superparamagnetic Nanocarriers for Controlled Drug Delivery and Magnetic Hyperthermia Applications.

Ferjaoui Z, Jamal Al Dine E, Jandayeva A, Bezdetnaya L, Soon Chang C, Schneider R, Mutelet F, Mertz D, Begin-Colin S, Quilès F, Gaffet E, Alem H

ACS Appl Mater Interfaces. 2019 Jul 30;:

Current state of the nanoscale delivery systems for temoporfin-based photodynamic therapy: Advanced delivery strategies.

Yakavets I, Millard M, Zorin V, Lassalle HP, Bezdetnaya L

J Control Release. 2019 May 25;:

THE TARGETING ABILITY OF FLUORESCENT QUANTUM DOTS TO THE FOLATE RECEPTOR RICH TUMORS.

Mangeolle T, Yakavets I, Lequeux N, Pons T, Bezdetnaya L, Marchal F

Photodiagnosis Photodyn Ther. 2019 Mar 15;:

NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green.

Egloff-Juras C, Bezdetnaya L, Dolivet G, Lassalle HP

Int J Nanomedicine. 2019 ;14:7823-7838

mTHPC-loaded extracellular vesicles outperform liposomal and free mTHPC formulations by an increased stability, drug delivery efficiency and cytotoxic effect in tridimensional model of tumors.

Millard M, Yakavets I, Piffoux M, Brun A, Gazeau F, Guigner JM, Jasniewski J, Lassalle HP, Wilhelm C, Bezdetnaya L

Drug Deliv. 2018 Nov;25(1):1790-1801

Temoporfin-in-Cyclodextrin-in-Liposome-A New Approach for Anticancer Drug Delivery: The Optimization of Composition.

Yakavets I, Lassalle HP, Scheglmann D, Wiehe A, Zorin V, Bezdetnaya L

Nanomaterials (Basel). 2018 Oct 18;8(10):

Photodynamic diagnosis with methyl-5-aminolevulinate in squamous intraepithelial lesions of the vulva: Experimental research.

Leufflen L, Francois A, Salleron J, Barlier C, Dolivet G, Marchal F, Bezdetnaya L

PLoS ONE. 2018 ;13(5):e0196753

The alteration of temoporfin distribution in multicellular tumor spheroids by β-cyclodextrins.

Yakavets I, Yankovsky I, Millard M, Lamy L, Lassalle HP, Wiehe A, Zorin V, Bezdetnaya L

Int J Pharm. 2017 Aug 30;529(1-2):568-575

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening.

Millard M, Yakavets I, Zorin V, Kulmukhamedova A, Marchal S, Bezdetnaya L

Int J Nanomedicine. 2017 ;12:7993-8007

Inclusion complexation with β-cyclodextrin derivatives alters photodynamic activity and biodistribution of meta-tetra(hydroxyphenyl)chlorin.

Yankovsky I, Bastien E, Yakavets I, Khludeyev I, Lassalle HP, Gräfe S, Bezdetnaya L, Zorin V

Eur J Pharm Sci. 2016 Aug 25;91:172-82

Prospects of in vivo singlet oxygen luminescence monitoring: Kinetics at different locations on living mice.

Pfitzner M, Schlothauer JC, Bastien E, Hackbarth S, Bezdetnaya L, Lassalle HP, Röder B

Photodiagnosis Photodyn Ther. 2016 Jun;14:204-10

PAMAM G4.5-chlorin e6 dendrimeric nanoparticles for enhanced photodynamic effects.

Bastien E, Schneider R, Hackbarth S, Dumas D, Jasniewski J, Roder B, Bezdetnaya L, Lassalle HP

Photochem Photobiol Sci. 2015 Oct 26.

Anticancer Drug Delivery: An Update on Clinically Applied Nanotherapeutics.

Marchal S, Hor AE, Millard M, Gillon V, Bezdetnaya L

Drugs. 2015 Sep 1.

Photodynamic therapy relieves colitis and prevents colitis-associated carcinogenesis in mice.

Reinhard A, Bressenot A, Dassonneville R, Loywick A, Hot D, Audebert C, Marchal S, Guillemin F, Chamaillard M, Peyrin-Biroulet L, Bezdetnaya L

Inflamm. Bowel Dis.. 2015 May;21(5):985-95

Detection of disseminated tumor cells in aspirative drains after neck dissection.

Mastronicola R, Berteau C, Tu Q, Cortese S, Guillet J, Phulpin B, Gangloff P, Bezdetnaya L, Merlin JL, Faure G, Dolivet G

Eur Arch Otorhinolaryngol. 2015 Jan 30.

Targeted photodynamic therapy in head and neck squamous cell carcinoma: heading into the future.

Marchal S, Dolivet G, Lassalle H, Guillemin F, Bezdetnaya L

Lasers Med Sci. 2015 Jan 7.

Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application.

Sitbon G, Bouccara S, Tasso M, Francois A, Bezdetnaya L, Marchal F, Beaumont M, Pons T

Nanoscale. 2014 Jul 1.

Factors affecting the selectivity of nanoparticle-based photoinduced damage in free and xenografted chorioallantoic membrane model.

Garrier J, Reshetov V, Grafe S, Guillemin F, Zorin V, Bezdetnaya L

J Drug Target. 2013 Nov 29.

Surface chemistry architecture of silica nanoparticles determine the efficiency of in vivo fluorescence lymph node mapping.

Helle M, Rampazzo E, Monchanin M, Marchal F, Guillemin F, Bonacchi S, Salis F, Prodi L, Bezdetnaya L

ACS Nano. 2013 Oct 22;7(10):8645-57

Treatment of vulvar intraepithelial neoplasia with CO(2) laser vaporization and excision surgery.

Leufflen L, Baermann P, Rauch P, Routiot T, Bezdetnava L, Guillemin F, Desandes E, Marchal F

J Low Genit Tract Dis. 2013 Oct;17(4):446-51

How to avoid local side effects of bladder photodynamic therapy: impact of the fluence rate.

Francois A, Salvadori A, Bressenot A, Bezdetnaya L, Guillemin F, D'Hallewin MA

J Urol. 2013 Aug;190(2):731-6

Design of new quantum dot materials for deep tissue infrared imaging.

Cassette E, Helle M, Bezdetnaya L, Marchal F, Dubertret B, Pons T

Adv Drug Deliv Rev. 2013 May;65(5):719-31

Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin): comparison of treatment efficacy and distribution characteristics in vivo.

Reshetov V, Lassalle HP, Francois A, Dumas D, Hupont S, Grafe S, Filipe V, Jiskoot W, Guillemin F, Zorin V, Bezdetnaya L

Int J Nanomedicine. 2013;8:3817-31

Fluorescence diagnosis of bladder cancer: a novel in vivo approach using 5-aminolevulinic acid (ALA) dendrimers.

Francois A, Battah S, MacRobert AJ, Bezdetnaya L, Guillemin F, D'Hallewin MA

BJU Int. 2012 Dec;110(11 Pt C):E1155-62

Aptamers as remarkable diagnostic and therapeutic agents in cancer treatment.

Lassalle HP, Marchal S, Guillemin F, Reinhard A, Bezdetnaya L

Curr Drug Metab. 2012 Oct;13(8):1130-44.

Animal Models for Photodiagnosis and Photodynamic Therapy.

D'Hallewin M, Helle M, Garrier J, Bezdetnaya L, Guillemin F

. 2012 Sep;52(8-9):706-14.

Interaction of liposomal formulations of meta-tetra(hydroxyphenyl)chlorin (temoporfin) with serum proteins: protein binding and liposome destruction.

Reshetov V, Zorin V, Siupa A, D'Hallewin MA, Guillemin F, Bezdetnaya L

Photochem Photobiol. 2012 Sep-Oct;88(5):1256-64

Visualisation of sentinel lymph node with indium-based near infrared emitting Quantum Dots in a murine metastatic breast cancer model.

Helle M, Cassette E, Bezdetnaya L, Pons T, Leroux A, Plenat F, Guillemin F, Dubertret B, Marchal F

PLoS One. 2012;7(8):e44433

Foslip(R)-based photodynamic therapy as a means to improve wound healing.

Garrier J, Bezdetnaya L, Barlier C, Grafe S, Guillemin F, D'Hallewin MA

Photodiagnosis Photodyn Ther. 2011 Dec;8(4):321-7

mTHPC-based photodynamic therapy induction of autophagy and apoptosis in cultured cells in relation to mitochondria and endoplasmic reticulum stress.

Francois A, Marchal S, Guillemin F, Bezdetnaya L

Int J Oncol. 2011 Dec;39(6):1537-43

Evaluation of combined matrix-assisted laser desorption/ionization time-of-flight and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry experiments for peptide mass fingerprinting analysis.

da Silva D, Wasselin T, Carre V, Chaimbault P, Bezdetnaya L, Maunit B, Muller JF

Rapid Commun Mass Spectrom. 2011 Jul 15;25(13):1881-92

Redistribution of meta-tetra(hydroxyphenyl)chlorin (m-THPC) from conventional and PEGylated liposomes to biological substrates.

Reshetov V, Kachatkou D, Shmigol T, Zorin V, D'Hallewin MA, Guillemin F, Bezdetnaya L

Photochem Photobiol Sci. 2011 Jun;10(6):911-9

Polyelectrolyte microcapsules with entrapped multicellular tumor spheroids as a novel tool to study the effects of photodynamic therapy.

Zaytseva-Zotova DS, Udartseva OO, Andreeva ER, Bartkowiak A, Bezdetnaya LN, Guillemin F, Goergen JL, Markvicheva EA

J Biomed Mater Res B Appl Biomater. 2011 May;97(2):255-62

Synthesis and Characterization of Near-Infrared Cu-In-Se/ZnS Core/Shell Quantum Dots for In vivo Imaging.

Cassette E, Pons T, Bouet C, Helle M, Bezdetnaya L, Marchal F, Dubertret B

Chem Mat. 2010 Nov 23;22(22):6117-24.

Compartmental targeting for mTHPC-based photodynamic treatment in vivo: Correlation of efficiency, pharmacokinetics, and regional distribution of apoptosis.

Garrier J, Bressenot A, Grafe S, Marchal S, Mitra S, Foster TH, Guillemin F, Bezdetnaya L

Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):563-71

Salvage photodynamic therapy for extended carcinoma in situ of the oesophagus after subtotal oesophagectomy: 2 years follow up.

D'Hallewin MA, Hudziak H, Bezdetnaya L, Didelon J, Guillemin F

Photodiagnosis Photodyn Ther. 2010 Sep;7(3):176-8

Fluorescence imaging and whole-body biodistribution of near-infrared-emitting quantum dots after subcutaneous injection for regional lymph node mapping in mice.

Pic E, Pons T, Bezdetnaya L, Leroux A, Guillemin F, Dubertret B, Marchal F

Mol Imaging Biol. 2010 Aug;12(4):394-405

Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity.

Pons T, Pic E, Lequeux N, Cassette E, Bezdetnaya L, Guillemin F, Marchal F, Dubertret B

ACS Nano. 2010 May 25;4(5):2531-8.

Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma.

Bressenot A, Marchal S, Bezdetnaya L, Garrier J, Guillemin F, Plenat F

J Histochem Cytochem. 2009 Apr;57(4):289-300

Correlation between in vivo pharmacokinetics, intratumoral distribution and photodynamic efficiency of liposomal mTHPC.

Lassalle HP, Dumas D, Grafe S, D'Hallewin MA, Guillemin F, Bezdetnaya L

J Control Release. 2009 Mar 4;134(2):118-24

Preventing bladder tumor implantation with photodynamic therapy in a rat model mimicking post-fluorescence guided transurethral resection.

Berrahmoune S, Bezdetnaya L, Leroux A, Guillemin F, D'Hallewin MA

J Urol. 2009 Mar;181(3):1381-6

Quantification Techniques and Biodistribution of Semiconductor Quantum Dots

Pic E, Bezdetnaya L, Guillemin F, Marchal F

Anticancer Agents Med Chem. 2009 Mar;9(3):295-303.

[Quantum dots in oncological surgery: the future for surgical margin status]

Marchal F, Pic E, Pons T, Dubertret B, Bolotine L, Guillemin F

Bull Cancer. 2008 Dec;95(12):1149-53.

Photodynamic therapy with intratumoral administration of Lipid-Based mTHPC in a model of breast cancer recurrence.

D'Hallewin MA, Kochetkov D, Viry-Babel Y, Leroux A, Werkmeister E, Dumas D, Grafe S, Zorin V, Guillemin F, Bezdetnaya L

Lasers Surg Med. 2008 Oct;40(8):543-9.

Analysis of differential PDT effect in rat bladder tumor models according to concentrations of intravesical hexyl-aminolevulinate.

Berrahmoune S, Fotinos N, Bezdetnaya L, Lange N, Guedenet JC, Guillemin F, D'Hallewin MA

Photochem Photobiol Sci. 2008 Sep;7(9):1018-24

Fluorescence imaging of Foscan and Foslip in the plasma membrane and in whole cells.

Lassalle HP, Wagner M, Bezdetnaya L, Guillemin F, Schneckenburger H

J Photochem Photobiol B. 2008 Jul 24;92(1):47-53

Quantum dots in axillary lymph node mapping: biodistribution study in healthy mice.

Robe A, Pic E, Lassalle HP, Bezdetnaya L, Guillemin F, Marchal F

BMC Cancer. 2008 Apr 22;8:111.

Orthotopic animal models for oncologic photodynamic therapy and photodiagnosis.

D'Hallewin MA, Berrahmoune S, Bezdetnaya L, Lassalle HP, Guillemin F

Photodiagnosis Photodyn Ther. 2007 Dec;4(4):230-6

Influence of incubation time and sensitizer localization on meta-tetra(hydroxyphenyl)chlorin (mTHPC)-induced photoinactivation of cells.

Sasnouski S, Pic E, Dumas D, Zorin V, D'Hallewin MA, Guillemin F, Bezdetnaya L

Radiat. Res.. 2007 Aug;168(2):209-17

MALDI-TOF mass spectrometric analysis for the characterization of the 5,10,15,20-tetrakis- (m-hydroxyphenyl)bacteriochlorin (m-THPBC) photoproducts in biological environment.

Lassalle HP, Lourette N, Maunit B, Muller JF, Guillemin F, Bezdetnaya-Bolotine L

J Mass Spectrom. 2005 Sep;40(9):1149-56.

Temporally and spatially heterogeneous distribution of mTHPC in a murine tumor observed by two-color confocal fluorescence imaging and spectroscopy in a whole-mount model.

Mitra S, Maugain E, Bolotine L, Guillemin F, Foster TH

Photochem Photobiol. 2005 Sep-Oct;81(5):1123-30.

Effect of irradiation fluence rate on the efficacy of photodynamic therapy and tumor oxygenation in meta-tetra (hydroxyphenyl) chlorin (mTHPC)-sensitized HT29 xenografts in nude mice.

Coutier S, Bezdetnaya LN, Foster TH, Parache RM, Guillemin F

Radiat. Res.. 2002 Sep;158(3):339-45

Encapsulated cancer cells as a model to study the effect of antitumor therapy on small size tumors.

Markvicheva E, Jourdain C, Barth

International Congress on advances in the use of multicellular spheroids in cancer biology and therapy, Roma, 2002

Characterization by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry of the major photoproducts of temoporfin (m-THPC) and bacteriochlorin (m-THPBC).

Angotti M, Maunit B, Muller JF, Bezdetnaya L, Guillemin F

J Mass Spectrom. 2001 Jul;36(7):825-31

Effects of fluence rate on cell survival and photobleaching in meta-tetra-(hydroxyphenyl)chlorin-photosensitized Colo 26 multicell tumor spheroids.

Coutier S, Mitra S, Bezdetnaya LN, Parache RM, Georgakoudi I, Foster TH, Guillemin F

Photochem. Photobiol.. 2001 Mar;73(3):297-303

Biosynthesis and photodynamic efficacy of protoporphyrin IX (PpIX) generated by 5-aminolevulinic acid (ALA) or its hexylester (hALA) in rat bladder carcinoma cells.

Cosserat-Gerardin I, Bezdetnaya L, Notter D, Vigneron C, Guillemin F

J. Photochem. Photobiol. B, Biol.. 2000 Dec;59(1-3):72-9

Enhancement of meta-tetrahydroxyphenylchlorin-sensitized photodynamic treatment on human tumor xenografts using a water-soluble vitamin E analogue, Trolox.

Melnikova VO, Bezdetnaya LN, Brault D, Potapenko AY, Guillemin F

Int. J. Cancer. 2000 Dec;88(5):798-803

Photodynamic properties of meta-tetra(hydroxyphenyl)chlorin in human tumor cells.

Melnikova VO, Bezdetnaya LN, Potapenko AY, Guillemin F

Radiat. Res.. 1999 Oct;152(4):428-35

Laser desorption/ionization coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry : A method to characterize Temoporfin photoproducts.

Angotti M, Maunit B, Muller JF, Bezdetnaya L, Guillemin F

Rapid Communications in Mass Spectrometry (RCM), Janvier 1999, 13, 597-603.

[In vitro comparison of the photodynamic activity of meso-tetra (m-hydroxyphenyl) chlorin and hematoporphyrin derivative].

Rezzoug H, Barberi-Heyob M, Merlin JL, Bolotine L, Lignon D, Guillemin F

Bull Cancer. 1996 Oct;83(10):816-22