Fiche publication
Date publication
juillet 2026
Journal
STAR protocols
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann
Tous les auteurs :
Raza MA, Folz A, Victorino DB, Xing Z, Chen XQ, Zuo X, Borden LK, Potier MC, Mobley W, Dierssen M, Hiratsuka M, Kazuki Y, Welshhans K, Maugham-Macan M, Tramutola A, Okun E, Reeves R, Roper RJ, Yu YE, Hérault Y, Tybulewicz VLJ, Fisher EMC, Sathyanesan A
Lien Pubmed
Résumé
Rodent models of Down syndrome (DS) have been transformative in identifying basic mechanisms underlying the effects of Trisomy 21 at the molecular, cellular, physiological, and neurobehavioral levels. Each model, with its unique genomic architecture, has advanced our understanding of the complex multisystem etiology of DS. The availability of multiple models necessitates the challenge of selecting appropriate models to address a particular scientific question, experimental design, and translational relevance. This primer guides the reader through the various rodent models of DS and the genomic and phenotypic effects they recapitulate. We also provide recommendations and strategies for using DS rodent models to enable effective and robust forward and reverse translational approaches.
Mots clés
Behavior, Developmental biology, NMGN Focused Collection, Neuroscience
Référence
STAR Protoc. 2026 07 24;7(3):104717
