Fiche publication
Date publication
avril 2026
Journal
Frontiers in immunology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CADIOT Guillaume
Tous les auteurs :
Boumela N, Cadiot G, Chaoui F
Lien Pubmed
Résumé
Pernicious anemia (PA) is a severe clinical consequence of autoimmune gastritis. It results from immune-mediated damage to gastric parietal cells in the oxyntic mucosa. This process leads to intrinsic factor deficiency and subsequent vitamin B malabsorption. This complex autoimmune response, combined with non-specific clinical manifestations, generates substantial diagnostic uncertainty. This uncertainty frequently results in misdiagnosis or delayed diagnosis and, consequently, multiple adverse outcomes, including irreversible neurological complications.
Mots clés
AI-assisted diagnosis, B12 deficiency, OLGA classification, fundic atrophy, pernicious anemia
Référence
Front Immunol. 2026 04 28;17:1700751
