Fiche publication
Date publication
mai 2026
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann
,
Mme MESSADDEQ Nadia
Tous les auteurs :
Baniowska MR, Mumford P, Prestia F, Stephan P, Beament M, Birling MC, Lanzillotta C, Ciafardini L, Barone E, Lau G, Chevalier C, Nahy C, Messaddeq N, Lestra T, Wu Y, Nalesso V, Di Domenico F, Wiseman F, Herault Y
Lien Pubmed
Résumé
Down syndrome (DS) is the leading genetic cause of intellectual disability and Alzheimer's disease (AD), with over 90% of individuals developing AD-related dementia (DSAD). The triplication of the APP gene on chromosome 21 drives early amyloid-β (Aβ) accumulation, but other Hsa21 genes also contribute to pathology. Current DSAD models are limited by species-specific Aβ differences.
Mots clés
Down syndrome, ageing, anxiety, brain metabolism, cognition, learning and memory, mouse model, neurodegeneration
Référence
Alzheimers Dement. 2026 05;22(5):e71498
